Signal transducing adaptor molecule: Difference between revisions

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{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Orphan|date=February 2009}}

{{PBB|geneid=8027Infobox_gene}}

'''Signal transducing adaptoradapter molecule (SH31''' ___domainis anda ITAM[[protein]] motif)that 1''',in alsohumans knownis asencoded by the '''STAM''', is a human [[gene]].<ref name="pmid8780729">{{cite journal | vauthors = Takeshita T, Arita T, Asao H, Tanaka N, Higuchi M, Kuroda H, Kaneko K, Munakata H, Endo Y, Fujita T, Sugamura K | title = Cloning of a novel signal-transducing adaptor molecule containing an SH3 ___domain and ITAM | journal = Biochemical and Biophysical Research Communications | volume = 225 | issue = 3 | pages = 1035–9 | date = August 1996 | pmid = 8780729 | doi = 10.1006/bbrc.1996.1290 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STAM signal transducing adaptor molecule (SH3 ___domain and ITAM motif) 1| url = httphttps://www.ncbi.nlm.nih.gov/sites/entrezgene?Db=gene&Cmd=ShowDetailView&TermToSearch=8027| accessdate = }}</ref>

== Function ==

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{{PBB_Summary

| section_title =

| summary_text = This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains an SH3 ___domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS (hepatocyte growth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein.<ref name="entrez">{{cite web | title = Entrez Gene: STAM signal transducing adaptor molecule (SH3 ___domain and ITAM motif) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8027| accessdate = }}</ref>

}}

| summary_text = This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains an [[SH3 ___domain]] and the [[immunoreceptor tyrosine-based activation motif]] (ITAM). This protein associates with [[JAK3]] and [[JAK2]] kinases via its ITAM region, and is phosphorylated by the [[JAK kinaseskinase]]s upon [[cytokine]] stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of [[cytokine receptors]]. HGS/HRS (hepatocyte growth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein.<ref name="entrez" />{{cite webSTAM1 | titlecontains =multiple Entrez[[amino Gene:acid]] STAMsites signalthat transducingare adaptor[[phosphorylated]] moleculeand (SH3[[ubiquitinated]].<ref>{{Cite ___domainweb|title=STAM1 and ITAM motif(human) 1| url = httphttps://www.ncbiphosphosite.nlmorg/proteinAction.nih.gov/sites/entrezaction?Dbid=gene6864&CmdshowAllSites=ShowDetailView&TermToSearchtrue|access-date=80272020-10-31| accessdate website= www.phosphosite.org}}</ref>

==References==

== Interactions ==

Signal transducing adaptor molecule has been shown to [[Protein-protein interaction|interact]] with

* [[HGS (gene)|HGS]],<ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}</ref><ref name=pmid9407053>{{cite journal | vauthors = Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, Takeshita T, Endo Y, Fujita T, Sugamura K | title = Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth | journal = The Journal of Biological Chemistry | volume = 272 | issue = 52 | pages = 32785–91 | date = December 1997 | pmid = 9407053 | doi = 10.1074/jbc.272.52.32785 | doi-access = free }}</ref><ref name=pmid12551915>{{cite journal | vauthors = Bache KG, Raiborg C, Mehlum A, Stenmark H | title = STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 14 | pages = 12513–21 | date = April 2003 | pmid = 12551915 | doi = 10.1074/jbc.M210843200 | doi-access = free }}</ref>

* [[Janus kinase 2]].<ref name=pmid9133424>{{cite journal | vauthors = Takeshita T, Arita T, Higuchi M, Asao H, Endo K, Kuroda H, Tanaka N, Murata K, Ishii N, Sugamura K | title = STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction | journal = Immunity | volume = 6 | issue = 4 | pages = 449–57 | date = April 1997 | pmid = 9133424 | doi = 10.1016/S1074-7613(00)80288-5 | doi-access = free }}</ref>

*[[MAP3K1]],<ref>{{cite journal | vauthors = Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E | title = The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines | journal = The EMBO Journal | volume = 33 | issue = 21 | pages = 2581–96 | date = November 2014 | pmid = 25260751 | pmc = 4282369 | doi = 10.15252/embj.201488351 }}</ref>

