Signal transducing adaptor molecule: Difference between revisions

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{{Short description|Protein-coding gene in the species Homo sapiens}}

{{PBB|geneid=8027}}

{{Infobox_gene}}

'''Signal transducing adapter molecule 1''' is a [[protein]] that in humans is encoded by the ''STAM'' [[gene]].<ref name="pmid8780729">{{cite journal | authorvauthors = Takeshita T, Arita T, Asao H, Tanaka N, Higuchi M, Kuroda H, Kaneko K, Munakata H, Endo Y, Fujita T, Sugamura K | title = Cloning of a novel signal-transducing adaptor molecule containing an SH3 ___domain and ITAM | journal = BiochemBiochemical Biophysand Biophysical ResResearch CommunCommunications | volume = 225 | issue = 3 | pages = 1035–9 | yeardate = August 1996 | month = Oct | pmid = 8780729 | pmc = | doi = 10.1006/bbrc.1996.1290 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STAM signal transducing adaptor molecule (SH3 ___domain and ITAM motif) 1| url = httphttps://www.ncbi.nlm.nih.gov/sites/entrezgene?Db=gene&Cmd=ShowDetailView&TermToSearch=8027| accessdate = }}</ref>

== Function ==

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{{PBB_Summary

| section_title =

| summary_text = This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains an SH3 ___domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS (hepatocyte growth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein.<ref name="entrez">{{cite web | title = Entrez Gene: STAM signal transducing adaptor molecule (SH3 ___domain and ITAM motif) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8027| accessdate = }}</ref>

}}

| summary_text = This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains an [[SH3 ___domain]] and the [[immunoreceptor tyrosine-based activation motif]] (ITAM). This protein associates with [[JAK3]] and [[JAK2]] kinases via its ITAM region, and is phosphorylated by the [[JAK kinaseskinase]]s upon [[cytokine]] stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of [[cytokine receptors]]. HGS/HRS (hepatocyte growth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein.<ref name="entrez" />{{cite webSTAM1 | titlecontains =multiple Entrez[[amino Gene:acid]] STAMsites signalthat transducingare adaptor[[phosphorylated]] moleculeand (SH3[[ubiquitinated]].<ref>{{Cite ___domainweb|title=STAM1 and ITAM motif(human) 1| url = httphttps://www.ncbiphosphosite.nlmorg/proteinAction.nih.gov/sites/entrezaction?Dbid=gene6864&CmdshowAllSites=ShowDetailView&TermToSearchtrue|access-date=80272020-10-31| accessdate website= www.phosphosite.org}}</ref>

==Interactions==

Signal transducing adaptor molecule has been shown to [[Protein-protein_interaction|interact]] with [[STAMBP]],<ref name=pmid10982817>{{cite journal |last=Kato |first=M |authorlink= |coauthors=Miyazawa K, Kitamura N |year=[[2000]]|month=Dec. |title=A deubiquitinating enzyme UBPY interacts with the Src homology 3 ___domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP |journal=J. Biol. Chem. |volume=275 |issue=48 |pages=37481–7 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 10982817 |doi = 10.1074/jbc.M007251200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10383417>{{cite journal |last=Tanaka |first=N |authorlink= |coauthors=Kaneko K, Asao H, Kasai H, Endo Y, Fujita T, Takeshita T, Sugamura K |year=[[1999]]|month=Jul. |title=Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines |journal=J. Biol. Chem. |volume=274 |issue=27 |pages=19129–35 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 10383417 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.274.27.19129 }}</ref> [[HGS (gene)|HGS]],<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |authorlink= |coauthors=Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc |year=[[2005]]|month=Oct. |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |___location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid9407053>{{cite journal |last=Asao |first=H |authorlink= |coauthors=Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, Takeshita T, Endo Y, Fujita T, Sugamura K |year=[[1997]]|month=Dec. |title=Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth |journal=J. Biol. Chem. |volume=272 |issue=52 |pages=32785–91 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 9407053 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.272.52.32785 }}</ref><ref name=pmid12551915>{{cite journal |last=Bache |first=Kristi G |authorlink= |coauthors=Raiborg Camilla, Mehlum Anja, Stenmark Harald |year=[[2003]]|month=Apr. |title=STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes |journal=J. Biol. Chem. |volume=278 |issue=14 |pages=12513–21 |publisher= |___location = United States| issn = 0021-9258| pmid = 12551915 |doi = 10.1074/jbc.M210843200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[TIMM8A]]<ref name=pmid12745081>{{cite journal |last=Blackstone |first=Craig |authorlink= |coauthors=Roberts Roland G, Seeburg Daniel P, Sheng Morgan |year=[[2003]]|month=May. |title=Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1 |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue=2 |pages=345–52 |publisher= |___location = United States| issn = 0006-291X| pmid = 12745081 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0006-291X(03)00767-8 }}</ref> and [[Janus kinase 2]].<ref name=pmid9133424>{{cite journal |last=Takeshita |first=T |authorlink= |coauthors=Arita T, Higuchi M, Asao H, Endo K, Kuroda H, Tanaka N, Murata K, Ishii N, Sugamura K |year=[[1997]]|month=Apr. |title=STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction |journal=Immunity |volume=6 |issue=4 |pages=449–57 |publisher= |___location = UNITED STATES| issn = 1074-7613| pmid = 9133424 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S1074-7613(00)80288-5 }}</ref>

