Kokko and Rector Model: Difference between revisions

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{{more footnotes|date=December 2013}}

The '''kokko and rector model''' is a theory to explain how a gradient is generated in the inner [[medulla]].

ItThe was'''Kokko previouslyand thoughtRector thatmodel''' is a theory explaining the mechanism of generation of a gradient wasin generatedthe [[inner medulla]] byof the [[kidney]]. Unlike earlier theories explaining the mechanism using counter current mechanism (isas is the case in the outer [[outer medulla]])., Butthe itdriving force for salt reabsorption is stated to be urea accumulation. It has been provenproved that thiscounter current mechanism cannot be the case in the inner [[inner medulla]], since there are no salt pumps, and the [[cell membrane]] is too [[Semipermeable membrane|permeable]] to salt.{{clarify|date=December 2013}}

==History==

The '''kokko and rector model''' suggests that in the inner medulla the driving force for salt reabsorption is urea accumulation.

It has been proposed by Juha Kokko and Floyd Rector Jr. in 1972.<ref name="pmid4657922">{{cite journal|title=Countercurrent multiplication system without active transport in inner medulla|year=1972|last1=Kokko|first1=Juha P.|last2=Rector Jr.|first2=Floyd C.|journal=Kidney International|volume=2|issue=4|pages=214–23|doi=10.1038/ki.1972.97|pmid=4657922|doi-access=free}}</ref>

==References==

{{reflist}}

==Further reading==

* {{cite book|title=Vasopressin|url=https://books.google.com/books?id=plW1j20qw5AC&pg=PA408|year=1993|publisher=John Libbey Eurotext|isbn=978-2-7420-0031-9|pages=408–}}

* {{cite journal|last=Britton|first=KE|author2=Cage, PE |author3=Carson, ER |title=A 'bootstrap' model of the renal medulla|journal=Postgrad Med J|date=May 1976|volume=52|issue=607|pages=279–284|pmc=2496524|doi=10.1136/pgmj.52.607.279|pmid=959103}}

* {{cite journal|title=Effect of peristaltic contractions of the renal pelvic wall on solute concentrations of the renal inner medulla in the hamster|year=2005|last1=Pruitt|first1=M. E. C.|journal=AJP: Renal Physiology|volume=290|issue=4|pages=F892–6|last2=Knepper|first2=MA|last3=Graves|first3=B|last4=Schmidt-Nielsen|first4=B|pmc=1400599|doi=10.1152/ajprenal.00323.2005|pmid=16234309}}

[[Category:Renal physiology]]

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