Transporter Classification Database: Difference between revisions

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{{Short description|Classification of membrane proteins including ion channels}}

'''Transporter Classification database''' (or '''TCDB''') is an [[International Union of Biochemistry and Molecular Biology]] (IUBMB) approved classification system for membrane [[transport protein]]s including [[ion channel]]s. This classification system was designed to be analogous to the [[EC number]] system for classifying [[enzymes]], but it also uses phylogenetic information.

The '''Transporter Classification Database''' (or '''TCDB''') is an [[International Union of Biochemistry and Molecular Biology]] (IUBMB)-approved classification system for [[membrane transport protein]]s, including [[ion channel]]s.<ref>{{cite journal|last1=Saier|first1=Milton H.|last2=Reddy|first2=Vamsee S.|last3=Tamang|first3=Dorjee G.|last4=Västermark|first4=Åke|title=The Transporter Classification Database|journal=Nucleic Acids Research|date=January 2014|volume=42|issue=D1|pages=D251–D258|doi=10.1093/nar/gkt1097|pmid=24225317|url= |pmc=3964967}}</ref><ref>{{cite journal|last1=Saier|first1=M. H.|last2=Yen|first2=M. R.|last3=Noto|first3=K.|last4=Tamang|first4=D. G.|last5=Elkan|first5=C.|title=The Transporter Classification Database: recent advances|journal=Nucleic Acids Research|date=1 January 2009|volume=37|issue=Database|pages=D274–D278|doi=10.1093/nar/gkn862|url= |pmid=19022853|pmc=2686586}}</ref><ref>{{cite journal|last1=Saier|first1=M. H.|last2=Tran|first2=C. V.|last3=Barabote|first3=R. D.|title=TCDB: the Transporter Classification Database for membrane transport protein analyses and information|journal=Nucleic Acids Research|date=1 January 2006|volume=34|issue=90001|pages=D181–D186|doi=10.1093/nar/gkj001|url= |pmid=16381841|pmc=1334385}}</ref>

==Classification==

The upper level of classification and a few examples of proteins with known 3D structure:

'''===1. [[Ion channel|Channels/Pores''']] and pores===

**[[Voltage-gated ion channel]] like, including [[potassium channel]]s KcsA and KvAP, and [[inward-rectifier potassium ion channel]] Kirbac [http://opm.phar.umich.edu/families.php?superfamily=8]

**[[Large-conductance mechanosensitive channel, MscL]] [http://opm.phar.umich.edu/families.php?superfamily=12]

**[[Mechanosensitive ion channel|Small-conductance mechanosensitive ion channel (MscS)]] [http://opm.phar.umich.edu/families.php?superfamily=11]

**[[Magnesium transporters|CorA metal ion transporters]] [http://opm.phar.umich.edu/families.php?superfamily=72]

**[[Ligand-gated ion channel]] of [[neurotransmitter]] receptors ([[acetylcholine receptor]]) [http://opm.phar.umich.edu/families.php?superfamily=14]

**[[Aquaporin]]s [http://opm.phar.umich.edu/families.php?superfamily=7]

**[[Chloride channel]]s [http://opm.phar.umich.edu/families.php?superfamily=10]

**Outer membrane auxiliary proteins (polysaccharide transporter) [http://opm.phar.umich.edu/families.php?superfamily=188]

**[[Porin (protein)|Porins]] and some other [[beta barrel]] proteins of [[outer membrane]]s

====1.A α-type channels====

'''2. Electrochemical Potential-driven transporters'''

* 1.A.1 [[Voltage-gated ion channel|Voltage-gated ion channel superfamily]]

**[[Mitochondrial]] [[carrier protein]]s [http://opm.phar.umich.edu/families.php?superfamily=21]

* 1.A.2 [[inward-rectifier K+ channel|Inward-rectifier K⁺ channel family]]

**Major Facilitator Superfamily (Glycerol-3-hosphate transporter, Lactose [[permease]], and Multidrug transporter EmrD) [http://opm.phar.umich.edu/families.php?superfamily=15]

* 1.A.3 [[Ryanodine-inositol-1,4,5-trisphosphate receptor Ca2+ channel|Ryanodine-inositol-1,4,5-trisphosphate receptor Ca²⁺ channel family]]

**Resistance-nodulation-cell division (multidrug [[efflux]] transporter AcrB, see [[multidrug resistance]])[http://opm.phar.umich.edu/families.php?superfamily=16]

* 1.A.4 [[Transient receptor potential Ca2+ channel|Transient receptor potential Ca²⁺ channel family]]

**Dicarboxylate/amino acid:cation symporter (proton glutamate symporter) [http://opm.phar.umich.edu/families.php?superfamily=20]

* 1.A.5 [[Polycystin cation channel family]]

**Monovalent cation/proton antiporter (Sodium/proton antiporter 1 NhaA) [http://opm.phar.umich.edu/families.php?superfamily=66]

* 1.A.6 [[Epithelial sodium channel|Epithelial Na⁺ channel family]]

**[[Neurotransmitter]] sodium symporter [http://opm.phar.umich.edu/families.php?superfamily=67]

* 1.A.7 [[P2X purinoreceptor|ATP-gated P2X receptor cation channel family]]

**Ammonia transporters [http://opm.phar.umich.edu/families.php?superfamily=13]

* 1.A.8 [[Major intrinsic protein|Major intrinsic protein superfamily]]

**Drug/Metabolite Transporter (small multidrug resistance transporter EmrE - the structures are retracted as erroneous) [http://opm.phar.umich.edu/families.php?superfamily=77]

* 1.A.9 [[Ligand-gated ion channel|Neurotransmitter receptor, Cys loop, ligand-gated ion channel family]]

* 1.A.10 [[Glutamate-gated ion channel family]] of [[neurotransmitter receptor]]s

'''3. Primary Active Transporters'''

* 1.A.11 [[Ammonia transporter|Ammonium channel transporter family]]

*Light absorption-driven transporters:

* 1.A.12 [[Chloride channel|Intracellular chloride channel family]]

**[[Bacteriorhodopsin]]-like proteins including [[rhodopsin]] (see also [[opsin]])[http://opm.phar.umich.edu/families.php?superfamily=6]

* 1.A.13 [[Chloride channel|Epithelial chloride channel family]]

**Bacterial [[photosynthetic reaction centre]]s and [[photosystem]]s I and II [http://opm.phar.umich.edu/families.php?superfamily=2]

* 1.A.14 [[Testis-enhanced gene transfer family]]

**[[Light harvesting complex]]es from [[bacteria]] and [[chloroplasts]] [http://opm.phar.umich.edu/families.php?superfamily=1]

* 1.A.15 [[Non-selective cation channel-2 family|Nonselective cation channel-2 family]]

*Oxidoreduction-driven transporters

* 1.A.16 [[Formate-nitrite transporter|Formate-nitrite transporter family]]

**Transmembrane cytochrome b-like proteins [http://opm.phar.umich.edu/families.php?superfamily=3]: [[coenzyme Q - cytochrome c reductase]] (cytochrome bc1 ); [[cytochrome b6f complex]]; formate dehydrogenase, respiratory [[nitrate reductase]]; [[succinate - coenzyme Q reductase]] (fumarate reductase); and [[succinate dehydrogenase]]. See [[electron transport chain]].

