Microprocessor complex subunit DGCR8: Difference between revisions

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Line 1: {{Short description\|Protein-coding gene in the species Homo sapiens}} {{cs1 config\|name-list-style=vanc}} {{Infobox_gene}} The ''' microprocessor complex subunit DGCR8''' ''([[DiGeorge syndrome]] critical region 8)'' is a [[protein]] that in humans is encoded by the {{gene\|DGCR8}} [[gene]].<ref name="entrez">{{cite web \| title = Entrez Gene: DGCR8 DiGeorge syndrome critical region gene 8\| url = https://www.ncbi.nlm.nih.gov/~~sites/entrez~~gene?Db=gene&Cmd=ShowDetailView&TermToSearch=54487\| ~~accessdate~~access-date = }}</ref> In other animals, particularly the common [[model organism]]s ''[[Drosophila melanogaster]]'' and ''[[Caenorhabditis elegans]]'', the protein is known as ''Pasha'' (partner of [[Drosha]]).<ref>{{cite journal \| vauthors = Denli AM, Tops BB, Plasterk RH, Ketting RF, Hannon GJ \| title = Processing of primary microRNAs by the Microprocessor complex \| journal = Nature \| volume = 432 \| issue = 7014 \| pages = 231–5 \| date = Nov 2004 \| pmid = 15531879 \| doi = 10.1038/nature03049 \| bibcode = 2004Natur.432..231D \| s2cid = 4425505 }}</ref> It is a required component of the [[RNA interference]] pathway. == Function == Line 18 ⟶ 20: * {{cite journal \| vauthors = Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N, Shiekhattar R \| title = The Microprocessor complex mediates the genesis of microRNAs \| journal = Nature \| volume = 432 \| issue = 7014 \| pages = 235–40 \| date = Nov 2004 \| pmid = 15531877 \| doi = 10.1038/nature03120 \| bibcode = 2004Natur.432..235G \| s2cid = 4389261 }} * {{cite journal \| vauthors = Han J, Lee Y, Yeom KH, Kim YK, Jin H, Kim VN \| title = The Drosha-DGCR8 complex in primary microRNA processing \| journal = Genes & Development \| volume = 18 \| issue = 24 \| pages = 3016–27 \| date = Dec 2004 \| pmid = 15574589 \| pmc = 535913 \| doi = 10.1101/gad.1262504 }} * {{cite journal \| vauthors = Landthaler M, Yalcin A, Tuschl T \| title = The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis \| journal = Current Biology \| volume = 14 \| issue = 23 \| pages = 2162–7 \| date = Dec 2004 \| pmid = 15589161 \| doi = 10.1016/j.cub.2004.11.001 \| bibcode = 2004CBio...14.2162L \| hdl = 11858/00-001M-0000-0012-EB83-3 \| s2cid = 13266269 \| hdl-access = free }} * {{cite journal \| vauthors = Han J, Lee Y, Yeom KH, Nam JW, Heo I, Rhee JK, Sohn SY, Cho Y, Zhang BT, Kim VN \| title = Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex \| journal = Cell \| volume = 125 \| issue = 5 \| pages = 887–901 \| date = Jun 2006 \| pmid = 16751099 \| doi = 10.1016/j.cell.2006.03.043 \| doi-access = free }} * {{cite journal \| vauthors = Faller M, Matsunaga M, Yin S, Loo JA, Guo F \| title = Heme is involved in microRNA processing \| journal = Nature Structural & Molecular Biology \| volume = 14 \| issue = 1 \| pages = 23–9 \| date = Jan 2007 \| pmid = 17159994 \| doi = 10.1038/nsmb1182 \| s2cid = 17463646 }}