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''Main Article'': <u>[[Sex linkage]]</u>{{short description|Mode of inheritance}}
[[File:X-linked recessive (2).svg|thumb|right|upright=1.75|X-linked recessive inheritance]]
'''X-linked recessive inheritance''' is a mode of [[Mendelian inheritance|inheritance]] in which a [[mutation]] in a [[gene]] on the [[X chromosome]] causes the [[phenotype]] to be always expressed in males (who are necessarily [[
X-linked inheritance means that the gene causing the trait or the disorder is located on the X chromosome. Females have two X chromosomes while males have one X and one [[Y chromosome]]. Carrier females who have only one copy of the mutation do not usually express the phenotype, although differences in [[X-chromosome inactivation]] (known as [[skewed X-inactivation]]) can lead to varying degrees of clinical expression in carrier females, since some cells will express one X [[allele]] and some will express the other. The current estimate of sequenced X-linked genes is 499, and the total, including vaguely defined traits, is 983.<ref>{{cite web|url=https://www.ncbi.nlm.nih.gov/Omim/mimstats.html|title=OMIM X-linked Genes|website=nih.gov|access-date=3 May 2018|url-status=
== Patterns of
[[File:Haemophilia family tree.GIF|thumb|Patterns of X-
In humans, inheritance of X-linked recessive traits follows a unique pattern made up of three points.
* Second,
==
A few scholars have suggested discontinuing the use of the terms ''dominant'' and ''recessive'' when referring to [[X-linked inheritance]].<ref name=":0">{{cite journal|last1=Dobyns|first1=William B.|last2=Filauro|first2=Allison|last3=Tomson|first3=Brett N.|last4=Chan|first4=April S.|last5=Ho|first5=Allen W.|last6=Ting|first6=Nicholas T.|last7=Oosterwijk|first7=Jan C.|last8=Ober|first8=Carole|year=2004|title=Inheritance of most X-linked traits is not dominant or recessive, just X-linked|journal=American Journal of Medical Genetics|volume=129A|issue=2|pages=136–43|doi=10.1002/ajmg.a.30123|pmid=15316978|s2cid=42108591}}</ref> The possession of two X chromosomes in females leads to dosage issues which are alleviated by [[X-inactivation]].<ref>{{Cite journal|last1=Shvetsova|first1=Ekaterina|last2=Sofronova|first2=Alina|last3=Monajemi|first3=Ramin|last4=Gagalova|first4=Kristina|last5=Draisma|first5=Harmen H. M.|last6=White|first6=Stefan J.|last7=Santen|first7=Gijs W. E.|last8=Chuva de Sousa Lopes|first8=Susana M.|last9=Heijmans|first9=Bastiaan T.|last10=van Meurs|first10=Joyce|last11=Jansen|first11=Rick|date=March 2019|title=Skewed X-inactivation is common in the general female population|journal=European Journal of Human Genetics|language=en|volume=27|issue=3|pages=455–465|doi=10.1038/s41431-018-0291-3|pmid=30552425|pmc=6460563|issn=1476-5438|doi-access=free}}</ref> Stating that the highly variable [[penetrance]] of X-linked traits in females as a result of mechanisms such as skewed X-inactivation or [[somatic mosaicism]] is difficult to reconcile with standard definitions of dominance and recessiveness, scholars have suggested referring to traits on the X chromosome simply as ''X-
==Examples==
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===Most common===
The most common X-linked recessive disorders are:<ref name=gpnotebook>[http://www.gpnotebook.co.uk/simplepage.cfm?ID=-1341784030 GP Notebook - X-linked recessive disorders] {{webarchive|url=https://web.archive.org/web/20110613144555/http://www.gpnotebook.co.uk/simplepage.cfm?ID=-1341784030 |date=2011-06-13 }} Retrieved on 5 Mars, 2009</ref>
* [[Red–green color blindness]],
* [[Hemophilia A]], a [[coagulation|blood clotting]] disorder caused by a [[mutation]] of the [[Factor VIII]] [[gene]] and leading to a deficiency of Factor VIII. It was once thought to be the "royal disease" found in the descendants of Queen Victoria. This is now known to have been Hemophilia B (see below).<ref>{{cite web|author= Michael Price|title= Case Closed: Famous Royals Suffered From Hemophilia|url=
▲*[[Red–green color blindness]], a very common trait in humans and frequently used to explain X-linked disorders.<ref>{{cite web|url=https://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=303800|title=OMIM Color Blindness, Deutan Series; CBD|website=nih.gov|access-date=3 May 2018|url-status=live|archive-url=https://web.archive.org/web/20090929025156/http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=303800|archive-date=29 September 2009}}</ref> Between seven and ten percent of men and 0.49% to 1% of women are affected. Its commonness may be explained by its relatively benign nature. It is also known as daltonism.
