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MeO-CH<sub>2</sub>-CH<sub>2</sub>-O-(CH<sub>2</sub>-CH<sub>2</sub>-O)n-CH<sub>2</sub>-CH<sub>2</sub>-OH
PEG proved suitable for this purpose since it is soluble in a wide variety of aqueous and organic solvents and its solubility provides homogeneous reaction conditions even when the attached molecule itself is insoluble in the reaction medium. Separation from the solution of the polymer and the synthesized compounds bound to it can be achieved by precipitation and filtration. The precipitation requires concentrating the reaction solutions then diluting with [[diethyl ether]] or tert-butyl methyl ether. Under carefully controlled precipitation conditions the polymer with the bound products precipitates in crystalline form and the unwanted reagents remain in solution.
In the solid phase, S&P synthesis a single compound forms on each bead, and as a consequence, the number of compounds can't exceed the number of beads. So, the theoretical maximum number of compounds depends on the quantity of the solid support and the size of the beads. On 1 g polystyrene resin, for example, a maximum of 2 million compounds can be synthesized if the diameter of the resin beads is 90
The above limitation is completely removed if the solid support is omitted
An important modification was introduced in the synthesis of DNA encoded combinatorial libraries by Harbury and Halpin.<ref>Harbury DR, Halpin DR (2000) WO 00/23458.</ref> The solid support in their case is replaced by the encoding DNA oligomers. This makes it possible to synthesize libraries containing even trillions of components and screen them using affinity binding methods.
A different way of carrying out solution-phase S&P synthesis is applying [[scavenger resin]]s to remove the byproducts. Scavenger resins are polymers having functional groups that make it possible to react with and bind components of the excess of reagents then filtered them out from the reaction mixture<ref>Steven V. Ley, Ian R. Baxendale, Robert N. Bream, Philip S. Jackson, Andrew G. Leach, Deborah A. Longbottom, Marcella Nesi, James S. Scott, R. Ian Storer and Stephen J. Taylor Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation J. Chem. Soc., Perkin Trans. 1, 2000, 3815–4195.https://doi.org/10.1039/B006588I</ref> Two examples: a resin containing primary amino groups can remove the excess of acyl chlorides from reaction mixtures while an acyl chloride resin removes amines.
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====Synthesis in Yoctoreactor====
The yoctoreactor method introduced by Hansen et al.<ref>Margit Haahr Hansen, Peter Blakskjær, Lars Kolster Petersen, Tara Heitner Hansen, Jonas Westergaard Højfeldt, Kurt Vesterager Gothelf, Nils Jakob
====Sequence encoded routing====
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