The '''cardiac neural crest''' is a form of [[neural crest]].<ref name="urlThe Neural Crest">{{cite web |url=http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=dbio.section.3109 |title=The Neural Crest |format= |work= |accessdate=2009-05-31}}</ref>
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The '''cardiac neural crest''' develops from the dorsal neural tube.<ref name="pmid18292601">{{cite journal |author=Sun X, Zhang R, Lin X, Xu X |title=Wnt3a regulates the development of cardiac neural crest cells by modulating expression of cysteine-rich intestinal protein 2 in rhombomere 6 |journal=Circ. Res. |volume=102 |issue=7 |pages=831–9 |year=2008 |month=April |pmid=18292601 |doi=10.1161/CIRCRESAHA.107.166488 |url=http://circres.ahajournals.org/cgi/pmidlookup?view=long&pmid=18292601}}</ref> It overlaps the vagal neural crest and migrates to populate the [[branchial arches|pharyngeal arches]] 3, 4 and 6 (producing structures in the head) and to the [[heart]], forming connective tissue that separates the great vessels of the heart.
:''Other Migration Locations:''
:*Into the [[pharyngeal arches]] and [[Truncus arteriosus (embryology)]], forming the [[aorticopulmonary septum]]<ref name="pmid10725237">{{cite journal |author=Jiang X, Rowitch DH, Soriano P, McMahon AP, Sucov HM |title=Fate of the mammalian cardiac neural crest |journal=Development |volume=127 |issue=8 |pages=1607–16 |year=2000 |month=April |pmid=10725237 |doi= |url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=10725237}}</ref> and the [[smooth muscle]] of [[great arteries]].
:*Anterior of the aorta to become the four [[pre-aortic ganglia]] ([[celiac ganglion]], [[superior mesenteric ganglion]], [[inferior mesenteric ganglion]] and [[aortical renal ganglia]])
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[[Notch2]] plays an important role in development.<ref name="pmid18330927">{{cite journal |author=Varadkar P, Kraman M, Despres D, Ma G, Lozier J, McCright B |title=Notch2 is required for the proliferation of cardiac neural crest-derived smooth muscle cells |journal=Dev. Dyn. |volume=237 |issue=4 |pages=1144–52 |year=2008 |month=April |pmid=18330927 |doi=10.1002/dvdy.21502 |url=http://dx.doi.org/10.1002/dvdy.21502}}</ref>