* [[Hemophilia B]], also known as Christmas disease,<ref>[http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=181&contentid=46&rptname=bleeding "Hemophilia B".] {{webarchive|url=https://web.archive.org/web/20071201092338/http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=181&contentid=46&rptname=bleeding |date=2007-12-01 }} National Hemophilia Foundation.</ref> a [[coagulation|blood clotting]] disorder caused by a [[mutation]] of the [[Factor IX]] [[gene]] and leading to a deficiency of Factor IX. It is rarer than [[hemophilia A]]. As noted above, it was [[Haemophilia in European royalty|common]] among the descendants of Queen Victoria.▼
▲*[[Hemophilia A]], a [[coagulation|blood clotting]] disorder caused by a [[mutation]] of the [[Factor VIII]] [[gene]] and leading to a deficiency of Factor VIII. It was once thought to be the "royal disease" found in the descendants of Queen Victoria. This is now known to have been Hemophilia B (see below).<ref>{{cite web|author= Michael Price|title= Case Closed: Famous Royals Suffered From Hemophilia|url= http://news.sciencemag.org/biology/2009/10/case-closed-famous-royals-suffered-hemophilia|work= ScienceNOW Daily News|publisher= AAAS|date= 8 October 2009|access-date= 9 October 2009|url-status= live|archive-url= https://web.archive.org/web/20131020190735/http://news.sciencemag.org/biology/2009/10/case-closed-famous-royals-suffered-hemophilia|archive-date= 20 October 2013}}</ref><ref>{{cite journal |last1=Rogaev |first1=Evgeny I. |last2=Grigorenko |first2=Anastasia P. |last3=Faskhutdinova |first3=Gulnaz |last4=Kittler |first4=Ellen L. W. |last5=Moliaka |first5=Yuri K. |year=2009 |title=Genotype Analysis Identifies the Cause of the 'Royal Disease' |journal=Science |volume=326 |issue=5954 |pages=817 |bibcode=2009Sci...326..817R |doi=10.1126/science.1180660 |pmid=19815722|s2cid=206522975 }}</ref>
* [[Duchenne muscular dystrophy]], which is associated with mutations in the [[dystrophin]] gene. It is characterized by rapid progression of muscle degeneration, eventually leading to loss of skeletal muscle control, respiratory failure, and death.
▲*[[Hemophilia B]], also known as Christmas disease,<ref>[http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=181&contentid=46&rptname=bleeding "Hemophilia B".] {{webarchive|url=https://web.archive.org/web/20071201092338/http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=181&contentid=46&rptname=bleeding |date=2007-12-01 }} National Hemophilia Foundation.</ref> a [[coagulation|blood clotting]] disorder caused by a [[mutation]] of the [[Factor IX]] [[gene]] and leading to a deficiency of Factor IX. It is rarer than [[hemophilia A]]. As noted above, it was [[Haemophilia in European royalty|common]] among the descendants of Queen Victoria.
