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'''Hypodermin C''' ({{EC number|3.4.21.49}}, ''Hypoderma collagenase'') is an [[enzyme]].<ref>{{cite journal | vauthors = Lecroisey A, Boulard C, Keil B | title = Chemical and enzymatic characterization of the collagenase from the insect Hypoderma lineatum | journal = European Journal of Biochemistry | volume = 101 | issue = 2 | pages = 385–93 | date = November 1979 | pmid = 230030 | doi = 10.1111/j.1432-1033.1979.tb19730.x | doi-access = free }}</ref><ref>{{cite journal | vauthors = Lecroisey A, Keil B | title = Specificity of the collagenase from the insect Hypoderma lineatum | journal = European Journal of Biochemistry | volume = 152 | issue = 1 | pages = 123–30 | date = October 1985 | pmid = 2995028 | doi = 10.1111/j.1432-1033.1985.tb09171.x | doi-access = free }}</ref><ref>{{cite journal | vauthors = Lecroisey A, Gilles AM, De Wolf A, Keil B | title = Complete amino acid sequence of the collagenase from the insect Hypoderma lineatum | journal = The Journal of Biological Chemistry | volume = 262 | issue = 16 | pages = 7546–51 | date = June 1987 | doi = 10.1016/S0021-9258(18)47600-4 | doi-access = free | pmid = 3034899 }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
: [[Hydrolysis]] of proteins including native [[collagen]] at -Ala bond leaving an [[N-terminal]] (75%) and a [[C-terminal]] (25%) fragment
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