10 datasets found
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Federal
Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease
U.S. Department of Health & Human Services —
Acute chest syndrome (ACS) of sickle cell disease (SCD) is characterized pathologically by vaso-occlusive processes that result from abnormal interactions between... -
Federal
Nitric oxide: a pro-inflammatory mediator in lung disease?
U.S. Department of Health & Human Services —
Inflammatory diseases of the respiratory tract are commonly associated with elevated production of nitric oxide (NO•) and increased indices of NO• -dependent... -
Federal
Non-enzymatic glycosylation of a type I collagen matrix: effects on osteoblastic development and oxidative stress
U.S. Department of Health & Human Services —
Background The tissue accumulation of protein-bound advanced glycation endproducts (AGE) may be involved in the etiology of diabetic chronic complications, including... -
Federal
Phorbol ester induces elevated oxidative activity and alkalization in a subset of lysosomes
U.S. Department of Health & Human Services —
Background Lysosomes are acidic organelles that play multiple roles in various cellular oxidative activities such as the oxidative burst during cytotoxic killing. It... -
Federal
Peroxynitrite decomposition catalyst prevents apoptotic cell death in a human astrocytoma cell line incubated with supernatants of HIV-infected macrophages
U.S. Department of Health & Human Services —
Background Oxidative stress has shown to contribute in the mechanisms underlying apoptotic cell death occuring in AIDS-dementia complex. Here we investigated the role... -
Federal
Desferrioxamine decreases NAD redox potential of intact red blood cells: evidence for desferrioxamine as an inducer of oxidant stress in red blood cells
U.S. Department of Health & Human Services —
Background Desferrioxamine (DFO) is an important iron chelating agent. It has also been thought of as an agent with anti-oxidant potential as it chelates ferric iron... -
Federal
Chronic garlic administration protects rat heart against oxidative stress induced by ischemic reperfusion injury
U.S. Department of Health & Human Services —
Background Oxidative stress plays a major role in the biochemical and pathological changes associated with myocardial ischemic-reperfusion injury (IRI). The need to... -
Federal
Acquisition of tolerance against oxidative damage in
U.S. Department of Health & Human Services —
Background Living cells constantly sense and adapt to redox shifts by the induction of genes whose products act to maintain the cellular redox environment. In the... -
Federal
Dietary antioxidants protect gut epithelial cells from oxidant-induced apoptosis
U.S. Department of Health & Human Services —
Background The potential of ascorbic acid and two botanical decoctions, green tea and cat's claw, to limit cell death in response to oxidants were evaluated in vitro.... -
Federal
Polymorphisms in the
U.S. Department of Health & Human Services —
Background Oxidative stress, resulting in a marked increase in the level of oxygen free radicals (OFR), has been implicated in the etiology of diabetic neuropathy...
10 datasets found