* [[
* [[X-linked ichthyosis]], a form of [[ichthyosis]] caused by a [[genetic disorder|hereditary deficiency]] of the [[steroid sulfatase]] (STS) enzyme. It is fairly rare, affecting one in 2,000 to one in 6,000 males.<ref name=PedDerm>{{cite book |author1=Carlo Gelmetti |author2=Caputo, Ruggero |title=Pediatric Dermatology and Dermatopathology: A Concise Atlas |publisher=T&F STM |year=2002 |isbn=1-84184-120-X |page=160}}▼
▲*[[X-linked ichthyosis]], a form of [[ichthyosis]] caused by a [[genetic disorder|hereditary deficiency]] of the [[steroid sulfatase]] (STS) enzyme. It is fairly rare, affecting one in 2,000 to one in 6,000 males.<ref name=PedDerm>{{cite book |author1=Carlo Gelmetti |author2=Caputo, Ruggero |title=Pediatric Dermatology and Dermatopathology: A Concise Atlas |publisher=T&F STM |year=2002 |isbn=1-84184-120-X |page=160}}
</ref>
* [[X-linked agammaglobulinemia]] (XLA), which affects the body's ability to fight infection. XLA patients do not generate mature [[B cell]]s.<ref name="titleX-linked Agammaglobulinemia: Immunodeficiency Disorders: Merck Manual Professional">{{cite web |url=http://www.merck.com/mmpe/sec13/ch164/ch164o.html |title=X-linked Agammaglobulinemia: Immunodeficiency Disorders: Merck Manual Professional |access-date=2008-03-01 |url-status=live |archive-url=https://web.archive.org/web/20080218140736/http://www.merck.com/mmpe/sec13/ch164/ch164o.html |archive-date=2008-02-18 }}</ref> B cells are part of the immune system and normally manufacture antibodies (also called [[immunoglobulin]]s) which defends the body from infections (the [[humoral]] response). Patients with untreated XLA are prone to develop serious and even fatal infections.<ref name=ConleyXLA>{{cite web|url=http://www.stjude.org/disease-summaries/0,2557,449_2164_6526,00.html|title=Diseases Treated at St. Jude|website=stjude.org|access-date=3 May 2018|url-status=live|archive-url=https://web.archive.org/web/20070815195658/http://www.stjude.org/disease-summaries/0,2557,449_2164_6526,00.html|archive-date=15 August 2007}}</ref>
* [[Glucose-6-phosphate dehydrogenase deficiency]], which causes nonimmune hemolytic anemia in response to a number of causes, most commonly infection or exposure to certain medications, chemicals, or foods. Commonly known as "favism", as it can be triggered by chemicals existing naturally in broad (or fava) beans.<ref>{{cite web|url=http://patient.info/doctor/favism|title=Favism - Doctor|website=patient.info|access-date=3 May 2018|url-status=live|archive-url=https://web.archive.org/web/20171121185504/https://patient.info/doctor/favism|archive-date=21 November 2017}}</ref>
===Less common disorders===
{{see also|X-linked intellectual disability}}
Theoretically, a mutation in any of the [[:Category:Genes on human chromosome X|genes on chromosome X]] may cause disease, but below are some notable ones, with short description of symptoms:
* [[Adrenoleukodystrophy]]; leads to progressive brain damage, failure of the adrenal glands, and eventually death.▼
▲* [[Adrenoleukodystrophy]]; leads to progressive brain damage, failure of the adrenal glands and eventually death.
* [[Alport syndrome]]; glomerulonephritis, endstage kidney disease, and hearing loss. A minority of Alport syndrome cases are due to an autosomal recessive mutation in the gene coding for [[type IV collagen]].
* [[Androgen insensitivity syndrome]]; variable degrees of undervirilization and/or infertility in XY persons of either sex
* [[Barth syndrome]]; metabolism distortion, delayed motor skills, stamina deficiency, hypotonia, chronic fatigue, delayed growth, cardiomyopathy, and compromised immune system.
