Long-term mean annual water temperature (degrees Celsius) was estimated for the E2RF1 stream network (Brakebill and Terziotti, 2011) located within the Pacific Northwest region of the United States (HUC2 = 17; the Columbia River basin, the Puget Sound watershed, the coastal drainages of Washington and Oregon, and the closed basins in southern Oregon). Multiple linear regressions were used to select reach-scale watershed attributes (explanatory variables) for predicting the long-term mean annual water temperature (dependent variable) at a set of USGS water-quality monitoring stations. The results from the multiple linear regressions were used to predict the long-term mean water temperature for the Pacific Northwest reaches in the E2RF1 network.