Nkx2-2as: Difference between revisions

Revision as of 14:06, 4 June 2016

Latest revision as of 22:18, 2 December 2023

(7 intermediate revisions by 5 users not shown)

Line 25:

| GenLoc_start = 146987678

| GenLoc_end = 147179556

}}__NOTOC__

}}

'''Nkx2-2as''' (Nkx2-2 antisense) is a [[long non-coding RNA]]. It is located in the [[cytoplasm]] of the [[cell (biology)|cell]]. Nkx2-2as is involved in [[Neural development]]. Overexpression of Nkx2-2as results in increased levels of expression of the [[homeobox]] gene [[NKX2-2|Nkx2-2]] and enhances induction of the [[Cellular differentiation|differentiation]] of [[oligodendrocytes]].<ref name="pmid18538132">{{cite journal |vauthors=Tochitani S, Hayashizaki Y |title=Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation |journal=Biochem. Biophys. Res. Commun. |volume=372 |issue=4 |pages=691–6 |date=August 2008 |pmid=18538132 |doi=10.1016/j.bbrc.2008.05.127 |url=}}</ref><ref name=Szyma>{{Citation

| title = Noncoding RNAs in the Development, Function and Pathologies of the Central Nervous System

| url = http://www.springerlink.com/index/l4016j727530qm70.pdf

| year = 2009

| journal = Therapeutic Ribonucleic Acids in Brain Tumors

| pages = 453–470

| last1 = Szyma | first1 = .

| last2 = Nacute | first2 = .

| last3 = Ski | first3 = M.

| last4 = Barciszewski | first4 = J.

| accessdate = 2011-03-25 }}</ref><ref name="pmid20137068">{{cite journal |vauthors=Mercer TR, Qureshi IA, Gokhan S, Dinger ME, Li G, Mattick JS, Mehler MF |title=Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation. |journal=BMC Neurosci |volume=11 |issue= |pages=14 |year=2010 |pmid=20137068 |doi=10.1186/1471-2202-11-14 |pmc=2829031}}</ref><ref name="pmid20380817">{{cite journal |vauthors=Qureshi IA, Mattick JS, Mehler MF |title=Long non-coding RNAs in nervous system function and disease. |journal=Brain Res |volume=1338 |issue= |pages=20–35 |year=2010 |pmid=20380817 |doi=10.1016/j.brainres.2010.03.110 |pmc=2883659}}</ref> Besides Nkx2-2, Nkx2-2as may also regulate the expression of other genes.<ref name="pmid18538132" /><ref name=Szyma />

__NOTOC__

'''Nkx2-2as''' (Nkx2-2 antisense) is a [[long non-coding RNA]]. It is located in the [[cytoplasm]] of the [[cell (biology)|cell]]. Nkx2-2as is involved in [[Neural development]]. Overexpression of Nkx2-2as results in increased levels of expression of the [[homeobox]] gene [[NKX2-2|Nkx2-2]] and enhances induction of the [[Cellular differentiation|differentiation]] of [[oligodendrocytes]].<ref name="pmid18538132">{{cite journal | vauthors = Tochitani S, Hayashizaki Y | title = Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation | journal = Biochemical and Biophysical Research Communications | volume = 372 | issue = 4 | pages = 691–6 | date = August 2008 | pmid = 18538132 | doi = 10.1016/j.bbrc.2008.05.127 }}</ref><ref name="Szyma">{{cite book | vauthors = Szymański M, Barciszewski J | chapter = Noncoding RNAs in the Development, Function and Pathologies of the Central Nervous System | veditors = Erdmann VA, Reifenberger G, Barciszewski J | title = Therapeutic Ribonucleic Acids in Brain Tumors | url = https://archive.org/details/therapeuticribon00erdm | url-access = limited | date = 2009 | pages = [https://archive.org/details/therapeuticribon00erdm/page/n459 453]–470 | publisher = Springer | ___location = Berlin, Heidelberg | doi = 10.1007/978-3-642-00475-9_20 | isbn = 978-3-642-00474-2 }}</ref><ref name="pmid20137068">{{cite journal | vauthors = Mercer TR, Qureshi IA, Gokhan S, Dinger ME, Li G, Mattick JS, Mehler MF | title = Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation | journal = BMC Neuroscience | volume = 11 | pages = 14 | date = February 2010 | pmid = 20137068 | pmc = 2829031 | doi = 10.1186/1471-2202-11-14 | doi-access = free }}</ref><ref name="pmid20380817">{{cite journal | vauthors = Qureshi IA, Mattick JS, Mehler MF | title = Long non-coding RNAs in nervous system function and disease | journal = Brain Research | volume = 1338 | pages = 20–35 | date = June 2010 | pmid = 20380817 | pmc = 2883659 | doi = 10.1016/j.brainres.2010.03.110 }}</ref> Besides Nkx2-2, Nkx2-2as may also regulate the expression of other genes.<ref name="pmid18538132" /><ref name="Szyma" />

==See also==

== See also ==

* [[Long non-coding RNA]]

== References ==

{{reflist}}

== Further reading ==

{{refbegin}}

* {{cite journal |author vauthors = Mattick JS | title = The genetic signatures of noncoding RNAs | journal =PLoS Genet.PLOS Genetics | volume = 5 | issue = 4 | pages = e1000459 | date = April 2009 | pmid = 19390609 | pmc = 2667263 | doi = 10.1371/journal.pgen.1000459 |url doi-access = free }}

{{refend}}

== External links ==

* [http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=201818 MGI entry for Nkx2-2as]