* [[Blue cone monochromacy]]; low vision acuity, color blindness, photophobia, infantile nystagmus.
* [[Centronuclear myopathy]]; where cell nuclei are abnormally located in skeletal muscle cells. In CNM the nuclei are located at a position in the center of the cell, instead of their normal ___location at the periphery.
* [[Charcot–Marie–Tooth disease|Charcot–Marie–Tooth disease (CMTX2-3)]]; disorder of nerves (neuropathy) that is characterized by loss of muscle tissue and touch sensation, predominantly in the feet and legs but also in the hands and arms in the advanced stages of disease.
* [[Coffin–Lowry syndrome]]; severe
* [[Fabry disease]]; A lysosomal storage disease causing anhidrosis, fatigue, angiokeratomas, burning extremity pain, and ocular involvement.
* [[Hunter syndrome]]; potentially causing hearing loss, thickening of the heart valves leading to a decline in cardiac function, obstructive airway disease, sleep apnea, and enlargement of the liver and spleen.
* [[Hypohidrotic ectodermal dysplasia]], presenting with hypohidrosis, hypotrichosis, and hypodontia
* [[Kabuki syndrome]] (the ''[[KDM6A]]'' variant); multiple congenital anomalies and
* [[Lesch–Nyhan syndrome]]; neurologic dysfunction, cognitive and behavioral disturbances including self-mutilation, and uric acid overproduction (hyperuricemia)▼
* [[Spinal and bulbar muscular atrophy]]; muscle cramps and progressive weakness▼
* [[Lowe syndrome]]; hydrophthalmia, cataracts, intellectual disabilities, aminoaciduria, reduced renal ammonia production, and vitamin D-resistant rickets▼
▲*[[Lesch–Nyhan syndrome]]; neurologic dysfunction, cognitive and behavioral disturbances including self-mutilation, and uric acid overproduction (hyperuricemia)
▲* [[Lowe syndrome]]; hydrophthalmia, cataracts, intellectual disabilities, aminoaciduria, reduced renal ammonia production and vitamin D-resistant rickets
* [[Menkes disease]]; sparse and coarse hair, growth failure, and deterioration of the nervous system
* [[Nasodigitoacoustic syndrome]]; misshaped nose, [[brachydactyly]] of the [[distal phalanges]], sensorineural deafness
* [[Nonsyndromic deafness]]; hearing loss
* [[Norrie disease]]; cataracts
* [[Occipital horn syndrome]]; deformations in the skeleton
* [[Ocular albinism]]; lack of pigmentation in the eye
* [[Ornithine transcarbamylase deficiency]]; developmental delay and
* [[Oto-palato-digital syndrome]]; facial deformities, cleft palate, hearing loss
* [[Siderius X-linked mental retardation syndrome]]; cleft lip and palate with
* [[Simpson–Golabi–Behmel syndrome]]; coarse faces with protruding jaw and tongue, widened nasal bridge, and upturned nasal tip
▲* [[Spinal and bulbar muscular atrophy]] (SBMA), also known as Kennedy's disease; muscle cramps and progressive weakness
* [[Spinal muscular atrophy]] caused by [[UBE1]] gene mutation; weakness due to loss of the motor neurons of the spinal cord and brainstem
* [[Wiskott–Aldrich syndrome]]; eczema, thrombocytopenia, immune deficiency, and bloody diarrhea
* [[X-linked severe combined immunodeficiency]] (SCID); infections, usually causing death in the first years of life
* [[X-linked sideroblastic anemia]]; skin paleness, fatigue, dizziness, and enlarged spleen and liver.
==See also==
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==External links==
* [https://web.archive.org/web/20060913031720/http://genome.wellcome.ac.uk/doc_WTD020851.html X-linked diseases] from the [[Wellcome Trust]]
{{X-linked disorders}}
[Female X-linked disorders]
* [https://www.
[[Category:Genetics]]
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