This dataset provides timeseries data on water quality and quantity, as collected or computed from outside sources. The format is many tables with one row per time series observation (1 tab-delimited file per site-variable combination, 1 zip file per site). This compilation of data is intended for use in estimating or interpreting metabolism. Sites were included if they met the initial criteria of having at least 100 dissolved oxygen observations and one of the accepted NWIS site types ('ST','ST-CA','ST-DCH','ST-TS', or 'SP'). This dataset is part of a larger data release of metabolism model inputs and outputs for 356 streams and rivers across the United States (https://doi.org/10.5066/F70864KX). The complete release includes: modeled estimates of gross primary productivity, ecosystem respiration, and the gas exchange coefficient; model input data and alternative input data; model fit and diagnostic information; site catchment boundaries and site point locations; and potential predictors of metabolism such as discharge and light availability.