* 1.A.17 [[Calcium-dependent chloride channel|Calcium-dependent chloride channel family]]

**[[Cytochrome c oxidase]]s [http://opm.phar.umich.edu/families.php?superfamily=4] from [[bacteria]] and [[mitochondria]]

* 1.A.18 [[Tic110 family|Chloroplast envelope anion-channel-forming Tic110 family]]

*Electrochemical potential-driven transporters

* 1.A.19 [[M2 proton channel|Type A influenza virus matrix-2 channel family]]

**Proton or sodium translocating F-type and V-type [[ATPase]]s [http://opm.phar.umich.edu/families.php?superfamily=5]

* 1.A.20 [[BNIP3|BCL2/Adenovirus E1B-interacting protein 3 family]]

*P-P-bond hydrolysis-driven transporters

* 1.A.21 [[Bcl-2 family]]

**P-type [[calcium ATPase]] (five different conformations) [http://opm.phar.umich.edu/families.php?superfamily=22]

* 1.A.22 [[Large-conductance mechanosensitive ion channel]]

**Calcium ATPase regulators [[phospholamban]] and sarcolipin[http://opm.phar.umich.edu/families.php?superfamily=70]

* 1.A.23 [[Small-conductance mechanosensitive ion channel]]

**[[ABC transporter]]s: [http://opm.phar.umich.edu/families.php?superfamily=17 BtuCD], [http://opm.phar.umich.edu/families.php?superfamily=18 multidrug transporter], and [http://opm.phar.umich.edu/families.php?superfamily=198 molybdate uptake transporter]

* 1.A.24 [[Connexin|Gap-junction-forming connexin family]]

**General [[secretory pathway]] (Sec) [[translocon]] (preprotein translocase SecY) [http://opm.phar.umich.edu/families.php?superfamily=19]

* 1.A.25 [[Innexin|Gap-junction-forming innexin family]]

* 1.A.26 [[Magnesium transporter E|Mg²⁺ transporter-E family]]

* 1.A.27 [[Phospholemman|Phospholemman family]]

* 1.A.28 [[Urea transporter family]]

* 1.A.29 [[Urea/amide channel family]]

* 1.A.30 [[H+- or Na+-translocating bacterial MotAB flagellar motor/ExbBD outer-membrane transport energizer superfamily|H⁺- or Na⁺-translocating bacterial MotAB flagellar motor/ExbBD outer-membrane transport energizer superfamily]]

* 1.A.31 [[Annexin|Annexin family]]

* 1.A.32 [[Type B influenza virus NB channel|Type B influenza virus NB channel family]]

* 1.A.33 [[heat-shock protein 70|Cation-channel-forming heat shock protein 70 family]]

* 1.A.34 [[Bacillus gap junction-like channel-forming complex family|''Bacillus'' gap junction-like channel-forming complex family]]

* 1.A.35 [[CorA metal ion transporter|CorA metal ion transporter family]]

* 1.A.36 [[Chloride channel#CLIC family|Intracellular chloride channel family]]

* 1.A.37 [[The CD20 Ca2+ channel family|CD20 Ca²⁺ channel family]]

* 1.A.38 [[The Golgi pH regulator family|Golgi pH regulator family]]

* 1.A.39 [[Type C Influenza Virus CM2 Channel (CM2-C) Family|Type C influenza virus CM2 channel family]]

* 1.A.40 [[Vpu protein|Human immunodeficiency virus type I Vpu channel family]]

* 1.A.41 [[Avian reovirus p10 Vvroporin family]]

* 1.A.42 [[HIV viral protein R family]]

* 1.A.43 [[Camphor resistance or fluoride exporter family]]

* 1.A.44 [[Pore-forming tail Tip pb2 protein of phage T5 family]]

* 1.A.45 [[Phage P22 injectisome family]]

* 1.A.46 [[Anion channel-forming bestrophin family]]

* 1.A.47 [[Nucleotide-sensitive anion-selective channel, ICln family]]

* 1.A.48 [[Anion channel Tweety family]]

* 1.A.49 [[Human coronavirus ns12.9 viroporin family]]

* 1.A.50 [[phospholamban|Phospholamban (Ca²⁺-channel and Ca²⁺-ATPase regulator) family]]

*1.A.51 The Voltage-gated Proton Channel (VPC) Family

*1.A.52 The Ca²⁺ Release-activated Ca²⁺ (CRAC) Channel (CRAC-C) Family

*1.A.53 The Hepatitis C Virus P7 Viroporin Cation-selective Channel (HCV-P7) Family

*1.A.54 The Presenilin ER Ca²⁺ Leak Channel (Presenilin) Family

*1.A.55 The Synaptic Vesicle-Associated Ca²⁺ Channel, Flower (Flower) Family

*1.A.56 The Copper Transporter (Ctr) Family

*1.A.57 The Human SARS Coronavirus Viroporin (SARS-VP)

*1.A.58 The Type B Influenza Virus Matrix Protein 2 (BM2-C) Family

*1.A.59 The Bursal Disease Virus Pore-Forming Peptide, Pep46 (Pep46) Family

*1.A.60 The Mammalian Reovirus Pre-forming Peptide, Mu-1 (Mu-1) Family

*1.A.61 The Insect Nodavirus Channel-forming Chain F (Gamma-Peptide) Family

*1.A.62 The Homotrimeric Cation Channel (TRIC) Family

*1.A.63 The Ignicoccus Outer Membrane α-helical Porin (I-OMP Family

*1.A.64 The Plasmolipin (Plasmolipin) Family

*1.A.65 The Coronavirus Viroporin E Protein (Viroporin E) Family

*1.A.66 The Pardaxin (Pardaxin) Family

*1.A.67 The Membrane Mg²⁺ Transporter (MMgT) Family

*1.A.68 The Viral Small Hydrophobic Viroporin (V-SH) Family

*1.A.69 The Heteromeric Odorant Receptor Channel (HORC) Family

*1.A.70 The Molecule Against Microbes A (MamA) Family

*1.A.71 The Brain Acid-soluble Protein Channel (BASP1 Channel) Family

*1.A.72 The Mer Superfamily

*1.A.73 The Colicin Lysis Protein (CLP) Family

*1.A.74 The Mitsugumin 23 (MG23) Family

*1.A.75 The Mechanical Nociceptor, Piezo (Piezo) Family

*1.A.76 The Magnesium Transporter1 (MagT1) Family

*1.A.77 The Mg²⁺/Ca²⁺ Uniporter (MCU) Family

*1.A.78 The K⁺-selective Channel in Endosomes and Lysosomes (KEL) Family

*1.A.79 The Cholesterol Uptake Protein (ChUP) or Double Stranded RNA Uptake Family

