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SO2 and PTB in NC Birth Cohort

Metadata Updated: February 17, 2025

We assembled a retrospective, administrative cohort of singleton births in North Carolina from 2003-2015. We used US EPA EQUATES data to assign long-term SO2 gestational exposures to eligible births for the entire pregnancy and by trimester. We used multivariable generalized linear regression to estimate risk differences (RD (95%CI)) per 1-ppb increase in SO2, adjusted for gestational parent education, Medicaid status, marital status, and season of conception. Multi-pollutant models were additionally adjusted for other criteria air co-pollutants (O3, PM2.5, NO2). This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: The North Carolina Birth Cohort data are not publicly available as it contains personal identifiable information. Data may be requested through the NCDHHS, Division of Public Health with proper approvals.

Data from EPA's CMAQ EQUATES model are publicly available. Format: Birth certificate data from the State Center for Health Statistics of the NC Department of Health and Human Services linked with data from the Birth Defects Monitoring Program (NC BDMP) to create a birth cohort of all infants born in NC between 2003-2015. The NC BDMP is an active surveillance system that follows NC births to obtain birth defect diagnoses up to 1 year after the date of birth as well as identify infant deaths during the first year of life and include relevant information from the death certificate.

EPA's publicly available CMAQ EQUATES model provided data on predicted SO2 concentrations over critical windows of gestation. The model predicts daily 1-hour maximum SO2 concentrations for 12 km x 12 km grid cells across the study area.

This dataset is associated with the following publication: Wilkie, A., T. Luben, K. Rappazzo, K. Foley, C. Woods, M. Serre, D. Richardson, and J. Daniels. Long-term ambient sulfur dioxide exposure during gestation and preterm birth in North Carolina, 2003-2015. ATMOSPHERIC ENVIRONMENT. Elsevier B.V., Amsterdam, NETHERLANDS, 333(September 15): 120669, (2024).

Access & Use Information

Restricted: This dataset can only be accessed or used under certain conditions. License: See this page for license information.

Downloads & Resources

No file downloads have been provided. The publisher may provide downloads in the future or they may be available from their other links.

References

https://doi.org/10.1016/j.atmosenv.2024.120669
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11360850

Dates

Metadata Created Date February 17, 2025
Metadata Updated Date February 17, 2025

Metadata Source

Harvested from EPA ScienceHub

Additional Metadata

Resource Type Dataset
Metadata Created Date February 17, 2025
Metadata Updated Date February 17, 2025
Publisher U.S. EPA Office of Research and Development (ORD)
Maintainer
Identifier https://doi.org/10.23719/1532013
Data Last Modified 2024-06-24
Rights EPA Category: Personally Identifiable Information (PII), NARA Category: Privacy
Public Access Level restricted public
Bureau Code 020:00
Schema Version https://project-open-data.cio.gov/v1.1/schema
Harvest Object Id 09103234-c6f3-4232-82ca-b4e165757505
Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
Harvest Source Title EPA ScienceHub
License https://pasteur.epa.gov/license/sciencehub-license-non-epa-generated.html
Program Code 020:000
Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
Related Documents https://doi.org/10.1016/j.atmosenv.2024.120669, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11360850
Source Datajson Identifier True
Source Hash 6deec767deaa1ba7a80c2a14cf9a371287454e6127aff7a276a5d49759c7cc76
Source Schema Version 1.1

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