Talk:DNA microarray: Difference between revisions

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==Terms==

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Better to use the term probe than feature, because it is microarray (northern blot)-specific. <small><span class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Pain-proof|Pain-proof]] ([[User talk:Pain-proof|talk]] • [[Special:Contributions/Pain-proof|contribs]]) 01:07, 7 January 2015 (UTC)</span></small><!-- Template:Unsigned --> <!--Autosigned by SineBot-->

== "citation needed" ==

Under the Data analysis section is "...in the case of commercial platforms, the analysis may be proprietary.[citation needed] "

Here is one citation, where the company clearly states their algorithm is proprietary: [http://prosigna.com/x-us/overview/prosigna-algorithm/] <!-- Template:Unsigned IP --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/184.100.44.130|184.100.44.130]] ([[User talk:184.100.44.130#top|talk]]) 00:29, 9 June 2017 (UTC)</small> <!--Autosigned by SineBot-->

== Huh? ==

I like to think of myself as fairly scientifically literate, but after skimming through this page, and a couple of other web descriptions, I still don't understand what DNA chips are.

The most fundamental issue to explain seems missing: is this an actual biological sample taken from a living being (human or whatever) that's somehow affixed to a solid surface, or is this a purely synthetic pattern affixed to a microscope slide or other support? If the latter, why not just encode it into a computer program, why bother with a physical form at all?

I think that the people who've written about this (here on Wikipedia and elsewhere) know too much about the subject, and don't know how to introduce it to an audience who know nothing about it. I think the page should start with a much more basic explanation of what's being discussed. <!-- Template:Unsigned IP --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/74.104.100.218|74.104.100.218]] ([[User talk:74.104.100.218#top|talk]]) 20:53, 30 August 2019 (UTC)</small> <!--Autosigned by SineBot-->

I agree with this. It's a comprehensive article, but very difficult to get into for the beginner.

Would it be OK to rewrite the introduction using some assumptions/simplifications? Like, for example, I think it would help if the introduction just mentioned that DNA microarray can measure SNPs and gene expression, define what that is, and then briefly mention that other types exists. Because right now it's written in such a comprehensive way, keeping open to all the many different types of microarray (tilling, microRNA, etc). But that makes it hard to read. And really gene expression and SNP genotyping, is by far the largest applications by count of samples (and I'd even argue SNP genotyping alone would be the most important, given gwas+DTC industry) [[User:Yinwang888|Yinwang888]] ([[User talk:Yinwang888|talk]]) 05:32, 11 February 2020 (UTC)

: I replaced the header figure. It was very specific on a sub-aspect on where probes of gene expression microarrays bind. Instead there now is an overview video. I hope that helps. I didn't delete the previous figure though, merely moved it down a bit [[User:Lassefolkersen|LasseFolkersen]] ([[User talk:Lassefolkersen|talk]]) 10:42, 14 May 2020 (UTC)

:: Very nice video! Very illustrative. Cool that you have made a Chinese version, but your pronounciation sucks. Good thing you put in subtitles. May I ask if you are Lasse Folkersen of impute.me? I am a big fan of that site. Why is there no wikipedia article for that? [[User:Yinwang888|Yinwang888]] ([[User talk:Yinwang888|talk]]) 08:56, 27 May 2020 (UTC)