*1.A.80 The NS4a Viroporin (NS4a) Family

*1.A.81 The Low Affinity Ca²⁺ Channel (LACC) Family

*1.A.82 The Hair Cell Mechanotransduction Channel (HCMC) Family

*1.A.83 The SV40 Virus Viroporin VP2 (SV40 VP2) Family

*1.A.84 The Calcium Homeostasis Modulator Ca²⁺ Channel (CALHM-C) Family

*1.A.85 The Poliovirus 2B Viroporin (2B Viroporin) Family

*1.A.86 The Human Papilloma Virus type 16 (HPV16) L2 Viroporin (L2 Viroporin) Family

*1.A.87 The Mechanosensitive Calcium Channel (MCA) Family

*1.A.88 The Fungal Potassium Channel (F-Kch) Family

*1.A.89 The Human Coronavirus 229E Viroporin (229E Viroporin) Family

*1.A.90 The Human Metapneumovirus (HMPV) Viroporin (HMPV-Viroporin) Family

*1.A.91 The Cytoadherence-linked Asexual Protein 3.2 of Plasmodium falciparum (Clag3) Family

*1.A.92 The Reovirus Viroporin VP10 (RVP10) Family

*1.A.93 The Bluetongue Virus Non-Structural Protein 3 Viroporin (NS3) Family

*1.A.94 The Rotavirus Non-structural Glycoprotein 4 Viroporin (NSP4) Family

*1.A.95 The Ephemerovirus Viroporin (EVVP) Family

*1.A.96 The Human Polyoma Virus Viroporin (PVVP) Family

*1.A.97 The Human Papillomavirus type 16 E5 Viroporin (HPV-E5) Family

*1.A.98 Human T-Lymphotropic Virus 1 P13 protein (HTLV1-P13) Family

*1.A.99 The Infectious Bronchitis Virus Envelope Small Membrane Protein E (IBV-E) Family

*1.A.100 The Rhabdoviridae Putative Viroporin, U5 (RV-U5) Family

*1.A.101 The Peroxisomal Pore-forming Pex11 (Pex11) Family

*1.A.102 Influenza A viroporin PB1-F2 (PB1-F2) Family

*1.A.103 The Simian Virus 5 (Parainfluenza Virus 5) SH (SV5-SH) Family

*1.A.104 The Proposed Flagellar Biosynthesis Na⁺ Channel, FlaH (FlaH) Family

*1.A.105 The Mixed Lineage Kinase Domain-like (MLKL) Family

*1.A.106 The Calcium Load-activated Calcium Channel (CLAC) Family

*1.A.107 The Pore-forming Globin (Globin) Family

====1.B. [[Porin (protein)|β-Barrel porins]] and other outer membrane proteins====

'''4. Group Translocators'''

* 1.B.1 [[General bacterial porin family]]

* 1.B.2 [[Chlamydia (bacterium)|Chlamydial]] porin (CP) family

* 1.B.3 [[Maltoporin|Sugar porin]] (SP) family

* 1.B.4 [[Brucella-Rhizobium porin]] (BRP) family

* 1.B.5 [[Pseudomonas]] OprP porin (POP) family

* 1.B.6 [[OmpA-like transmembrane ___domain|OmpA-OmpF porin (OOP) family]]

* 1.B.7 Rhodobacter PorCa porin (RPP) family

* 1.B.8 [[Voltage-dependent anion channel|Mitochondrial and plastid porin (MPP) family]]

* 1.B.9 [[FadL outer membrane protein transport family|FadL outer membrane protein (FadL) family]]

* 1.B.10 [[Nucleoside-specific porin|Nucleoside-specific channel-forming outer membrane porin (Tsx) family]]

* 1.B.11 Outer membrane fimbrial usher porin (FUP) family

* 1.B.12 [[Autotransporter ___domain|Autotransporter-1]] (AT-1) family

* 1.B.13 [[Alginate export porin]] (AEP) family

* 1.B.14 [[Outer Membrane Receptor|Outer membrane receptor (OMR) family]]

* 1.B.15 Raffinose porin (RafY) family

* 1.B.16 Short chain amide and urea porin (SAP) family

* 1.B.17 [[Outer membrane efflux proteins|Outer membrane factor (OMF) family]]

* 1.B.18 [[Outer membrane polysaccharide transporter|Outer membrane auxiliary (OMA) protein family]]

* 1.B.19 Glucose-selective OprB porin (OprB) family

* 1.B.20 Two-partner secretion (TPS) family

* 1.B.21 [[Outer membrane protein G|OmpG porin (OmpG) family]]

* 1.B.22 Outer bacterial membrane secretin (secretin) family

* 1.B.23 Cyanobacterial porin (CBP) family

* 1.B.24 [[Mycobacterial porin]]

* 1.B.25 [[Outer membrane porin D|Outer membrane porin (Opr) family]]

* 1.B.26 Cyclodextrin porin (CDP) family

* 1.B.31 [[Campylobacter jejuni]] major outer membrane porin (MomP) family

* 1.B.32 Fusobacterial outer membrane porin (FomP) family

* 1.B.33 Outer membrane protein insertion porin (Bam complex) (OmpIP) family

* 1.B.34 [[Corynebacterial porin B|Corynebacterial porins]]

* 1.B.35 [[Oligogalacturonate-specific porin|Oligogalacturonate-specific porin (KdgM) family]]

* 1.B.39 [[Outer membrane protein W family|Bacterial porin, OmpW (OmpW) family]]

* 1.B.42 Outer membrane lipopolysaccharide export porin (LPS-EP) family

* 1.B.43 Coxiella porin P1 (CPP1) family

* 1.B.44 Probable protein translocating porphyromonas gingivalis porin (PorT) family

* 1.B.49 Anaplasma P44 (A-P44) porin family

* 1.B.48 Curli-like transporters

* 1.B.54 [[Intimin]]/Invasin (Int/Inv) or [[Autotransporter ___domain|Autotransporter-3]] family

* 1.B.55 Poly-acetyl-D-glucosamine porin (PgaA) family

* 1.B.57 Legionella major-outer membrane protein (LM-OMP) family

* 1.B.60 Omp50 porin (Omp50 Porin) family

* 1.B.61 Delta-proteobacterial porin (Delta-porin) family

* 1.B.62 Putative bacterial porin (PBP) family

* 1.B.66 Putative beta-barrel porin-2 (BBP2) family

* 1.B.67 Putative beta barrel porin-4 (BBP4) family

* 1.B.68 Putative beta barrel porin-5 (BBP5) superfamily

* 1.B.70 Outer membrane channel (OMC) family

* 1.B.71 Proteobacterial/verrucomicrobial porin (PVP) family

* 1.B.72 Protochlamydial outer membrane porin (PomS/T) family

* 1.B.73 Capsule biogenesis/assembly (CBA) family

* 1.B.78 DUF3374 electron transport-associated porin (ETPorin) family

====1.C [[Pore-forming toxin]]s (proteins and peptides)====

'''5. Transport Electron Carriers'''

* 1.C.3 α-[[Hemolysin]] (αHL) family

**Disulfide bond formation protein B (DsbB) [http://opm.phar.umich.edu/protein.php?search=2hi7]

* 1.C.4 [[Aerolysin]] family

'''8. Accessory Factors Involved in Transport'''

* 1.C.5 [[ε-toxin]] family

* 1.C.11 [[RTX toxin|RTX-toxin superfamily]]