* [[STAMBP]],<ref name=pmid10982817>{{cite journal | vauthors = Kato M, Miyazawa K, Kitamura N | title = A deubiquitinating enzyme UBPY interacts with the Src homology 3 ___domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP | journal = The Journal of Biological Chemistry | volume = 275 | issue = 48 | pages = 37481–7 | date = December 2000 | pmid = 10982817 | doi = 10.1074/jbc.M007251200 | doi-access = free }}</ref><ref name=pmid10383417>{{cite journal | vauthors = Tanaka N, Kaneko K, Asao H, Kasai H, Endo Y, Fujita T, Takeshita T, Sugamura K | title = Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines | journal = The Journal of Biological Chemistry | volume = 274 | issue = 27 | pages = 19129–35 | date = July 1999 | pmid = 10383417 | doi = 10.1074/jbc.274.27.19129 | doi-access = free }}</ref> and

* [[TIMM8A]].<ref name=pmid12745081>{{cite journal | vauthors = Blackstone C, Roberts RG, Seeburg DP, Sheng M | title = Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1 | journal = Biochemical and Biophysical Research Communications | volume = 305 | issue = 2 | pages = 345–52 | date = May 2003 | pmid = 12745081 | doi = 10.1016/S0006-291X(03)00767-8 }}</ref>

== References ==

{{reflist}}

== Further reading ==

{{refbegin | 2}}

* {{cite journal | vauthors = Takeshita T, Arita T, Higuchi M, Asao H, Endo K, Kuroda H, Tanaka N, Murata K, Ishii N, Sugamura K | title = STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction | journal = Immunity | volume = 6 | issue = 4 | pages = 449–57 | date = April 1997 | pmid = 9133424 | doi = 10.1016/S1074-7613(00)80288-5 | doi-access = free }}

{{PBB_Further_reading

* {{cite journal | vauthors = Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, Takeshita T, Endo Y, Fujita T, Sugamura K | title = Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth | journal = The Journal of Biological Chemistry | volume = 272 | issue = 52 | pages = 32785–91 | date = December 1997 | pmid = 9407053 | doi = 10.1074/jbc.272.52.32785 | doi-access = free }}

| citations =

* {{cite journal | authorvauthors =Takeshita TTanaka N, AritaKaneko TK, Asao H, ''etKasai al.''H, Endo Y, Fujita T, Takeshita T, Sugamura K | title =Cloning Possible involvement of a novel signalSTAM-transducing adaptorassociated molecule containing"AMSH" anin SH3intracellular ___domainsignal andtransduction ITAM.mediated by cytokines | journal =Biochem. Biophys.The Res.Journal Commun.of Biological Chemistry | volume =225 274 | issue = 327 | pages = 1035–919129–35 |year date = 1996July 1999 | pmid = 878072910383417 | doi = 10.10061074/bbrcjbc.1996274.129027.19129 | doi-access = free }}

* {{cite journal | authorvauthors = Endo K, Takeshita T, AritaKasai TH, Sasaki Y, Tanaka N, Asao H, Kikuchi K, HiguchiYamada M, ''etChenb al.'M, O'Shea JJ, Sugamura K | title =STAM STAM2, signala transducingnew adaptormember of the STAM moleculefamily, isbinding associatedto withthe Janus kinases and| involvedjournal in= signalingFEBS forLetters cell| growthvolume and= c-myc induction.477 |journal issue =Immunity 1–2 |volume pages =6 55–61 |issue date = 4July 2000 |pages pmid = 449–5710899310 |year doi = 199710.1016/S0014-5793(00)01760-9 |pmid s2cid = 913342431811757 | doi-access = }}

* {{cite journal | authorvauthors =Asao H,Kato Sasaki YM, AritaMiyazawa TK, ''etKitamura al.''N | title =Hrs isA associateddeubiquitinating withenzyme STAM,UBPY ainteracts signal-transducingwith adaptorthe molecule.Src Itshomology suppressive3 effect___domain onof cytokineHrs-inducedbinding cellprotein growth.via a novel binding motif PX(V/I)(D/N)RXXKP | journal =J. Biol.The Chem.Journal of Biological Chemistry | volume =272 275 | issue = 5248 | pages = 32785–9137481–7 |year date = 1998December 2000 | pmid = 940705310982817 | doi = 10.1074/jbc.M007251200 | doi-access = free }}

