Open Notebook Science Challenge: Difference between revisions

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[[Image:PCAChemicalSpace.png|thumb|PCA Chemical Space for Ethanol]]

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[[Image:PCAChemicalSpaceDescriptorChemicalSpace.png|PCAthumb|Descriptor Chemical Space for EthanolTHF: ALOGP vs. MW]]

The '''Open Notebook Science Challenge''' is a [[crowdsourcing]] research project which collects measurements of the non-aqueous solubility of organic compounds and publishes these as [[open data]]; findings are reported in an [[open notebook science]] manner. Although anyone may contribute research data, the competition is only open to post-secondary students in the US and UK.

Image:Example.jpg|Descriptor Chemical Space for THF: ALOGP vs. MW

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The '''Open Notebook Science Challenge''' is an [[Open Notebook Science]] [[Crowdsourcing]] research project<ref name="ONS Challenge">[http://onschallenge.wikispaces.com/ Open Notebook Science Challenge]</ref> that allows anyone to contribute to the effort of measuring the solubility of organic compounds in organic solvents and report their findings using open notebook science.

The challenge in turn forms part of the UsefulChem project, an ongoing [[open notebook science]] effort to synthesize and screen potential new anti-malarial drugs.<ref name="UsefulChem">[http://usefulchem.wikispaces.com/ UsefulChem]</ref> Data from the Solubility Challenge will be used to build predictive computational models of solubility for use in optimising syntheses.<ref name="predictions">[http://rguha.wordpress.com/2009/01/14/ons-solubility-predictions/ ONS solubility modeling and prediction]</ref>

The challenge began on September 28, 2008<ref name="began">[http://usefulchem.blogspot.com/2008/09/open-notebook-science-challenge.html The beginning of the Open Notebook Science challenge]</ref> and now involves researchers and their students in at least 4 different countries<ref name="experiments">[http://onschallenge.wikispaces.com/list+of+experiments List of experiments]</ref> and has resulted in the measurement of over 375 solubility measurements<ref name=measurements>[http://oru.edu/cccda/sl/chemspace/cs.php Solubility of Organic Compounds in Organic Solvents]</ref>.

The challenge began on September 28, 2008<ref name="began">[httphttps://usefulchem.blogspot.com/2008/09/open-notebook-science-challenge.html The beginning of the Open Notebook Science challenge]</ref> and, nowas of February 2014, involves researchers and their students infrom at least 4 different countriesinstitutions<ref name="experiments">[http://onschallenge.wikispaces.com/list+of+experiments List of experiments]</ref> and has resulted in the measurementacquisition of over 3757672 solubility measurements.<ref name=measurements>[http://lxsrv7.oru.edu/cccda~alang/slonsc/chemspace/cs.php Solubility of Organic Compounds in Organic Solvents]</ref>.

== Prizes ==

To encourage participation, each month an award<ref name="award">[http://www.oru.edu/news/view_news.php?id=1010 A News Story Discussing the Awards]</ref> is given to the student who does, in the opinion of the judges,<ref name="judges">[http://onschallenge.wikispaces.com/judges ONS Challenge judges]</ref>, the best work. In order to participate, students have to be a US or UK resident.<ref name="rules">[http://onschallenge.wikispaces.com/submetaawards08 ONS Challenge Rules]</ref>. The award is a US$500 cash prize. andThe first three winners also received a year's subscription to the journal ''[[Nature (journal)|Nature]]''. The awards are sponsored by [[Submeta]]<ref name="submeta">[http://www.submeta.org/index.html submeta]</ref> and ''Nature''.

== ChemicalRequest Donationsan experiment ==

As well as concentrating on compounds related to the [[Ugi reaction]], the ONSchallenge allows anyone to request a solubility measurement experiment.<ref name="request">[lxsrv7.oru.edu/~alang/onsc/solubility/solubility.php request a solubility measurement experiment]</ref>

[[Sigma Aldrich]] is also an official sponsor of the Open Notebook Science challenge. Sigma Aldrich is participating by donating and shipping requested chemicals to any experimenters in the US or UK<ref ="Sigma">[http://usefulchem.blogspot.com/2009/02/sigma-aldrich-ships-ons-solubility.html Sigma Aldrich's involvement with the ONS challenge]</ref> for free.

== Chemical donations ==

[[Sigma Aldrich]] is also an official sponsor of the Open Notebook Science challengeChallenge. Sigma Aldrich is participating by donating and shipping requested chemicals to any experimenters in the US or UK<ref name="Sigma">[httphttps://usefulchem.blogspot.com/2009/02/sigma-aldrich-ships-ons-solubility.html Sigma Aldrich's involvement with the ONS challenge]</ref> for free.

==References==

<references />

[[Category:Open access]]

== External links ==

* [https://web.archive.org/web/20081004212224/http://onschallenge.wikispaces.com/ Open Notebook Science Challenge]

[[Category:Open science]]

[[Category:Open accessdata]]

[[Category:Crowdsourcing]]