* 1.C.12 [[MACPF|Membrane attack complex/perforin superfamily]]

* 1.C.13 [[Leukocidin]] family

* 1.C.14 [[Cytohemolysin]] (CHL) family

* 1.C.39 [[Cholesterol-dependent cytolysin|Thiol-activated cholesterol-dependent cytolysin family]]

* 1.C.43 [[Lysenin]] family

* 1.C.56 [[HrpZ Family|''Pseudomonas syringae'' HrpZ cation channel family]]

* 1.C.57 [[Clostridial Cytotoxin family|Clostridial cytotoxin family]]

*1.C.58 [[Microcin|The Microcin E492/C24 (Microcin E492) Family]]

* 1.C.74 [[Snake venom|Snake cytotoxin]] (SCT) family

* 1.C.97 [[Pleurotolysin|Pleurotolysin pore-forming family]]

====1.D Non-ribosomally synthesized channels====

'''9. Incompletely Characterized Transport Systems'''

* 1.D.1 The [[Gramicidin A]] Channel Family

* 1.D.2 The Channel-forming [[Syringomycin E|Syringomycin]] Family

* 1.D.3 The Channel-Forming Syringopeptin Family

* 1.D.4 The Tolaasin Channel-forming Family

* 1.D.5 The [[Alamethicin]] or [[Peptaibol]] Antibiotic Channel-forming Family

* 1.D.6 The Complexed Poly 3-Hydroxybutyrate Ca²⁺ Channel (cPHB-CC) Family

* 1.D.7 The Beticolin Family

* 1.D.8 The [[Saponin]] Family

* 1.D.9 The [[Polyglutamine]] Ion Channel (PG-IC) Family

* 1.D.10 The [[Ceramide]]-forming Channel Family

* 1.D.11 The [[Surfactin]] Family

* 1.D.12 The Beauvericin (Beauvericin) Family

* 1.D.13 DNA-delivery Amphipathic Peptide Antibiotics (DAPA)

* 1.D.14 The Synthetic Leu/Ser Amphipathic Channel-forming Peptide (l/S-SCP) Family

* 1.D.15 [[Daptomycin|The Daptomycin (Daptomycin) Family]]

* 1.D.16 The Synthetic Amphipathic Pore-forming Heptapeptide (SAPH) Family

* 1.D.17 Combinatorially-designed, Pore-forming, β-sheet Peptide Family

* 1.D.18 The Pore-forming Guanosine-Bile Acid Conjugate Family

* 1.D.19 Ca²⁺ Channel-forming Drug, [[Digitoxin]] Family

* 1.D.20 The Pore-forming Polyene Macrolide Antibiotic/fungal Agent (PMAA) Family

* 1.D.21 The Lipid Nanopore (LipNP) Family

* 1.D.22 The Proton-Translocating Carotenoid Pigment, [[Zeaxanthin]] Family

* 1.D.23 Phenylene Ethynylene Pore-forming Antimicrobial (PEPA) Family

* 1.D.24 The Marine Sponge Polytheonamide B (pTB) Family

* 1.D.25 The Arylamine Foldamer (AAF) Family

* 1.D.26 The Dihydrodehydrodiconiferyl alcohol 9'-O-β-D-glucoside (DDDC9G) Family

* 1.D.27 The Thiourea isosteres Family

* 1.D.28 The Lipopeptaibol Family

* 1.D.29 The Macrocyclic Oligocholate Family

* 1.D.30 The Artificial Hydrazide-appended pillar[5]arene Channels (HAPA-C) Family

* 1.D.31 The [[Amphotericin B]] Family

* 1.D.32 The Pore-forming [[Novicidin]] Family

* 1.D.33 The Channel-forming [[Polytheonamide B]] Family

* 1.D.34 The Channel-forming Oligoester Bolaamphiphiles

* 1.D.35 The Pore-forming cyclic [[Lipodepsipeptide]] Family

* 1.D.36 The [[Oligobornene]] Ion Channel Family

* 1.D.37 The [[Hibicuslide C]] Family

* 1.D.38 The Cyclic Peptide Nanotube (cPepNT) Family

* 1.D.39 The Light-controlled Azobenzene-based Amphiphilic Molecular Ion Channel (AAM-IC) Family

* 1.D.40 The Protein-induced Lipid Toroidal Pore Family

* 1.D.41 The Sprotetonate-type Ionophore (Spirohexanolide) Family

* 1.D.42 The Phe-Arg Tripeptide-Pillar[5]Arene Channel (TPPA-C) Family

* 1.D.43 The Triazole-tailored Guanosine Dinucleoside Channel (TT-GDN-C) Family

* 1.D.44 The Synthetic Ion Channel with Redox-active Ferrocene (ICRF) Family

* 1.D.45 The Sonoporation and Electroporation Membrane Pore (SEMP) Family

* 1.D.46 The DNA Nanopore (DnaNP) Family

* 1.D.47 The Pore-forming Synthetic Cyclic Peptide (PSCP) Family

* 1.D.48 The Pore-forming [[Syringomycin E]] Family

* 1.D.49 The Transmembrane Carotenoid Radical Channel (CRC) Family

* 1.D.50 The Amphiphilic bis-Catechol Anion Transporter (AC-AT) Family

* 1.D.51 The Protein Nanopore (ProNP) Family

* 1.D.52 The Aromatic Oligoamide Macrocycle Nanopore (OmnNP) Family

* 1.D.53 The alpha, gamma-Peptide Nanotube (a,gPepNT) Family

* 1.D.54 The potassium-selective Hexyl-Benzoureido-15-Crown-5-Ether Ion Channel (HBEC) Family

* 1.D.55 The Porphyrin-based Nanopore (PorNP) Family

* 1.D.56 The Alpha-Aminoisobutyrate (Aib) Oligomeric Nanopore (AibNP) Family

* 1.D.57 The Lipid Electro-Pore (LEP) Family

* 1.D.58 The Anion Transporting Prodigiosene (Prodigiosene) Family

* 1.D.59 The Anion Transporting Perenosin (Perenosin) Family

* 1.D.60 The Alpha,Gamma-Cyclic Peptide (AGCP) Family

* 1.D.61 The Anionophoric {{Chem name|2,6-Bis(Benzimidazol-2-yl)Pyridine}} (ABBP) Family

* 1.D.62 The Bis-Triazolyl DiGuanosine Derivative Channel-forming (TDG) Family

* 1.D.63 The Peptide-based Nanopore (PepNP) Family

* 1.D.64 The Carbon Nanotube (CarNT) Family

* 1.D.65 The Pore-forming Amphidinol (Amphidinol) Family

* 1.D.66 The Helical Macromolecule Nanopore (HmmNP) Family

* 1.D.67 The Crown Ether-modified Helical Peptide Ion Channel (CEHP) Family

* 1.D.68 The Pore-forming Pleuronic Block Polymer (PPBP) Family

* 1.D.69 The Conical Nanopore (ConNP) Family

* 1.D.70 The Metallic (Au/Ag/Pt/graphene) Nanopore (MetNP) Family

* 1.D.71 The Synthetic TP359 Peptide (TP359) Family

* 1.D.72 The Chloride Carrier Triazine-based Tripodal Receptor (CCTTR) Family

* 1.D.73 The Mesoporous Silica Nanopore (SilNP) Family

* 1.D.74 The Stimulus-responsive Synthetic Rigid p-Octiphenyl Stave Pore (SSROP) Family