* {{cite journal | authorvauthors =Tanaka NPandey A, KanekoFernandez KMM, AsaoSteen H, ''etBlagoev al.''B, Nielsen MM, Roche S, Mann M, Lodish HF | title =Possible involvementIdentification of a novel STAMimmunoreceptor tyrosine-associatedbased activation motif-containing molecule, "AMSH"STAM2, by mass spectrometry and its involvement in intracellulargrowth signalfactor transductionand mediatedcytokine byreceptor cytokines.signaling pathways | journal =J. Biol.The Chem.Journal of Biological Chemistry | volume =274 275 | issue = 2749 | pages = 19129–3538633–9 |year date = 1999December 2000 | pmid = 1038341710993906 | doi = 10.1074/jbc.M007849200 | doi-access = free }}

* {{cite journal | authorvauthors =Endo KSteen H, TakeshitaKuster TB, KasaiFernandez HM, ''etPandey al.''A, Mann M | title =STAM2, aTyrosine newphosphorylation membermapping of the STAMepidermal family,growth bindingfactor toreceptor thesignaling Januspathway kinases.| |journal =FEBS Lett.The Journal of Biological Chemistry | volume =477 277 | issue = 1-2 | pages = 55–611031–9 |year date = 2000January 2002 | pmid = 1089931011687594 | doi = 10.1074/jbc.M109992200 | doi-access = free }}

* {{cite journal | authorvauthors =Kato MBache KG, MiyazawaRaiborg KC, KitamuraMehlum N |title=A, deubiquitinatingStenmark enzymeH UBPY| interactstitle with= theSTAM Srcand homologyHrs 3are ___domainsubunits of Hrs-binding protein via a novelmultivalent ubiquitin-binding motifcomplex PX(V/I)(D/N)RXXKP.on early endosomes | journal =J. Biol.The Chem.Journal of Biological Chemistry | volume =275 278 | issue = 4814 | pages = 37481–712513–21 |year date = 2001April 2003 | pmid = 1098281712551915 | doi = 10.1074/jbc.M210843200 | doi-access = M007251200free }}

* {{cite journal | authorvauthors =Pandey ABlackstone C, FernandezRoberts MMRG, SteenSeeburg HDP, ''etSheng al.''M | title =Identification Interaction of athe novel immunoreceptor tyrosinedeafness-baseddystonia activationprotein motif-containingDDP/TIMM8a molecule,with STAM2,the bysignal masstransduction spectrometryadaptor andmolecule itsSTAM1 involvement| injournal growth= factorBiochemical and cytokineBiophysical receptorResearch signaling pathways.Communications |journal=J. Biol.volume Chem.= 305 |volume=275 |issue = 492 | pages = 38633–9345–52 |year date = 2001May 2003 | pmid = 1099390612745081 | doi = 10.10741016/jbc. M007849200S0006-291X(03)00767-8 }}

* {{cite journal | authorvauthors =Steen HMizuno E, KusterKawahata BK, FernandezKato M, ''etKitamura al.''N, Komada M | title =Tyrosine phosphorylationSTAM mappingproteins ofbind ubiquitinated proteins on the epidermalearly growthendosome factorvia receptorthe signalingVHS pathway.___domain and ubiquitin-interacting motif | journal =J. Biol.Molecular Chem.Biology of the Cell | volume =277 14 | issue = 29 | pages = 1031–93675–89 |year date = 2002September 2003 | pmid = 1168759412972556 | pmc = 196559 | doi = 10.10741091/jbcmbc. M109992200E02-12-0823 }}

* {{cite journal | authorvauthors =Strausberg RLMizuno E, FeingoldKawahata EAK, GrouseOkamoto LHA, ''etKitamura al.''N, Komada M | title =Generation andAssociation initialwith analysisHrs ofis morerequired thanfor 15,000the full-lengthearly humanendosomal localization, stability, and mousefunction cDNAof sequences.STAM | journal =Proc. Natl.Journal Acad.of Sci. U.S.A.Biochemistry | volume =99 135 | issue = 263 | pages = 16899–903385–96 |year date = 2003March 2004 | pmid = 1247793215113837 | doi = 10.10731093/pnas.242603899jb/mvh046 | doi-access = free }}

