Raw Data File 2022-4, Geochemical data from samples collected in 2021 for the Taylor Mountain project, Tanacross and Eagle quadrangles, Alaska, presents whole-rock trace-element and major- and minor-oxide geochemistry for samples collected to support geologic mapping and mineral exploration. During the 2021 field season, geologists from the Alaska Division of Geological & Geophysical Surveys (DGGS) conducted 1:100,000-scale bedrock geologic mapping of ~2,600 mi2 (~6,900 km2) within the Tanacross and Eagle quadrangles. The field area for the Taylor Mountain project is within a 50-mile radius of Chicken, Alaska. The project area is of current and historic interest for potential mineral resource development, including quartz vein gold (Au) mineralization, placer Au deposits, granite-hosted tin (Sn) mineralization, and intrusion-related copper (Cu)-Au deposits. Prospects in the area include Tweeden, Lilliwig Creek lode, and others. Much of the field area was mapped at 1:250,000 scale by the U.S. Geological Survey (USGS) in the 1960s (Foster, 1970, 1976). This project aims to produce more detailed and modern geologic maps and supporting datasets that will promote mineral resource exploration in eastern interior Alaska. Highlights of this DGGS eastern Taylor Mountain geochemical report include locating and sampling of the Tweeden, Lilliwig Creek lode, Moose Creek, and Fish prospects. Four samples collected at Tweeden returned gold (Au) values over 1 ppm: 21ET247-2.66 ppm Au; 21ET248-1.75 ppm Au; 21ET249-1.34 ppm Au; and 21ET250-1.3 ppm Au. A greenstone sample collected at Kechumstuk Mountain (21MLB195) returned a Cu concentration of 2,960 ppm. The DGGS map area includes a section of pre-Mississippian to Permian metasedimentary and metaigneous rocks as well as Triassic to Paleogene intrusive and volcanic rocks. Major- and trace-element geochemistry was analyzed for metamorphic rocks to distinguish between igneous and sedimentary protoliths, and for igneous rocks to characterize and differentiate Mesozoic and Cenozoic magmatic events in the area. The analytical data tables associated with this report are available through the Alaska Geochemistry database (https://maps.dggs.alaska.gov/geochem). For a direct link to this data release, see http://doi.org/10.14509/30843.