====1.E [[Holin]]s====

==Examples==

{{main|Holins}}

* [[Cystic fibrosis transmembrane conductance regulator]] -- 3.A.1.202.1

====1.F [[Vesicle fusion]] pores====

==See also==

* 1.F.1 The Synaptosomal Vesicle Fusion Pore (SVF-Pore) Family

* [[List of proteins]]

* 1.F.2 The Octameric Exocyst (Exocyst) Family

====1.G [[Viral protein#Viral envelope|Viral fusion]] pores====

* 1.G.1 The Viral Pore-forming Membrane Fusion Protein-1 (VMFP1) Family

* 1.G.2 The Viral Pore-forming Membrane Fusion Protein-2 (VMFP2) Family

* 1.G.3 The Viral Pore-forming Membrane Fusion Protein-3 (VMFP3) Family

* 1.G.4 The Viral Pore-forming Membrane Fusion Protein-4 (VMFP4) Family

* 1.G.5 The Viral Pore-forming Membrane Fusion Protein-5 (VMFP5) Family

* 1.G.6 The Hepadnaviral S Fusion Protein (HBV-S Protein) Family

* 1.G.7 The Reovirus FAST Fusion Protein (R-FAST) Family

* 1.G.8 The Arenavirus Fusion Protein (AV-FP) Family

* 1.G.9 The Syncytin (Syncytin) Family

* 1.G.10 The Herpes Simplex Virus Membrane Fusion Complex (HSV-MFC) Family

* 1.G.11 Poxvirus Cell Entry Protein Complex (PEP-C) Family

* 1.G.12 The Avian Leukosis Virus gp95 Fusion Protein (ALV-gp95) Family

* 1.G.13 The Orthoreovirus Fusion-associated Small Transmembrane (FAST) Family

* 1.G.14 The Influenza Virus Hemagglutinin/Fusion Pore-forming Protein (Influenza-H/FPP) Family

* 1.G.15 The Autographa californica Nuclear Polyhedrosis Virus Major Envelope Glycoprotein GP64 (GP64) Family

* 1.G.16 The Human Immunodeficiency Virus Type 1 (HIV-1) Fusion Peptide (HIV-FP) Family

* 1.G.17 The Bovine Leukemia Virus Envelop Glycoprotein (BLV-Env) Family

* 1.G.18 The SARS-CoV Fusion Peptide in the Spike Glycoprotein Precursor (SARS-FP) Family

* 1.G.19 The Rotavirus Pore-forming Membrane Fusion Complex (Rotavirus MFC) Family

* 1.G.20 The Hantavirus Gc Envelope Fusion Glycoprotein (Gc-EFG) Family

* 1.G.21 The Epstein Barr Virus (Human Herpes Virus 4) Gp42 (Gp42) Family

* 1.G.22 The Cytomegalovirus (Human Herpesvirus 5) Glycoprotein gO (gO) Family

====1.H [[Paracellular channel]]s====

* 1.H.1 The [[Claudin]] Tight Junction (Claudin1) Family

* 1.H.2 The Invertebrate PMP22-Claudin (Claudin2) Family

====1.I [[Membrane-bound channel]]s====

* 1.I.1 [[Nuclear pore complex]] family, including [[karyopherin]]s

* 1.I.2 Plant [[plasmodesmata]] family

===2. Electrochemical potential-driven transporters===

====2.A Porters ([[uniporter]]s, [[symporter]]s, [[antiporter]]s)====

{{see also|Amino acid transporter}}

*2.A.1 [[Major facilitator superfamily|Major Facilitator superfamily]] (MFS), see also [[Lactose permease]], [[Phosphate permease]] and [[Glucose transporter]]

*2.A.2 [[Glycoside-pentoside-hexuronide:cation symporter family|The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family]]

*2.A.3 [[APC superfamily|The Amino Acid-Polyamine-Organocation (APC) Family]]

*2.A.4 [[Cation diffusion facilitator]] (CDF) Family

*2.A.5 [[Ferroportin|Zinc (Zn²⁺)-Iron (Fe²⁺) Permease]] Family

*2.A.6 [[Resistance-nodulation-cell division superfamily|Resistance-Nodulation-Cell Division Superfamily]], see also [[SecDF protein-export membrane protein]]

*2.A.7 The [[Small multidrug resistance protein|Drug/Metabolite Transporter]] (DMT) Superfamily

*2.A.8 The Gluconate:H⁺ Symporter (GntP) Family

*2.A.9 The Membrane Protein Insertase (YidC/Alb3/Oxa1) Family

*2.A.10 The 2-Keto-3-Deoxygluconate Transporter (KdgT) Family

*2.A.11 The Citrate-Mg²⁺:H⁺ (CitM) Citrate-Ca²⁺:H⁺ (CitH) Symporter (CitMHS) Family

*2.A.12 [[ATP:ADP antiporter family|ATP:ADP Antiporter Family]]

*2.A.13 The C4-Dicarboxylate Uptake (Dcu) Family

*2.A.14 [[Lactate permease family|Lactate Permease Family]]

*2.A.15 [[Betaine transporter|The Betaine/Carnitine/Choline Transporter (BCCT) Family]]

*2.A.16 [[Tellurite-resistance/dicarboxylate transporter|Tellurite-resistance/Dicarboxylate Transporter]] Family

*2.A.17 [[Proton-dependent oligopeptide transporter|Proton-dependent Oligopeptide Transporter Family]]

*2.A.18 The Amino Acid/Auxin Permease (AAAP) Family

*2.A.19 The Ca²⁺:Cation Antiporter (CaCA) Family

*2.A.20 The Inorganic Phosphate Transporter (PiT) Family

*2.A.21 [[Sodium-solute symporter|Solute:Sodium Symporter Family]]

*2.A.22 The [[Neurotransmitter sodium symporter|Neurotransmitter:Sodium Symporter]] Family

*2.A.23 The Dicarboxylate/Amino Acid:Cation (Na⁺ or H⁺) Symporter (DAACS) Family

*2.A.24 The 2-Hydroxycarboxylate Transporter (2-HCT) Family

*2.A.25 [[AGCS family|Alanine or Glycine:Cation Symporter]] (AGCS) Family

*2.A.26 The Branched Chain Amino Acid:Cation Symporter (LIVCS) Family

*2.A.27 The Glutamate:Na⁺ Symporter (ESS) Family

*2.A.28 [[Bile acid:sodium symporter|Bile Acid:Na⁺ Symporter]] Family

*2.A.29 [[Mitochondrial carrier]] Family

*2.A.30 [[Chloride potassium symporter|Cation-Chloride Cotransporter]] (CCC) Family

*2.A.31 [[Anion exchanger family|Anion Exchanger Family]]

