Endothelin converting enzyme 1: Difference between revisions

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{{Short description|Mammalian protein found in Homo sapiens}}

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'''Endothelin converting enzyme 1''', also known as '''ECE1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ECE1 endothelin converting enzyme 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1889| accessdate = }}</ref>

{{Infobox_gene}}

'''<span lang="fr" dir="ltr">Endothelin</span> converting enzyme 1''', also known as '''ECE1''', is an [[enzyme]] which in humans is encoded by the ''ECE1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ECE1 endothelin converting enzyme 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1889}}</ref><ref name="pmid7805846">{{cite journal | vauthors = Schmidt M, Kröger B, Jacob E, Seulberger H, Subkowski T, Otter R, Meyer T, Schmalzing G, Hillen H | title = Molecular characterization of human and bovine endothelin converting enzyme (ECE-1) | journal = FEBS Lett. | volume = 356 | issue = 2–3 | pages = 238–43 |date=December 1994 | pmid = 7805846 | doi = 10.1016/0014-5793(94)01277-6| doi-access = free }}</ref><ref name="pmid7864876">{{cite journal | vauthors = Shimada K, Matsushita Y, Wakabayashi K, Takahashi M, Matsubara A, Iijima Y, Tanzawa K | title = Cloning and functional expression of human endothelin-converting enzyme cDNA | journal = Biochem. Biophys. Res. Commun. | volume = 207 | issue = 2 | pages = 807–12 |date=February 1995 | pmid = 7864876 | doi = 10.1006/bbrc.1995.1258 | doi-access = free }}</ref>

== Function ==

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{{PBB_Summary

Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 ([[endothelin 1|EDN1]]), -2 ([[endothelin 2|EDN2]]), and -3 ([[endothelin 3|EDN3]]) to biologically active peptides.<ref name="entrez" />

| section_title =

| summary_text = Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1; MIM 131240), -2 (EDN2; MIM 131241), and -3 (EDN3; MIM 131242) to biologically active peptides.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: ECE1 endothelin converting enzyme 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1889| accessdate = }}</ref>

}}

==References==

{{reflist}}

==Further reading==

{{refbegin | 2}}

*{{cite journal | vauthors=Yorimitsu K, Moroi K, Inagaki N |title=Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2 |journal=Biochem. Biophys. Res. Commun. |volume=208 |issue= 2 |pages= 721–7 |year= 1995 |pmid= 7695628 |doi=10.1006/bbrc.1995.1397 |display-authors=etal}}

{{PBB_Further_reading

*{{cite journal | vauthors=Schmidt M, Kröger B, Jacob E |title=Molecular characterization of human and bovine endothelin converting enzyme (ECE-1) |journal=FEBS Lett. |volume=356 |issue= 2–3 |pages= 238–43 |year= 1995 |pmid= 7805846 |doi=10.1016/0014-5793(94)01277-6 |display-authors=etal|doi-access=free }}

| citations =

*{{cite journal | authorvauthors=YorimitsuShimada K, MoroiMatsushita KY, InagakiWakabayashi N, ''et al.''K |title=Cloning and sequencingfunctional expression of a human endothelin -converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2.cDNA |journal=Biochem. Biophys. Res. Commun. |volume=208207 |issue= 2 |pages= 721–7807–12 |year= 1995 |pmid= 76956287864876 |doi= 10.1006/bbrc.1995.1258 |display-authors=etal|doi-access=free }}

*{{cite journal | authorvauthors=SchmidtValdenaire MO, Kröger B, JacobRohrbacher E, ''etMattei al.''MG |title=Molecular characterizationOrganization of humanthe andgene bovineencoding endothelinthe human endothelin-converting enzyme (ECE-1). |journal=FEBSJ. Biol. LettChem. |volume=356270 |issue= 2-350 |pages= 238–4329794–8 |year= 19951996 |pmid= 78058468530372 |doi=10.1074/jbc.270.50.29794 |doi-access=free }}

*{{cite journal | authorvauthors=ShimadaMatsuoka KR, MatsushitaSawamura YT, WakabayashiYamada K, ''et al.'' |title=CloningHuman andendothelin functionalconverting expressionenzyme ofgene human(ECE1) endothelin-convertingmapped enzymeto chromosomal region cDNA1p36.1 |journal=BiochemCytogenet. Biophys. Res.Cell CommunGenet. |volume=20772 |issue= 24 |pages= 807–12322–4 |year= 19951996 |pmid= 78648768641140 |doi= 10.10061159/bbrc.1995.1258000134214 |display-authors=etal}}

*{{cite journal | authorvauthors=ValdenaireOrzechowski OHD, RohrbacherRichter ECM, MatteiFunke-Kaiser MGH |title=OrganizationEvidence of thealternative genepromoters encodingdirecting theisoform-specific expression of human endothelin-converting enzyme (ECE-1). mRNA in cultured endothelial cells |journal=J. BiolMol. ChemMed. |volume=27075 |issue= 507 |pages= 29794–8512–21 |year= 19961997 |pmid= 85303729253714 |doi=10.1007/s001090050136 |s2cid=34633812 |display-authors=etal}}

