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'''''Mycobacterium avium ''complex''' is a group of [[mycobacteria]] comprising '''''Mycobacterium intracellulare''''' and '''''Mycobacterium avium''''' that are commonly grouped because they infect humans together; this group, in turn, is part of the group of [[nontuberculous mycobacteria]]. These bacteria cause [[Mycobacterium avium-intracellulare infection|''Mycobacterium avium-intracellulare'' infections]] or ''Mycobacterium avium'' complex infections in humans.<ref>{{cite web|title=Mycobacterium Avium Complex. MAI; MAC Information|url=https://patient.info/doctor/mycobacterium-avium-complex|publisher=Patient Info|date=29 August 2014}}</ref> These bacteria are common and are found in fresh and salt water, in household [[dust]] and in soil.<ref name=":0">{{Cite web|url=https://rarediseases.info.nih.gov/diseases/7123/mycobacterium-avium-complex-infections|archive-url=https://web.archive.org/web/20200208175000/https://rarediseases.info.nih.gov/diseases/7123/mycobacterium-avium-complex-infections|url-status=dead|archive-date=February 8, 2020|title=Mycobacterium Avium Complex infections {{!}} Genetic and Rare Diseases Information Center (GARD) – an NCATS Program|website=rarediseases.info.nih.gov|language=en|access-date=2020-03-29}}</ref> MAC bacteria usually cause infection in those who are [[immunocompromised]] or those with severe [[lung disease]].
==Description==
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'''Physiology'''
* Growth on [[Löwenstein-Jensen]] medium and [[Middlebrook 7H10 Agar|Middlebrook 7H10 agar]] occurs at 37{{nbsp}}°C after seven or more days.
* The complex can be (but is not often) resistant to [[isoniazid]], [[ethambutol]], [[rifampin]], and [[streptomycin]].<ref name="pmid29054853">{{cite journal | vauthors = Haworth CS, Banks J, Capstick T, Fisher AJ, Gorsuch T, Laurenson IF, Leitch A, Loebinger MR, Milburn HJ, Nightingale M, Ormerod P, Shingadia D, Smith D, Whitehead N, Wilson R, Floto RA | title = British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD) | journal = Thorax | volume = 72 | issue = Suppl 2 | pages = ii1–ii64 | date = November 2017 | pmid = 29054853 | doi = 10.1136/thoraxjnl-2017-210927 | doi-access = free }}</ref>
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