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{{Short description|Organization about biotech companies}}
The '''SiLA consortium''' is a [[Non-profit organization|not-for-profit]] membership organization formed by software suppliers, system integrators and pharma/biotech companies. This consortium for '''Standardization in Lab Automation''' (SiLA), develops and introduces new device and data interface standards allowing rapid integration of lab [[Automation]] hardware and data management systems. Highly skilled experts of member companies contribute in SiLA's technical work groups. Membership is open for institutions, corporations and individuals active in the life science lab automation industry. The SiLA consortium provides professional training, support and certification services to suppliers and system integrators implementing SiLA compliant interfaces.▼
{{No footnotes|date=August 2025}}
▲The '''consortium for Standardization in Lab Automation (SiLA
==Mission==
SiLA is the global initiative to standardize software interfaces in the field of life science research instrumentation, like [[Autosampler|autosamplers]], and [[
==Background==
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! Event
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| 2019 || Official SiLA 2 version 1.0 Release.
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| 2018 || Release Candidate of SiLA 2.
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==SiLA 2==
SiLA 2 addresses control and data interfaces between devices and process management, LIMS and Enterprise Systems. It is built to connect systems in a laboratory, such as [[
Enhancing the first standard SiLA 1.x by adopting proven concepts and applying already existing open standards and protocols in a "lean and mean" manner, SiLA 2 is designed to enable plug-and-play operations in the laboratory.
===Technical
SiLA 2 considers every entity in the modern laboratory as a service. Focus on behaviour and service oriented design structures leads to the Feature Definition Language (FDL). SiLA 2 is based on a microservice architecture. Relying on [[HTTP/2]], SiLA uses [[Protocol Buffers]] to serialize payload data. Furthermore, SiLA 2 uses the wire format provided by [[gRPC]].
===Structures===
SiLA 2 can split up into a Core and Feature level. The SiLA Core is written and maintained by the SiLA 2 Working group. SiLA Features are specific extensions that may change and evolve in any way.
SiLA's basic structure consists of a client – server communication model. The SiLA Server (≙ [[web server]]) exposes all its capabilities to the SiLA Client (≙ [[web client]]). Capabilities of the SiLA Server are grouped together as SiLA Features.
===Features===
The Feature concept serves as a common communication base for subject matter experts (SME), IT experts and end users. Each Feature is described by its Feature Definition, an XML-file containing information about parameters, interactions, data types, return values, etc. It exposes a certain number of Commands which model actions that can be performed by the SiLA Server.
===Cloud connectivity===
SiLA 2 offers cloud functionality. For connecting, the SiLA-Client and SiLA-Server switch roles and a “reverse-channel” will be established – This way the connection will be initialized by the SiLA-Server which can reside in a local network. Cloud capabilities are given while maintaining regulated security policies and safety by relying on standard gRPC and HTTP/2 connection handling and security models.
==SiLA 1.x ==
SiLA 1.x has been used from 2009 until 2018. But getting started with SiLA 1.x is not an easy process. Furthermore, As SiLA 1.x is based on XML/Soap which is considered outdated. It is now replaced by SiLA 2.
===SiLA 1.x
[[File:SiLA.Integration level.full.png|thumb|SiLA 1.x
The SiLA device interface standard covers all ISO/OSI levels of the device control interface from physical to application layer.
The interface standard is based on web service/[[SOAP]] communication with the devices. Commands are generally executed in asynchronous manner with an immediate response and a delayed event after completion of the command processing or after an error. Error recovery procedures are also supported and the general behavior of the devices is managed by a state machine. The state machine enables also complex behaviors like parallel processing of commands and command queuing.
By supporting three different integration levels, SiLA provides a unique, standardized interface between lab automation devices and process management systems so that also legacy devices can be integrated in SiLA compliant systems. SiLA compliance can be achieved by providing native, directly embedded SiLA device interfaces or by software only SiLA drivers and/or interface converters. The SiLA Device Control and Data Interface Standard eases and accelerates the integration and adaptation of systems through generic Device Class Interfaces providing Common Command Sets.
===SiLA 1.x
By grouping devices of the same functionality device classes can be created. SiLA Common Command Sets define commands for these device classes. SiLA defines the command names, the number of parameters and their names as well as the return data. Since commands and parameters are described in the WSDL documentation tag of the commands web service, a process management software (PMS) can automatically generate a list available commands for each device.
SiLA has defined about 30 device classes and a command library with about 100 commands. Commands range from mandatory commands that are needed to make transitions in the state machine, over required commands for the specific device class, to optional commands for which not every device in the device class might provide the functionality. In addition guidelines for the implementation of supplier-specific device commands and parameters are provided.
Some commands are applicable for almost every device class. For example, the commands SetParameter, GetParameter, ExecuteMethod are widely used. Also PrepareForOutput and PrepareForInput are common because they enable the transport mechanisms to transfer labware items from device to device. The mandatory commands include operations like Reset, Initialize, Abort and Pause. In addition
==Membership==
SiLA has formed a not-for-profit membership organisation. SiLA requires members to pay annual membership dues
==Organisation
[[File:SiLA.Board of Directors.full.png|thumb|SiLA board of directors]]
SiLA is a not-for-profit membership corporation with global footprint. Membership is open for institutions, corporations and individuals active in the life science lab automation industry.
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* [https://www.linkedin.com/posts/bryn-roberts-685171_labautomation-robotic-autonomous-activity-6582897402808676353-b4TK Autonomous Robot running with SiLA]
* [https://www.youtube.com/watch?v=B-LU1Tq7qYw Roche's Camunda-based AutoLab software]
* [https://onlinelibrary.wiley.com/doi/full/10.1002/elsc.202000053 Implementing a digital infrastructure for the lab using a central laboratory server and the SiLA2 communication standard, ''Engineering in Life Sciences'']
==Sources==
* [http://www.sila-standard.org/ SiLA homepage]
* [https://
* [https://drive.google.com/file/d/1QWrSD4-YBMwT9HTBzJe3TlBbJSGqq_LC/view SiLA 2 version 1.0]
* [https://gitlab.com/SiLA2/ SiLA 2 GitLab]
* [https://sila2.gitlab.io/sila_base/ Official SiLA 2 Documentation]
[[Category:
[[Category:Life sciences industry]]
[[Category:Data interchange standards]]
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