We present a set of novel algorithms which we call sequenceMiner that detect and characterize anomalies in large sets of high-dimensional symbol sequences that arise from recordings of switch sensors in the cockpits of commercial airliners. While the algorithms we present are general and ___domain-independent, we focus on a specific problem that is critical to determining the system-wide health of a fleet of aircraft. The approach taken uses unsupervised clustering of sequences using the normalized length of the longest common subsequence (nLCS) as a similarity measure, followed by detailed outlier analysis to detect anomalies. In this method, an outlier sequence is defined as a sequence that is far away from the cluster centre. We present new algorithms for outlier analysis that provide comprehensible indicators as to why a particular sequence is deemed to be an outlier. The algorithms provide a coherent description to an analyst of the anomalies in the sequence when compared to more normal sequences. In the final section of the paper we demonstrate the effectiveness of sequenceMiner for anomaly detection on a real set of discrete sequence data from a fleet of commercial airliners. We show that sequenceMiner discovers actionable and operationally significant safety events. We also compare our innovations with standard HiddenMarkov Models, and show that our methods are superior.