* {{cite journal | authorvauthors =Bache KGColland F, Jacq X, Trouplin V, Mougin C, RaiborgGroizeleau C, MehlumHamburger A, StenmarkMeil HA, Wojcik J, Legrain P, Gauthier JM | title=STAM and= HrsFunctional areproteomics subunitsmapping of a multivalenthuman ubiquitin-bindingsignaling complex on early endosomes.pathway | journal =J. Biol.Genome Chem.Research | volume =278 14 | issue = 147 | pages = 12513–211324–32 |year date = 2003July 2004 | pmid = 1255191515231748 | pmc = 442148 | doi = 10.10741101/jbcgr. M2108432002334104 }}

* {{cite journal | authorvauthors =Blackstone CKobayashi H, RobertsTanaka RGN, SeeburgAsao DPH, ShengMiura S, Kyuuma M, Semura K, Ishii N, Sugamura K | title =Interaction ofHrs, thea deafness-dystoniamammalian master molecule in vesicular transport and protein DDP/TIMM8asorting, withsuppresses the degradation of ESCRT proteins signal transductiontransducing adaptor molecule STAM1.1 and 2 | journal =Biochem. Biophys.The Res.Journal Commun.of Biological Chemistry | volume =305 280 | issue = 211 | pages = 345–5210468–77 |year date = 2003March 2005 | pmid = 1274508115640163 | doi = 10.1074/jbc.M409969200 | doi-access = free }}

* {{cite journal | authorvauthors =Mizuno E,Row Kawahata KPE, KatoClague MMJ, ''etUrbé al.''S | title =STAM proteinsGrowth factors induce binddifferential ubiquitinatedphosphorylation proteinsprofiles onof the earlyHrs-STAM endosomecomplex: viaa thecommon node in VHSsignalling ___domainnetworks andwith ubiquitinsignal-interactingspecific motif.properties | journal =Mol. Biol.The Biochemical CellJournal | volume =14 389 | issue = 9Pt 3 | pages = 3675–89629–36 |year date = 2004August 2005 | pmid = 1297255615828871 | pmc = 1180712 | doi = 10.10911042/mbc. E02-12-0823BJ20050067 }}

* {{cite journal | authorvauthors =Ota TZhang Y, SuzukiWolf-Yadlin YA, NishikawaRoss TPL, ''etPappin al.''DJ, Rush J, Lauffenburger DA, White FM | title =Complete sequencingTime-resolved andmass characterizationspectrometry of 21,243tyrosine full-lengthphosphorylation humansites cDNAs.in the epidermal growth factor receptor signaling network reveals dynamic modules | journal =Nat. Genet.Molecular & Cellular Proteomics | volume =36 4 | issue = 19 | pages = 40–51240–50 |year date = 2004September 2005 | pmid = 1470203915951569 | doi = 10.10381074/ng1285mcp.M500089-MCP200 | doi-access = free }}

* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}

*{{cite journal | author=Mizuno E, Kawahata K, Okamoto A, ''et al.'' |title=Association with Hrs is required for the early endosomal localization, stability, and function of STAM. |journal=J. Biochem. |volume=135 |issue= 3 |pages= 385–96 |year= 2005 |pmid= 15113837 |doi= }}

*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}

*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}

*{{cite journal | author=Kobayashi H, Tanaka N, Asao H, ''et al.'' |title=Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2. |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10468–77 |year= 2005 |pmid= 15640163 |doi= 10.1074/jbc. M409969200 }}

*{{cite journal | author=Row PE, Clague MJ, Urbé S |title=Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties. |journal=Biochem. J. |volume=389 |issue= Pt 3 |pages= 629–36 |year= 2005 |pmid= 15828871 |doi= 10.1042/BJ20050067 }}

*{{cite journal | author=Zhang Y, Wolf-Yadlin A, Ross PL, ''et al.'' |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp. M500089-MCP200 }}

*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}

}}

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