In support of paleoclimatology investigations, samples of mammillary calcite, calcitic folia, and flowstone were collected by the U.S. Geological Survey in Devils Hole and Devils Hole Cave 2, Nevada, between 1983 and 1996. These samples came from about 60 m below to 9 m above the modern water table in these caverns. To determine δ18O and δ13C time series spanning the interval 567.7–4.5 ka, more than a thousand samples were milled and analyzed for their δ18O and δ13C values. To determine time-series ages, more than a hundred samples were analyzed using uranium-series dating. Many of these measurement results have not been published. Herein, we provide previously unpublished δ13C and δ18O values, and we provide unpublished background data for selected uranium-series ages.