*2.A.32 The Silicon Transporter (Sit) Family

*2.A.33 [[Sodium-proton antiporter|NhaA Na⁺:H⁺ Antiporter]] (NhaA) Family

*2.A.34 The NhaB Na⁺:H⁺ Antiporter (NhaB) Family

*2.A.35 The NhaC Na⁺:H⁺ Antiporter (NhaC) Family

*2.A.36 [[Monovalent cation:proton antiporter-1|Monovalent Cation:Proton Antiporter-1]] (CPA1) Family

*2.A.37 [[Monovalent cation:proton antiporter-2|Monovalent Cation:Proton Antiporter-2]] (CPA2) Family

*2.A.38 [[Potassium transporter family|K⁺ Transporter (Trk)]] Family

*2.A.39 [[Nucleobase cation symporter-1|Nucleobase:Cation Symporter-1]] (NCS1) Family

*2.A.40 [[Nucleobase cation symporter-2|Nucleobase:Cation Symporter-2]] (NCS2) Family

*2.A.41 The Concentrative Nucleoside Transporter (CNT) Family

*2.A.42 The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family

*2.A.43 The Lysosomal Cystine Transporter (LCT) Family

*2.A.45 [[Arsenite-antimonite transporter|Arsenite-Antimonite Efflux Family]]

*2.A.46 The Benzoate:H⁺ Symporter (BenE) Family

*2.A.47 [[Divalent anion–sodium symporter|Divalent Anion:Na⁺ Symporter]] (DASS) Family

*2.A.48 The Reduced Folate Carrier (RFC) Family

*2.A.49 [[Chloride channel|Chloride Carrier/Channel]] (ClC) Family

*2.A.50 The Glycerol Uptake (GUP) Family

*2.A.51 The Chromate Ion Transporter (CHR) Family

*2.A.52 The Ni²⁺-Co²⁺ Transporter (NiCoT) Family

*2.A.53 [[Sulfate permease]] (SulP) Family

*2.A.54 The Mitochondrial Tricarboxylate Carrier (MTC) Family

*2.A.55 [[Natural Resistance-Associated Macrophage Proteins|The Metal Ion (Mn²⁺-iron) Transporter]] (Nramp) Family

*2.A.56 The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family

*2.A.57 The Equilibrative Nucleoside Transporter (ENT) Family

*2.A.58 The Phosphate:Na⁺ Symporter (PNaS) Family

*2.A.59 The Arsenical Resistance-3 (ACR3) Family

*2.A.60 [[Organo anion transporter family|Organo Anion Transporter]] (OAT) Family

*2.A.61 The C4-dicarboxylate Uptake C (DcuC) Family

*2.A.62 The NhaD Na⁺:H⁺ Antiporter (NhaD) Family

*2.A.63 [[Monovalent cation:proton antiporter-3|The Monovalent Cation (K⁺ or Na⁺):Proton Antiporter-3]] (CPA3) Family

*2.A.64 [[Twin-arginine translocation pathway|Twin Arginine Targeting (Tat) Family]]

*2.A.65 The Bilirubin Transporter (BRT) Family

*2.A.66 The Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily

*2.A.67 The Oligopeptide Transporter (OPT) Family

*2.A.68 The p-Aminobenzoyl-glutamate Transporter (AbgT) Family

*2.A.69 The Auxin Efflux Carrier (AEC) Family

*2.A.70 The Malonate:Na⁺ Symporter (MSS) Family

*2.A.71 The Folate-Biopterin Transporter (FBT) Family

*2.A.72 The K⁺ Uptake Permease (KUP) Family

*2.A.73 The Short Chain Fatty Acid Uptake (AtoE) Family

*2.A.74 The 4 TMS Multidrug Endosomal Transporter (MET) Family

*2.A.75 The L-Lysine Exporter (LysE) Family

*2.A.76 The Resistance to Homoserine/Threonine (RhtB) Family

*2.A.77 The Cadmium Resistance (CadD) Family

*2.A.78 The Branched Chain Amino Acid Exporter (LIV-E) Family

*2.A.79 The Threonine/Serine Exporter (ThrE) Family

*2.A.80 The Tricarboxylate Transporter (TTT) Family

*2.A.81 The Aspartate:Alanine Exchanger (AAEx) Family

*2.A.82 The Organic Solute Transporter (OST) Family

*2.A.83 The Na⁺-dependent Bicarbonate Transporter (SBT) Family

*2.A.84 The Chloroplast Maltose Exporter (MEX) Family

*2.A.85 The Aromatic Acid Exporter (ArAE) Family

*2.A.86 The Autoinducer-2 Exporter (AI-2E) Family (Formerly the PerM Family, TC #9.B.22)

*2.A.87 The Prokaryotic Riboflavin Transporter (P-RFT) Family

*2.A.88 Vitamin Uptake Transporter (VUT or ECF) Family

*2.A.89 The Vacuolar Iron Transporter (VIT) Family

*2.A.90 [[Vitamin A receptor|Vitamin A Receptor/Transporter]] (STRA6) Family

*2.A.91 Mitochondrial tRNA Import Complex (M-RIC) (Formerly 9.C.8)

*2.A.92 The Choline Transporter-like (CTL) Family

*2.A.94 The Phosphate Permease (Pho1) Family

*2.A.95 The 6TMS Neutral Amino Acid Transporter (NAAT) Family

*2.A.96 The Acetate Uptake Transporter (AceTr) Family

*2.A.97 The Mitochondrial Inner Membrane K⁺/H⁺ and Ca²⁺/H⁺ Exchanger (LetM1) Family

*2.A.98 The Putative Sulfate Exporter (PSE) Family

*2.A.99 The 6TMS Ni²⁺ uptake transporter (HupE-UreJ) Family

*2.A.100 The Ferroportin (Fpn) Family

*2.A.101 The Malonate Uptake (MatC) Family (Formerly UIT1)

