GDB Human Genome Database: Difference between revisions

Revision as of 00:50, 30 January 2023

Latest revision as of 11:04, 16 July 2025

(3 intermediate revisions by 3 users not shown)

Line 1:

{{Short description|Haman Genome}}

{{Infobox biodatabase

|title = GDB Human Genome Database

Line 34 ⟶ 35:

In 1989 the [[Howard Hughes Medical Institute]] provided funding to establish a central repository for human [[genetic map]]ping data. This project ultimately resulted in the creation of the GDB Human Genome DataBase in September 1990.<ref name="nar1993">{{cite journal |last1=Cuticchia |first1=A.Jamie |last2=Fasman |first2=Kenneth H. |last3=Kingsbury |first3=David T. |last4=Robbins |first4=Robert J. |last5=Pearson |first5=Peter L. |title=The GDB TM human genome data base anno 1993 |journal=Nucleic Acids Research |date=1993 |volume=21 |issue=13 |pages=3003–3006 |doi=10.1093/nar/21.13.3003|pmid=8332522 |pmc=309725 }}</ref><ref name="hum-mutat">{{cite journal |last1=Cuticchia |first1=A.J. |title=Future vision of the GDB human genome database |journal=Human Mutation |date=27 Dec 1999 |volume=15 |issue=1 |pages=62–67 |doi=10.1002/(SICI)1098-1004(200001)15:1<62::AID-HUMU13>3.0.CO;2-R |pmid=10612824|s2cid=25606440 |doi-access=free }}</ref> In order to ensure a high degree of quality, records within GDB were subjected to a curation process by human genetics specialists, including the [[HUGO Gene Nomenclature Committee]].<ref name="nar1998">{{cite journal |last1=Letovsky |first1=S. |title=GDB: the Human Genome Database |journal=Nucleic Acids Research |date=1 January 1998 |volume=26 |issue=1 |pages=94–99 |doi=10.1093/nar/26.1.94|pmid=9399808 |pmc=147203 |doi-access=free }}</ref>

Established under the leadership of Peter Pearson and Dick Lucier,<ref name="nar1991">{{cite journal |last1=Pearson |first1=P.L. |title=The genome data base (GDB)--a human gene mapping repository |journal=Nucleic Acids Research |date=25 April 1991 |volume=19 |issue=suppl |pages=2237–2239 |doi=10.1093/nar/19.suppl.2237|pmid=2041809 |pmc=331357 }}</ref> GDB received financial support from the [[US Department of Energy]] and the [[National Institutes of Health]].<ref name="nar1993" /> Located at the [[Johns Hopkins University School of Medicine]], GDB became a source of high quality mapping data which were made available both online as well as through numerous printed publications.{{cncitation needed|date=September 2020}} The project was supported internationally by the EU, Japan, and other countries.

The GDB had several directors in its time. Peter Pearson, David T. Kingsbury, Stantley Letovsky, Peter Li, and [[A. Jamie Cuticchia]].{{cncitation needed|date=September 2020}}

InFunds 1998,from the changeUS Department of focusEnergy inthat thewere humanpreviously genomeallocated projectfor redirectedGDB USwere Departmenttransferred ofin Energy1998 fundsdue whichto werethe previouslyshift availablein foremphasis GDBin the human genome project.<ref name="gdb-sackings">{{cite journal |last1=Bonetta |first1=Laura |title=Sackings leave gene database floundering |journal=Nature |date=November 2001 |volume=414 |issue=6862 |pages=384 |doi=10.1038/35106703|pmid=11719765 |bibcode=2001Natur.414..384B |doi-access=free }}</ref> However that same year, [[A. Jamie Cuticchia]] obtained funding from Canadian public and private sources to continue the operations of GDB. While the data curation continued to be performed at Johns Hopkins, GDB central operations were moved to The Hospital for Sick Children (HSC) in Toronto, Ontario, Canada.<ref name="canada-move">{{cite web |title=Human Genome News Vol. 10, No. 1-2, February 1999 |url=https://web.ornl.gov/sci/techresources/Human_Genome/publicat/hgn/v10n1/21gdb.shtml |website=web.ornl.gov |accessdate=3 September 2020}}</ref> In November 2001, the HSC fired Cuticchia due to a dispute over the GDB website ___domain name.<ref name="gdb-sackings" />

In 2003 [[RTI International]] became the new host for GDB where it continued to be maintained as a public resource;<ref>{{cite journalbook |last1=Seewald |first1=A.K. |title=Knowledge Exploration in Life Science Informatics |chapter=Ranking for BioMinTMedical Annotation: investigatingInvestigating performancePerformance, localLocal searchSearch and homonymyHomonymy recognitionRecognition |journalseries=ProceedingsLecture of the Symposium on Knowledge ExplorationNotes in LifeComputer Science Informatics (KELSI 2004) |date=2004 |volume=3303 |pages=109–123 |doi=10.1007/978-3-540-30478-4_10 |isbn=978-3-540-23927-7 |citeseerx=10.1.1.117.8840 }}</ref> GDB was closed in 2008 after control of the project reverted to Johns Hopkins.<ref name="closure">{{cite journal |last1=Galperin |first1=M. Y. |last2=Cochrane |first2=G. R. |title=Nucleic Acids Research annual Database Issue and the NAR online Molecular Biology Database Collection in 2009 |journal=Nucleic Acids Research |date=1 January 2009 |volume=37 |issue=Database |pages=D1–D4 |doi=10.1093/nar/gkn942|pmid=19033364 |pmc=2686608 |doi-access=free }}</ref>

==References==