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{{infobox biodatabase
The '''Model Organism Protein Expression Database''' (MOPED, http://moped.proteinspire.org) is an expanding proteomics resource that supports rapid browsing of protein expression information from publicly available studies on model organisms and humans. MOPED is designed to simplify the comparison and sharing of proteomics data for the greater research community. MOPED uniquely provides protein level expression data, meta- analysis capabilities and quantitative data from standardized analysis. Data can be queried for specific proteins, browsed based on organism, tissue, localization and condition and sorted by false discovery rate and expression. MOPED empowers users to visualize their own expression data and compare it with existing studies. Further, MOPED links to various protein and pathway data- bases, including [[GeneCards]], [http://www.pantherdb.org/ Panther], [[Entrez]], [[UniProt]], [[KEGG]], [http://www.theseed.org/wiki/Home_of_the_SEED SEED], and [[Reactome]]. Protein identifiers are integrated from GeneCards (cross-referenced with MOPED), [[Genbank|GI]], [[RefSeq]], [http://www.ebi.ac.uk/ena/about/locus_tag Locus Tag], [[UniProt]], [[WormBase]], and [http://en.wikipedia.org/wiki/Saccharomyces_Genome_Database SGD]. The current version of MOPED (MOPED 2.0, 2012) contains over 43000 proteins with at least one spectral match and more than 11 million high certainty spectra. MOPED is developed and supported by the [http://kolkerlab.proteinspire.org/ Kolker] team at [http://www.seattlechildrens.org/research/ Seattle Children's Research Institute].
|title = MOPED
|logo =[[File:Database.png]]
|description = MOPED enables discoveries through consistently processed multi-omics data
|scope =
|organism =
|center = [[Seattle Children's Research Institute]]
|laboratory =
|author = Roger Higdon
|citation = Higdon R, ''et al''.<ref name="pmid24350770">{{cite journal |author1=Higdon R |author2=Stewart E |author3=Stanberry L |author4=Haynes W |author5=Choiniere J |author6=Montague E |author7=Anderson N |author8=Yandl Y |author9=Janko I |author10=Broomall W |author11=Fishilevich S |author12=Lancet D |author13=Kolker N |author14=Eugene Kolker. | title = MOPED enables discoveries through consistently processed proteomics data. | journal = J Proteome Res | volume = 13 | issue = 1 | pages = 107–113 |date=Jan 2014 | pmid = 24350770 | doi = 10.1021/pr400884c |pmc=4039175 }}</ref>
|released = 2012
|standard =
|format =
|url = [https://www.proteinspire.org/MOPED/ MOPED]
|download =
|webservice =
|sql =
|sparql =
|webapp =
|standalone =
|license =
|versioning =
|frequency =
|curation =
|bookmark =
|version=
}}
The '''Multi-Omics Profiling Expression Database''' ('''MOPED''') was an expanding [[Multiomics|multi-omics]] resource that supports rapid browsing of [[transcriptomics]] and [[proteomics]] information from publicly available studies on [[model organism]]s and humans.<ref>{{cite journal |vauthors=Kolker E, Higdon R, Haynes W, Welch D, Broomall W, Lancet D, Stanberry L, Kolker N | title = MOPED: Model Organism Protein Expression Database | journal = Nucleic Acids Res. | volume = 40 | issue = Database issue | pages = D1093–9 |date=Jan 2012 | pmid = 22139914 | pmc = 3245040 | doi = 10.1093/nar/gkr1177 }}</ref> As to date (2021) it has ceased activities and is unaccessible online.<ref>{{cite web |url=https://www.proteinspire.org/MOPED/ |title=Start Moped Web Application |website=www.proteinspire.org |url-status=dead |archive-url=https://web.archive.org/web/20140422231720/https://www.proteinspire.org/MOPED/ |archive-date=2014-04-22}} </ref>
 
