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'''Barry James Marshall''', [[Order of Australia|AC]] [[Fellow of the Royal Society|FRS]] [[Fellow of the Australian Academy of Science|FAA]] (born [[30 September]] [[1951]]) is an [[Australia]]n [[physician]], [[Nobel Prize]] winner, and Professor of Clinical Microbiology at the [[University of Western Australia]]. He is well-known for proving that the bacteria ''[[Helicobacter pylori]]'' is the cause of most [[Peptic ulcer|stomach ulcers]], reversing decades of medical doctrine which held that ulcers were caused by stress, spicy foods, and too much acid.
==Early years==
Marshall was born in [[Kalgoorlie, Western Australia|Kalgoorlie]], [[Western Australia]] and lived in Kalgoorlie and [[Carnarvon, Western Australia|Carnarvon]] until moving to [[Perth, Western Australia|Perth]] at seven. He attended High School at [[Newman College (Perth)|Newman College]] and the [[University of Western Australia]], where he received a [[Bachelor of Medicine and Surgery|Bachelor of Medicine, Bachelor of Surgery]] in 1975. He married his wife Adrienne in 1972.<ref name=autobiography>{{cite web
| last =Barry
| first =Marshall
| title =Autobiography
| work =
| publisher =[[Nobel Foundation]]
| date =2005
| url =http://nobelprize.org/nobel_prizes/medicine/laureates/2005/marshall-autobio.html
| accessdate = 2007-01-28 }}</ref><ref>In 1972 he was also a state [[yo-yo]] champion.</ref>
==Life and research==
In 1979 Marshall was appointed as a Registrar in Medicine at the [[Royal Perth Hospital]]. He met [[Robin Warren]], a pathologist interested in [[gastritis]], during internal medicine fellowship training at Royal Perth Hospital in 1981. Together, the pair studied the presence of spiral bacteria in association with gastritis. The following year (1982), they performed the initial culture of ''H. pylori'' and developed their hypothesis related to the bacterial cause of peptic ulcer and gastric cancer.<ref name=autobiography/> It has been claimed that the ''H. pylori'' theory was ridiculed by the establishment scientists and doctors, who did not believe that any bacteria could live in the acidic stomach. Marshall has been quoted as saying in 1998 that "Everyone was against me, but I knew I was right".<ref>{{cite web
| title =Barry Marshall Interview, H. Pylori and the Making of a Myth
| publisher =Academy of Achievement
| date =[[May 23]] [[1998]]
| url =http://www.achievement.org/autodoc/printmember/mar1int-1
| accessdate =2007-01-28 }}</ref> On the other hand, it has also been argued that medical researchers showed a proper degree of skepticism until the ''H. pylori'' hypothesis could be proved.<ref>{{cite web
| last=Atwood
| first=Kimball C.
| title =Bacteria, Ulcers, and Ostracism?
| publisher =[[Skeptical Inquirer]]
| date =November 2004
| url =http://www.achievement.org/autodoc/printmember/mar1int-1
| accessdate =2007-01-28 }}</ref>
After failed attempts to infect piglets in 1984, Marshall drank a petri-dish of the bacteria and soon developed gastritis with [[achlorhydria]]. Symptoms included vague stomach discomfort, nausea, vomiting and [[halitosis]]. On the 14th day of the infection, biopsies of Marshall's stomach did not reveal any bacteria - so spontaneous eradication may have occurred. However, on the insistence of his wife, he did take antibiotics immediately after that endoscopy so there was no way of double-checking the negative result. Interestingly, he did not develop antibodies to H.pylori, suggesting that [[innate immunity]] can sometimes eradicate acute H.pylori infection. His illness and recovery, based on a culture of organisms extracted from a patient, fulfilled [[Koch's postulates]] for ''H. pylori'' and gastritis, but not for peptic ulcer. This experiment was published in 1985 in the [[Medical Journal of Australia]]<ref>[http://www.mja.com.au/ Medical Journal of Australia]</ref> and is among the most cited articles from the journal.<ref>{{cite journal
| last =Van Der Weyden
| first =Martin B
| authorlink =
| coauthors =Ruth M Armstrong and Ann T Gregory
| title =The 2005 Nobel Prize in Physiology or Medicine
| journal =Medical Journal of Australia
| volume =183
| issue =11/12
| pages =612-614
| publisher =Medical Journal of Australia
| date =2005
| url =http://www.mja.com.au/public/issues/183_11_051205/van11000_fm.html#0_i1091639
| accessdate = 2007-01-28 }}</ref>
After this work at [[Fremantle Hospital]], Marshall did research at Royal Perth Hospital (1985-86) and at the [[University of Virginia]], USA (1986-1996), before returning to Australia. He held a Burnet Fellowship at the University of Western Australia from 1998-2003<ref>{{cite web
| title =Professor Barry Marshall
| publisher =University of Western Australia
| date =[[28 July]] [[2006]]
| url =http://www.postgraduate.uwa.edu.au/home/prospective/heroes/marshall
| accessdate =2007-01-28 }}</ref> and continues research related to ''H. pylori'' and runs the H.pylori Research Laboratory at UWA.<ref>{{cite web
| first=Barry
| last=Marshall
| title =Helicobacter pylori Research Laboratory
| publisher =University of Western Australia
| date =[[August 26]] [[2002]]
| url =http://www.hpylori.com.au
| accessdate =2007-01-28 }} His home page and various links can also be found there.</ref> He has been criticised for appearing in an [[informercial]] for a "fact free" health book, but he has defended himself from this criticism.<ref>{{cite web
| title =What the heck is this Nobel Prize winner doing in a shady Infomercial?
