Lander–Green algorithm: Difference between revisions

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Revision as of 06:23, 21 April 2013

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The '''Lander–Green algorithm''' is an algorithm, due to [[Eric Lander]] and [[Philip Green (geneticist)| Philip Green]] for computing the [[likelihood]] of observed genotype data given a [[Pedigree chart|pedigree]]. It is appropriate for relatively small pedigrees and a large number of markers. It is used in the analysis of [[genetic linkage]].<ref name="Lander and Green (1987)"> Lander, E.S. and Green, P. (1987) [http://www.pnas.org/content/84/8/2363.full.pdf "Construction of multilocus genetic linkage maps in humans"], ''Proceedings of the National Academy of Sciences'', 84 (8), 2363&ndash;2367</ref><ref name="Abecasis 2005">

Abecasis, G.R., Wigginton, J.E. (2005) [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1271385/ "Handling Marker-Marker Linkage Disequilibrium: Pedigree Analysis with Clustered Markers"], ''Am J Hum Genet.'', 77(5), 754&ndash;767.

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<references/>

{{DEFAULTSORT:Lander-Green algorithm}}

[[Category:Genetic epidemiology]]

[[Category:Statistical genetics]]

[[Category:Genetic linkage analysis]]

[[Category:Statistical algorithms]]

{{genetics-stub}}