*2.A.102 The 4-Toluene Sulfonate Uptake Permease (TSUP) Family

*2.A.103 The Bacterial Murein Precursor Exporter (MPE) Family

*2.A.104 The L-Alanine Exporter (AlaE) Family

*2.A.105 The Mitochondrial Pyruvate Carrier (MPC) Family

*2.A.106 The Ca²⁺:H⁺ Antiporter-2 (CaCA2) Family

*2.A.107 The MntP Mn²⁺ Exporter (MntP) Family

*2.A.108 The Iron/Lead Transporter (ILT) Family

*2.A.109 The Tellurium Ion Resistance (TerC) Family

*2.A.110 The Heme Transporter, heme-responsive gene protein (HRG) Family

*2.A.111 The Na⁺/H⁺ Antiporter-E (NhaE) Family

*2.A.112 The KX Blood-group Antigen (KXA) Family

*2.A.113 The Nickel/cobalt Transporter (NicO) Family

*2.A.114 The Putative Peptide Transporter Carbon Starvation CstA (CstA) Family

*2.A.115 The Novobiocin Exporter (NbcE) Family

*2.A.116 The Peptidoglycolipid Addressing Protein (GAP) Family

*2.A.117 The Chlorhexadine Exporter (CHX) family

*2.A.118 The Basic Amino Acid Antiporter (ArcD) Family

*2.A.119 The Organo-Arsenical Exporter (ArsP) Family

*2.A.120 The Putative Amino Acid Permease (PAAP) Family

*2.A.121 The Sulfate Transporter (CysZ) Family

*2.A.122 The LrgB/CidB holin-like auxiliary protein (LrgB/CidB) Family

*2.A.123 The Sweet; PQ-loop; Saliva; MtN3 (Sweet) Family

*2.A.124 The Lysine Exporter (LysO) Family

*2.A.125 The Eukaryotic Riboflavin Transporter (E-RFT) Family

*2.A.126 The Fatty Acid Exporter (FAX) Family

*2.A.127 Enterobacterial Cardiolipin Transporter (CLT) Family

====2.B Nonribosomally synthesized porters====

*2.B.1 The [[Valinomycin]] Carrier Family

*2.B.2 The [[Monensin]] Family

*2.B.3 The [[Nigericin]] Family

*2.B.4 The [[Macrotetrolide]] Antibiotic (MA) Family

*2.B.5 The Macrocyclic Polyether (MP) Family

*2.B.6 The [[Ionomycin]] Family

*2.B.7 The Transmembrane α-helical Peptide Phospholipid Translocation (TMP-PLT) Family

*2.B.8 The [[Bafilomycin]] A1 (Bafilomycin) Family

*2.B.9 The [[Cell Penetrating Peptide]] (CPP) Functional Family

*2.B.10 The Synthetic CPP, [[Transportan]] Family

*2.B.11 The [[Calcimycin]] or A23187 Carrier-type Ionophore Family

*2.B.12 The [[Salinomycin]] Family

*2.B.13 The Tetrapyrrolic Macrocyclic Anion Antiporter (TPMC-AA) Family

*2.B.14 The Lasalocid A or X-537A Ionophore (Lasalocid) Family

*2.B.15 The Tris-thiourea Tripodal-based Chloride Carrier (TTT-CC) Family

*2.B.16 The Halogen-bond-containing Compound Anion Carrier (HCAC) Family

*2.B.17 The Isophthalaminde Derivative H⁺:Cl⁻ Co-transporter (IDC) Family

*2.B.18 The Pyridine-2,6-Dicarboxamine Derivative (PDCA) H+:Cl⁻ Co-transporter Family

*2.B.19 The Calix(4)pyrrole Derivative (C4P) Family

*2.B.20 The Prodigiosin (Prodigiosin) Chloride/Bicarbonate Exchanger Family

*2.B.21 The ortho-Phenylenediamine-bis-Urea Derivative Anion Transporter (oPDA-U) Family

*2.B.22 The Imidazolium-functionalized Anion Transporter (IAT) Family

*2.B.23 The Homotetrameric Transmembrane Zn²⁺/Co²⁺:Proton Synthetic Antiporter, Rocker (Rocker) Family

*2.B.24 The {{Chem name|2,6-Bis(benzimidazol-2-yl)pyridine}} Anion Carrier (BBP-AC) Family

*2.B.25 The Peptide-mediated Lipid Flip-Flop (PLFF) Family

*2.B.26 The {{Not a typo|Bis(imidazolyl)-functionalized}} {{Not a typo|Bis(Choloyl)}} Conjugate (BIBCC) Family

*2.B.27 The Tris-Urea Anion Transporter Family

*2.B.29 The Anionophoric Marine Alkaloid [[Tambjamine]] Family

====2.C Ion-gradient-driven energizers====

*2.C.1 The TonB-ExbB-ExbD/TolA-TolQ-TolR (TonB) Family of Auxiliary Proteins for Energization of Outer Membrane Receptor (OMR)-mediated Active Transport

===3. [[Primary active transport]]ers===

====3.A. P-P-bond hydrolysis-driven transporters====

*3.A.1 [[ABC transporter]]s including BtuCD, molybdate uptake transporter, [[Cystic fibrosis transmembrane conductance regulator]] and others

*3.A.2 The H⁺- or Na⁺-translocating [[F-type ATPase]], [[V-type ATPase]] and A-type ATPase superfamily

*3.A.3 [[P-type ATPase|The P-type ATPase]] Superfamily

*3.A.4 [[ArsB and ArsAB transporters|The Arsenite-Antimonite efflux]] family

*3.A.5 [[SecY protein|General secretory pathway]] (Sec) [[translocon]] (preprotein translocase SecY)

*3.A.6 The Type III (Virulence-related) Secretory Pathway (IIISP) Family

*3.A.7 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family

*3.A.8 The Mitochondrial Protein Translocase (MPT) Family

*3.A.9 The Chloroplast Envelope Protein Translocase (CEPT or Tic-Toc) Family

*3.A.10 [[H+, Na+-translocating pyrophosphatase family|H⁺, Na⁺-translocating Pyrophosphatase]] family

*3.A.11 The Bacterial Competence-related DNA Transformation Transporter (DNA-T) Family

*3.A.12 The Septal DNA Translocator (S-DNA-T) Family

*3.A.13 The Filamentous Phage Exporter (FPhE) Family

*3.A.14 The Fimbrilin/Protein Exporter (FPE) Family

*3.A.15 The Outer Membrane Protein Secreting Main Terminal Branch (MTB) Family

*3.A.16 The Endoplasmic Reticular Retrotranslocon (ER-RT) Family

*3.A.17 The Phage T7 Injectisome (T7 Injectisome) Family

*3.A.18 The Nuclear mRNA Exporter (mRNA-E) Family

*3.A.19 The TMS Recognition/Insertion Complex (TRC) Family

*3.A.20 The Peroxisomal Protein Importer (PPI) Family

*3.A.21 The C-terminal Tail-Anchored Membrane Protein Biogenesis/ Insertion Complex (TAMP-B) Family

*3.A.22 The Transcription-coupled TREX/TAP Nuclear mRNA Export Complex (TREX) Family

*3.A.23 The Type VI Symbiosis/Virulence Secretory Pathway (VISP) Family

*3.A.24 Type VII or ESX Protein Secretion System (T7SS) Family

*3.A.25 The Symbiont-specific ERAD-like Machinery (SELMA) Family

*3.A.26 The Plasmodium Translocon of Exported proteins (PTEX) Family

====3.B Decarboxylation-driven transporters====

*3.B.1 The Na⁺-transporting Carboxylic Acid Decarboxylase (NaT-DC) Family

====3.C Methyltransfer-driven transporters====

*3.C.1 The Na⁺ Transporting Methyltetrahydromethanopterin:Coenzyme M Methyltransferase (NaT-MMM) Family

====3.D. Oxidoreduction-driven transporters====

They include a number of transmembrane [[cytochrome b]]-like proteins including [[coenzyme Q - cytochrome c reductase]] (cytochrome bc1 ); [[cytochrome b6f complex]]; formate dehydrogenase, respiratory [[nitrate reductase]]; [[succinate - coenzyme Q reductase]] (fumarate reductase); and [[succinate dehydrogenase]]. See [[electron transport chain]].