==Systematic Protein Investigative Research Environment==
TheMOPED '''Modelis Organismdesigned to simplify the comparison and sharing of data for the greater research community. MOPED employs the standardized analysis pipeline [[Systematic Protein ExpressionInvestigative Database'''Research (MOPEDEnvironment|SPIRE]]<ref>{{cite journal |vauthors=Kolker E, http://moped.proteinspire.org)Higdon isR, anMorgan expandingP, proteomicsSedensky resourceM, thatWelch supportsD, rapidBauman browsingA, ofStewart E, Haynes W, Broomall W, Kolker N | title = SPIRE: Systematic protein expressioninvestigative informationresearch fromenvironment publicly| availablejournal studies= onJ modelProteomics organisms| andvolume humans.= MOPED75 is| designedissue to= simplify1 the| comparisonpages and= sharing122–6 of|date=December proteomics2011 data| forpmid the= greater21609792 research| communitydoi = 10.1016/j.jprot.2011.05.009 MOPED}}</ref> to uniquely providesprovide protein level absolute and relative expression data, meta- analysis capabilities and quantitative data. Processed relative expression transcriptomics data were obtained from standardizedthe analysisGene Expression Omnibus (GEO). Data can be queried for specific proteins and genes, browsed based on organism, tissue, localization and condition, and sorted by false discovery rate and expression. MOPED empowers users to visualize their own expression data and compare it with existing studies. Further, MOPED links to various protein and pathway data- bases, including [[GeneCards]], [http://www.pantherdb.org/ Panther], [[Entrez]], [[UniProt]], [[KEGG]], [http://www.theseed.org/wiki/Home_of_the_SEED SEED], and [[Reactome]]. Protein and gene identifiers are integrated from GeneCards (cross-referenced with MOPED), [[Genbank|GI]], [[RefSeq]], [http://www.ebi.ac.uk/ena/about/locus_tag Locus Tag], [[UniProt]], [[WormBase]], and [http://en.wikipedia.org/wiki/Saccharomyces_Genome_DatabaseSaccharomyces Genome Database (SGD]). The current version of MOPED (MOPED 2.05, 20122014) contains overapproximately 430005 proteinsmillion withtotal atrecords leastincluding one~260 spectral matchexperiments and more than 11 million high certainty~390 spectraconditions. MOPED is developed and supported by the [http://kolkerlab.proteinspire.org/ Kolker] team at [http://www.seattlechildrens.org/research/ [Seattle Children's Research Institute]].
 
==Model Organism Protein Expression Database==
MOPED was previously known as the Model Organism Protein Expression Database, before changing its name to the Multi-Omics Profiling Expression Database.<ref>{{Cite journal |last1=Kolker |first1=Eugene |last2=Higdon |first2=Roger |last3=Haynes |first3=Winston |last4=Welch |first4=Dean |last5=Broomall |first5=William |last6=Lancet |first6=Doron |last7=Stanberry |first7=Larissa |last8=Kolker |first8=Natali |date=2011-12-01 |title=MOPED: Model Organism Protein Expression Database |url=https://doi.org/10.1093/nar/gkr1177 |journal=Nucleic Acids Research |volume=40 |issue=D1 |pages=D1093–D1099 |doi=10.1093/nar/gkr1177 |issn=1362-4962 |pmc=3245040 |pmid=22139914}}</ref><ref>{{Cite journal |last1=Montague |first1=Elizabeth |last2=Janko |first2=Imre |last3=Stanberry |first3=Larissa |last4=Lee |first4=Elaine |last5=Choiniere |first5=John |last6=Anderson |first6=Nathaniel |last7=Stewart |first7=Elizabeth |last8=Broomall |first8=William |last9=Higdon |first9=Roger |last10=Kolker |first10=Natali |last11=Kolker |first11=Eugene |date=2015-01-28 |title=Beyond protein expression, MOPED goes multi-omics |url=http://academic.oup.com/nar/article/43/D1/D1145/2439032/Beyond-protein-expression-MOPED-goes-multiomics |journal=Nucleic Acids Research |language=en |volume=43 |issue=D1 |pages=D1145–D1151 |doi=10.1093/nar/gku1175 |issn=1362-4962 |pmc=4383969 |pmid=25404128}}</ref>
 
== References ==
{{Reflist}}
Kolker E, et al, MOPED: Model Organism Protein Expression Database, Nucleic Acids Research, 2012, 40(D1): 1093-1099. PMID 22139914
 
== Further reading ==
Kolker E, et al, SPIRE: Systematic Protein Investigative Research Environment, Journal of Proteomics, 2011, 75(1): 122-126. PMID 21609792
{{refbegin}}
* {{cite journal |vauthors=Stelzer G, Dalah I, Stein TI, Satanower Y, Rosen N, Nativ N, Oz-Levi D, Olender T, Belinky F, Bahir I, Krug H, Perco P, Mayer B, Kolker E, Safran M, Lancet D | title = In-silico human genomics with GeneCards | journal = Hum. Genomics | volume = 5 | issue = 6 | pages = 709–17 |date=October 2011 | pmid = 22155609 | pmc = 3525253 | doi = 10.1186/1479-7364-5-6-709 | doi-access = free }}
Stelzer G, et al, In-silico human genomics with GeneCards, Human Genomics, 2011, 5(6): 709–717. PMID 22155609
{{refend}}
 
[[Category:Biological databases]]
[[Category:Proteomics]]
[[Category:Omics]]