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==Negative effect on larger writes==
The algorithm applies to data of any size. If the data in a single write spans ''2n'' packets, the last packet will be withheld, waiting for the ACK for the previous packet.<ref>{{cite web|url=http://www.stuartcheshire.org/papers/NagleDelayedAck/ |title=TCP Performance problems caused by interaction between Nagle's Algorithm and Delayed ACK |publisher=Stuartcheshire.org |date= |accessdate=November 14, 2012}}</ref> In any request-response application protocols where request data can be larger than a packet, this can artificially impose a few hundred milliseconds latency between the requester and the responder, even if the requester has properly buffered the request data. Nagle's algorithm
In general, since Nagle's algorithm is only a defense against careless applications, it will not benefit a carefully written application that takes proper care of buffering; the algorithm has either no effect, or negative effect on the application.
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