*3.D.1 [[NADH:ubiquinone reductase (H+-translocating)|The H⁺ or Na⁺-translocating NADH Dehydrogenase]] ("complex I") family

*3.D.2 The Proton-translocating Transhydrogenase (PTH) Family

*3.D.3 [[Cytochrome c nitrite reductase|The Proton-translocating Quinol:Cytochrome c Reductase]]) Superfamily

*3.D.4 [[Cytochrome c oxidase|Proton-translocating Cytochrome Oxidase]] (COX) Superfamily

*3.D.5 The Na⁺-translocating NADH:Quinone Dehydrogenase (Na-NDH or NQR) Family

*3.D.6 The Putative Ion (H⁺ or Na⁺)-translocating NADH:Ferredoxin Oxidoreductase (NFO or RNF) Family

*3.D.7 The H₂:Heterodisulfide Oxidoreductase (HHO) Family

*3.D.8 The Na⁺- or H⁺-Pumping Formyl Methanofuran Dehydrogenase (FMF-DH) Family

*3.D.9 The H⁺-translocating F420H2 Dehydrogenase (F420H2DH) Family

*3.D.10 The Prokaryotic Succinate Dehydrogenase (SDH) Family

====3.E. Light absorption-driven transporters====

*[[Bacteriorhodopsin]]-like proteins including [[rhodopsin]] (see also [[opsin]])

*Bacterial [[photosynthetic reaction centre]]s and [[photosystem]]s I and II

*[[Light harvesting complex]]es from [[bacteria]] and [[chloroplasts]]

===4. Group translocators===

====4.A Phosphotransfer-driven group translocators====

{{main|PTS-GFL superfamily}}

*4.A.1 [[The PTS glucose-glucoside (Glc) family|The PTS Glucose-Glucoside (Glc) Family]]

*4.A.2 The PTS Fructose-Mannitol (Fru) Family

*4.A.3 The PTS Lactose-N,N'-Diacetylchitobiose-β-glucoside (Lac) Family

*4.A.4 The PTS Glucitol (Gut) Family

*4.A.5 The PTS Galactitol (Gat) Family

*4.A.6 [[PTS Mannose-Fructose-Sorbose Family|The PTS Mannose-Fructose-Sorbose (Man) Family]]

*4.A.7 The PTS L-Ascorbate (L-Asc) Family

====4.B Nicotinamide ribonucleoside uptake transporters====

*4.B.1 The Nicotinamide Ribonucleoside (NR) Uptake Permease (PnuC) Family

====4.C Acyl CoA ligase-coupled transporters====

*4.C.1 The Proposed Fatty Acid Transporter (FAT) Family

*4.C.2 The Carnitine O-Acyl Transferase (CrAT) Family

*4.C.3 The Acyl-CoA Thioesterase (AcoT) Family

====4.D Polysaccharide Synthase/Exporters====

*4.D.1 The Putative Vectorial Glycosyl Polymerization (VGP) Family

*4.D.2 The Glycosyl Transferase 2 (GT2) Family

*4.D.3 The Glycan Glucosyl Transferase (OpgH) Family

====4.E. Vacuolar Polyphosphate Polymerase-catalyzed Group Translocators====

*4.E.1 The Vacuolar (Acidocalcisome) Polyphosphate Polymerase (V-PPP) Family

===5. Transport electron carriers===

====5.A Transmembrane 2-electron transfer carriers====

*5.A.1 The Disulfide Bond Oxidoreductase D (DsbD) Family

*5.A.2 The Disulfide Bond Oxidoreductase B (DsbB) Family

*5.A.3 The Prokaryotic Molybdopterin-containing Oxidoreductase (PMO) Family

====5.B Transmembrane 1-electron transfer carriers====

*5.B.1 The Phagocyte ([[gp91phox]]) [[NADPH oxidase|NADPH Oxidase]] Family

*5.B.2 The Eukaryotic [[Cytochrome b561]] (Cytb561) Family

*5.B.3 The Geobacter Nanowire Electron Transfer (G-NET) Family

*5.B.4 The Plant Photosystem I Supercomplex (PSI) Family

*5.B.5 The Extracellular Metal Oxido-Reductase (EMOR) Family

*5.B.6 The [[STEAP3|Transmembrane Epithelial Antigen Protein-3]] Ferric Reductase (STEAP) Family

*5.B.7 The [[YedZ family|YedZ (YedZ) Family]]

*5.B.8 The Trans-Outer Membrane Electron Transfer Porin/Cytochrome Complex (ET-PCC) Family

*5.B.9 The Porin-Cytochrome c (Cyc2) Family

===8. Accessory factors involved in transport===

====8.A Auxiliary transport proteins====

====8.B Ribosomally synthesized protein/peptide toxins that target channels and carriers====

====8.C Non-ribosomally synthesized toxins that target channels and carriers====

===9. Incompletely characterized transport systems===

====9.A Recognized transporters of unknown biochemical mechanism====

====9.B Putative transport proteins====

====9.C Functionally characterized transporters lacking identified sequences====

==References==

{{reflist}}

==External links==

* [http://www.tcdb.org/ TransportTransporter Classification Database]

* [http://www.chem.qmul.ac.uk/iubmb/mtp/ List] at qmul.ac.uk

* {{cite journal |vauthors=Saier MH, Tran CV, Barabote RD |title=TCDB: the Transporter Classification Database for membrane transport protein analyses and information |journal=Nucleic Acids Res. |volume=34 |issue=Database issue |pages=D181–6 |date=January 2006 |pmid=16381841 |pmc=1334385 |doi=10.1093/nar/gkj001 |url=}}

* {{cite journal |vauthors=Busch W, Saier MH |title=The transporter classification (TC) system, 2002 |journal=Crit. Rev. Biochem. Mol. Biol. |volume=37 |issue=5 |pages=287–337 |year=2002 |pmid=12449427 |doi= 10.1080/10409230290771528|s2cid=10558982 }}

* [http://www.guidetopharmacology.org/GRAC/ReceptorFamiliesForward?type=TRANSPORTER Classification of human transporters in pharmacology]

{{Ion channels}}

* {{cite journal |author=Saier MH, Tran CV, Barabote RD |title=TCDB: the Transporter Classification Database for membrane transport protein analyses and information |journal=Nucleic Acids Res. |volume=34 |issue=Database issue |pages=D181–6 |year=2006 |month=January |pmid=16381841 |pmc=1334385 |doi=10.1093/nar/gkj001 |url=http://nar.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=16381841}}

{{Pore-forming toxins}}

{{Non-ribosomally synthesized channels}}

* {{cite journal |author=Busch W, Saier MH |title=The transporter classification (TC) system, 2002 |journal=Crit. Rev. Biochem. Mol. Biol. |volume=37 |issue=5 |pages=287–337 |year=2002 |pmid=12449427 |doi= |url=}}

{{Vesicular transport proteins}}

{{Membrane transport proteins}}

{{Nonribosomally synthesized porters}}

{{ABC transporters}}

{{Ion pumps}}

{{Oxidoreduction-driven transporters}}

[[Category:Biochemistry databases]]

[[Category:Transport proteins]]

[[Category:Transmembrane proteins]]

[[Category:ClassificationProtein systemsclassification]]

[[Category:Bioinformatics databases]]

[[de:Transporter Classification Database]]

[[it:Classificazione TC]]

[[ru:Транспортные белки]]