*{{cite journal | authorvauthors=MatsuokaSchweizer RA, SawamuraValdenaire TO, YamadaNelböck K, ''et al.''P |title=Human endothelin -converting enzyme gene (ECE1ECE-1): mappedthree toisoforms chromosomalwith regiondistinct 1p36.1.subcellular localizations |journal=CytogenetBiochem. Cell GenetJ. |volume=72328 |issue= 4 Pt 3|pages= 322–4871–7 |year= 19961998 |pmid= 86411409396733 |doi= 10.1042/bj3280871| pmc=1218999 |display-authors=etal}}

*{{cite journal | authorvauthors=OrzechowskiKido HDT, RichterSawamura CMT, Funke-KaiserMasaki H, ''et al.''T |title=EvidenceThe ofprocessing alternative promoters directing isoform-specific expressionpathway of human endothelin-converting enzyme-1 mRNA in cultured endothelial cells.production |journal=J. MolCardiovasc. MedPharmacol. |volume=7531 |issuepages= 7S13–5 |pagesyear= 512–211998 |yearissue=Suppl 19971 |pmid= 92537149595387 |doi=10.1097/00005344-199800001-00006 |doi-access=free }}

*{{cite journal | authorvauthors=SchweizerHofstra ARM, Valdenaire O, NelböckArch P, ''et al.''E |title=HumanA loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1): three isoformsassociated with distinctHirschsprung subcellulardisease, localizations.cardiac defects, and autonomic dysfunction |journal=BiochemAm. J. Hum. Genet. |volume=328 ( Pt 3)64 |issue= 1 |pages= 871–7304–8 |year= 19981999 |pmid= 93967339915973 |doi=10.1086/302184 | pmc=1377732 |display-authors=etal}}

*{{cite journal | authorvauthors=KidoLee TS, SawamuraLin TM, MasakiMele TA |title=TheProteolytic processing pathway of big endothelin-13 production.by the kell blood group protein |journal=J. Cardiovasc. Pharmacol.Blood |volume=31 Suppl 194 |issue= 4 |pages= S13–51440–50 |year= 19981999 |pmid= 959538710438732 |doi= 10.1182/blood.V94.4.1440|display-authors=etal}}

*{{cite journal | authorvauthors=Hofstra RM, Valdenaire O, ArchLepailleur-Enouf ED, ''etEgidy al.''G |title=A loss-of-functionfourth mutationisoform in theof endothelin-converting enzyme 1 (ECE-1) associatedis withgenerated Hirschsprungfrom disease,an cardiacadditional defects,promoter andmolecular autonomiccloning dysfunction.and characterization |journal=AmEur. J. Hum. GenetBiochem. |volume=64264 |issue= 12 |pages= 304–8341–9 |year= 1999 |pmid= 991597310491078 |doi=10.1046/j.1432-1327.1999.00602.x |display-authors=etal|doi-access=free }}

*{{cite journal | authorvauthors=LeeFahnoe SDC, LinJohnson MGD, MeleHerman ASB, ''etAhn al.''K |title=ProteolyticDisulfide processingbonds ofin big endothelinET-31 byare essential for the kellspecific bloodcleavage groupat protein.the Trp(21)-Val(22) bond by soluble endothelin converting enzyme-1 from baculovirus/insect cells |journal=BloodArch. Biochem. Biophys. |volume=94373 |issue= 42 |pages= 1440–50385–93 |year= 19992000 |pmid= 1043873210620363 |doi= 10.1006/abbi.1999.1586 }}

*{{cite journal | authorvauthors=Valdenaire O, LepailleurLópez-EnoufOngil DS, EgidySenchak GV, ''etSaura al.''M |title=ASuperoxide fourth isoformregulation of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterization. |journal=EurJ. JBiol. BiochemChem. |volume=264275 |issue= 234 |pages= 341–926423–7 |year= 19992000 |pmid= 1049107810833511 |doi= 10.1074/jbc.M000767200 |display-authors=etal|doi-access=free }}

*{{cite journal | authorvauthors=FahnoeHachiya DCA, JohnsonKobayashi GDT, HermanTakema SBY, AhnImokawa KG |title=DisulfideBiochemical bondscharacterization inof bigendothelin-converting ETenzyme-11alpha arein essentialcultured forskin-derived thecells specificand cleavageits atpostulated therole Trp(21)-Val(22)in bondthe bystimulation solubleof endothelinmelanogenesis convertingin enzyme-1human from baculovirus/insect cells.epidermis |journal=ArchJ. BiochemBiol. BiophysChem. |volume=373277 |issue= 27 |pages= 385–935395–403 |year= 20002002 |pmid= 1062036311723113 |doi= 10.10061074/abbijbc.1999.1586M105874200 |doi-access= free }}