| date =[[2006-09-30]]
| newsgroup =The Permanent Press
| url =http://thepermanentpress.blogspot.com/2006/09/what-heck-is-this-nobel-prize-winner.html
| accessdate =2007-01-28 }}</ref><ref>{{cite web
| title =About that naughty book I promoted
| first=Barry
| last=Marshall
| date =[[2007-01-20]]
| url =http://barryjmarshall.blogspot.com/2007/01/about-that-naughty-book-i-promoted.html
| accessdate = 2007-01-28 }}</ref>
==Awards and honours==
In 2005, the [[Karolinska Institutet|Karolinska Institute in Stockholm]] awarded the [[Nobel Prize in Physiology or Medicine]] to Dr. Marshall and his long-time collaborator Dr. Warren "for their discovery of the bacterium ''Helicobacter pylori'' and its role in [[gastritis]] and peptic ulcer disease".<ref name=award>{{cite web
| title =The Nobel Prize in Physiology or Medicine 2005
| publisher =[[Nobel Foundation]]
| date =2005
| url =http://nobelprize.org/nobel_prizes/medicine/laureates/2005/illpres/
| accessdate = 2007-01-28 }}</ref>
Marshall also received the Warren Alpert Prize in 1994, the [[Australian Medical Association]] Award in 1995, [[Albert Lasker Award for Clinical Medical Research]] in 1995 and the [[Gairdner Foundation International Award]] in 1996, the Paul Ehrlich Prize in 1997, the [[Dr A.H. Heineken Prize]] for Medicine in 1998, the Florey Medal in 1998, the [[Buchanan Medal]] of the [[Royal Society]] in 1998, Benjamin Franklin Medal for Life Sciences in 1999, the Keio Medical Science Prize in 2002 and the Australian [[Centenary Medal]] in 2003.<ref>{{cite web
| title =Curriculum Vitae
| publisher =[[Nobel Foundation]]
| date =2005
| url =http://nobelprize.org/nobel_prizes/medicine/laureates/2005/marshall-cv.html
| accessdate = 2007-01-28 }}</ref>
He was made a [[Companion of the Order of Australia]] in 2007.<ref>{{cite web
| title =It's an Honour
| publisher =[[Government of Australia]]
| date =[[26 January]] [[2007]]
| url =http://www.itsanhonour.gov.au/honours/honour_roll/search.cfm?aus_award_id=1133678&search_type=quick&showInd=true
| accessdate = 2007-01-28 }}</ref>
==See also==
*[[Timeline of peptic ulcer disease and Helicobacter pylori]]
==Notes==
{{reflist}}
==References==
* Marshall BJ. ''Unidentified curved bacillus on gastric epithelium in active chronic gastritis.'' Lancet 1983;1((8336):1273-1275. PMID 6134060.
* Marshall BJ, Warren JR. ''Unidentified curved bacilli in the stomach patients with gastritis and peptic ulceration.'' Lancet 1984;1(8390):1311-1315. PMID 6145023.
*{{cite news
| last =Sweet
| first =Melissa
| title =Smug as a bug
| publisher =[[The Sydney Morning Herald]]
| date =[[August 2]] [[1997]]
| url =http://www.vianet.net.au/~bjmrshll/features2.html
| accessdate = 2007-01-28 }}
==External links==
* [http://www.helico.com/cgi-bin/yabb/YaBB.pl?board=;action=login The Helicobacter Foundation Discussion Pages]
* [http://www.hpylori.com.au The Helicobacter pylori Research Laboratory]
* [http://www.helico.com The Helicobacter Foundation]
{{Nobel Prize in Physiology or Medicine Laureates 2001-2025}}
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