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Compared with an algorithm like [[adaptive rejection sampling]]<ref name=":0">{{Cite journal |last=Gilks |first=W. R. |last2=Wild |first2=P. |date=1992-01-01 |title=Adaptive Rejection Sampling for Gibbs Sampling |journal=Journal of the Royal Statistical Society. Series C (Applied Statistics) |volume=41 |issue=2 |pages=337–348 |doi=10.2307/2347565 |jstor=2347565}}</ref> that directly generates independent samples from a distribution, Metropolis–Hastings and other MCMC algorithms have a number of disadvantages:
* The samples are
* Although the Markov chain eventually converges to the desired distribution, the initial samples may follow a very different distribution, especially if the starting point is in a region of low density. As a result, a ''burn-in'' period is typically necessary,<ref>{{Cite book |title=Bayesian data analysis |date=2004 |publisher=Chapman & Hall / CRC |others=Gelman, Andrew |isbn=978-1584883883 |edition=2nd |___location=Boca Raton, Fla. |oclc=51991499}}</ref> where an initial number of samples are thrown away.
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