Talk:Restriction fragment length polymorphism: Difference between revisions

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==Untitled==

This article is lacking moleular level details in describing riflips. more examples and relevant ideas should be given. it's a good start but much could be added.

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:You are right in thinking the two terms are related: in fact, VNTRs were often detected as RFLPs by Southern hybridization, though now more usually a PCR technique is used. The term VNTR refers to the variable sequence rather than to the method used to detect it. - [[User:Nunh-huh|Nunh-huh]] 19:59, 30 May 2006 (UTC)

== Discovery ==

````Botstein, White, Skolnic, Davis (1980) Am. J Hum. Genet. 32(3) 314 defined RFLPs before the 1985 Jeffries citation listed currently <small><span class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:GCdeQR|GCdeQR]] ([[User talk:GCdeQR|talk]] • [[Special:Contributions/GCdeQR|contribs]]) 06:46, 15 May 2009 (UTC)</span></small><!-- Template:Unsigned --> <!--Autosigned by SineBot-->

:Any idea if that's the first mention of it? Can we attribute its first use as a full assay to Botstein ''et al.'' in 1980? [[User:Qwerty0|Qwerty0]] ([[User talk:Qwerty0|talk]]) 15:57, 20 September 2018 (UTC)

::Oops, sorry, Botstein ''et al.'' didn't invent RFLP; they just referred to it. However, ''they'' claim that [http://symposium.cshlp.org/content/39/439 Grodzicker ''et al.'' 1974] did. [[User:Qwerty0|Qwerty0]] ([[User talk:Qwerty0|talk]]) 16:58, 20 September 2018 (UTC)

== Restriction Enzyme Site link ==

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:Seems like a good place for it to link to, so now it does. Thanks for pointing that out. - <span style="font-family: cursive">[[User:Nunh-huh|Nunh-huh]]</span> 21:59, 21 February 2011 (UTC)

== History largely missing ==

Like a lot of technical articles on ''Wikipedia'', this one is spectacularly weak on history. Not just who discovered it, but when it became widely used, and when it became obsolescent. The science end of the article is great; the social end is largely absent. If anyone can supply just a few sentences charting its discovery, emergence, expanded use, and then obsolescence, that would be great. [[User:Theonemacduff|Theonemacduff]] ([[User talk:Theonemacduff|talk]]) 00:17, 4 November 2019 (UTC)