*{{cite journal | authorvauthors=López-OngilInguimbert SN, SenchakCoric VP, SauraPoras M, ''et al.''H |title=SuperoxideToward regulationan optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme. (ACE), and neutral endopeptidase (NEP) |journal=J. BiolMed. Chem. |volume=27545 |issue= 347 |pages= 26423–71477–86 |year= 20002002 |pmid= 1083351111906289 |doi= 10.10741021/jbc.M000767200jm0005454 |display-authors=etal}}

*{{cite journal | authorvauthors=HachiyaMacLeod AKJ, KobayashiHusain TRD, TakemaGage YDA, ImokawaAhn GK |title=BiochemicalConstitutive characterizationphosphorylation of human endothelin-converting enzyme-1alpha1 in cultured skin-derived cells and its postulated role in the stimulation of melanogenesis in human epidermis.isoforms |journal=J. Biol. Chem. |volume=277 |issue= 748 |pages= 5395–40346355–63 |year= 20022003 |pmid= 1172311312244060 |doi= 10.1074/jbc.M105874200M207972200 |doi-access= free }}

*{{cite journal | authorvauthors=InguimbertMuller NL, CoricBarret PA, PorasEtienne H, ''et al.''E |title=Toward an optimal joint recognition of the S1' subsitesHeterodimerization of endothelin -converting enzyme-1 (ECE-1),isoforms angiotensinregulates convertingthe enzymesubcellular (ACE),distribution andof neutralthis endopeptidase (NEP).metalloprotease |journal=J. MedBiol. Chem. |volume=45278 |issue= 71 |pages= 1477–86545–55 |year= 20022003 |pmid= 1190628912393864 |doi= 10.1074/jbc.M208949200 |display-authors=etal|doi-access=free }}

*{{cite journal | authorvauthors=MacLeodEckman KJEA, HusainWatson RDM, GageMarlow DA, Ahn KL |title=ConstitutiveAlzheimer's phosphorylationdisease ofbeta-amyloid humanpeptide is increased in mice deficient in endothelin-converting enzyme-1 isoforms. |journal=J. Biol. Chem. |volume=277278 |issue= 484 |pages= 46355–632081–4 |year= 2003 |pmid= 1224406012464614 |doi= 10.1074/jbc.M207972200C200642200 |display-authors=etal|doi-access=free }}

*{{cite journal | authorvauthors=MullerStrausberg LRL, BarretFeingold AEA, EtienneGrouse E, ''et al.''LH |title=HeterodimerizationGeneration ofand endothelin-convertinginitial enzyme-1analysis isoformsof regulatesmore thethan subcellular15,000 distributionfull-length ofhuman thisand metalloprotease.mouse cDNA sequences |journal=JProc. BiolNatl. ChemAcad. Sci. U.S.A. |volume=27899 |issue= 126 |pages= 545–5516899–903 |year= 2003 |pmid= 1239386412477932 |doi= 10.10741073/jbcpnas.M208949200242603899 | pmc=139241 |display-authors=etal |bibcode=2002PNAS...9916899M|doi-access=free }}

*{{cite journal | authorvauthors=EckmanMasatsugu EAK, WatsonItoh MH, MarlowChun L, ''et al.''TH |title=Alzheimer'sShear diseasestress beta-amyloidattenuates peptide is increased inendothelin mice deficient inand endothelin-converting enzyme. expression through oxidative stress |journal=JRegul. Biol. ChemPept. |volume=278111 |issue= 41–3 |pages= 2081–413–9 |year= 2003 |pmid= 1246461412609744 |doi= 10.10741016/jbc.C200642200S0167-0115(02)00219-7 |display-authors=etal|hdl=2433/147555 |s2cid=37039969 |hdl-access=free }}

*{{cite journal | authorvauthors=StrausbergSmollich RLM, FeingoldGötte EAM, GrouseYip LH, ''et al.''GW |title=GenerationOn andthe initial analysisrole of moreendothelin-converting thanenzyme 15,0001 full(ECE-length human1) and mouseneprilysin cDNAin sequences.human breast cancer |journal=Proc.Breast Natl.Cancer AcadRes. Sci. U.S.ATreat. |volume=99106 |issue= 263 |pages= 16899–903361–9 |year= 20032007 |pmid= 1247793217295044 |doi= 10.10731007/pnas.242603899s10549-007-9516-9 |s2cid=5546294 |display-authors=etal}}

*{{cite journal | author=Masatsugu K, Itoh H, Chun TH, ''et al.'' |title=Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress. |journal=Regul. Pept. |volume=111 |issue= 1-3 |pages= 13–9 |year= 2003 |pmid= 12609744 |doi= }}

*{{cite journal | author=Smollich M, Götte M, Yip GW, ''et al.'' |title=On the role of endothelin-converting enzyme 1 (ECE-1) and neprilysin in human breast cancer. |journal=Breast Cancer Res. Treat. |volume=106 |issue= 3 |pages= 361–9 |year= 2007 |pmid= 17295044 |doi= 10.1007/s10549-007-9516-9 }}

}}

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