==References Interactions ==

Signal transducing adaptor molecule has been shown to [[Protein-protein interaction|interact]] with

* [[HGS (gene)|HGS]],<ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}</ref><ref name=pmid9407053>{{cite journal | vauthors = Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, Takeshita T, Endo Y, Fujita T, Sugamura K | title = Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth | journal = The Journal of Biological Chemistry | volume = 272 | issue = 52 | pages = 32785–91 | date = December 1997 | pmid = 9407053 | doi = 10.1074/jbc.272.52.32785 | doi-access = free }}</ref><ref name=pmid12551915>{{cite journal | vauthors = Bache KG, Raiborg C, Mehlum A, Stenmark H | title = STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 14 | pages = 12513–21 | date = April 2003 | pmid = 12551915 | doi = 10.1074/jbc.M210843200 | doi-access = free }}</ref>

* [[Janus kinase 2]].<ref name=pmid9133424>{{cite journal | vauthors = Takeshita T, Arita T, Higuchi M, Asao H, Endo K, Kuroda H, Tanaka N, Murata K, Ishii N, Sugamura K | title = STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction | journal = Immunity | volume = 6 | issue = 4 | pages = 449–57 | date = April 1997 | pmid = 9133424 | doi = 10.1016/S1074-7613(00)80288-5 | doi-access = free }}</ref>

*[[MAP3K1]],<ref>{{cite journal | vauthors = Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E | title = The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines | journal = The EMBO Journal | volume = 33 | issue = 21 | pages = 2581–96 | date = November 2014 | pmid = 25260751 | pmc = 4282369 | doi = 10.15252/embj.201488351 }}</ref>

* [[STAMBP]],<ref name=pmid10982817>{{cite journal | vauthors = Kato M, Miyazawa K, Kitamura N | title = A deubiquitinating enzyme UBPY interacts with the Src homology 3 ___domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP | journal = The Journal of Biological Chemistry | volume = 275 | issue = 48 | pages = 37481–7 | date = December 2000 | pmid = 10982817 | doi = 10.1074/jbc.M007251200 | doi-access = free }}</ref><ref name=pmid10383417>{{cite journal | vauthors = Tanaka N, Kaneko K, Asao H, Kasai H, Endo Y, Fujita T, Takeshita T, Sugamura K | title = Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines | journal = The Journal of Biological Chemistry | volume = 274 | issue = 27 | pages = 19129–35 | date = July 1999 | pmid = 10383417 | doi = 10.1074/jbc.274.27.19129 | doi-access = free }}</ref> and

* [[TIMM8A]].<ref name=pmid12745081>{{cite journal | vauthors = Blackstone C, Roberts RG, Seeburg DP, Sheng M | title = Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1 | journal = Biochemical and Biophysical Research Communications | volume = 305 | issue = 2 | pages = 345–52 | date = May 2003 | pmid = 12745081 | doi = 10.1016/S0006-291X(03)00767-8 }}</ref>

== References ==

{{reflist}}

== Further reading ==

{{refbegin | 2}}

* {{cite journal | vauthors = Takeshita T, Arita T, Higuchi M, Asao H, Endo K, Kuroda H, Tanaka N, Murata K, Ishii N, Sugamura K | title = STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction | journal = Immunity | volume = 6 | issue = 4 | pages = 449–57 | date = April 1997 | pmid = 9133424 | doi = 10.1016/S1074-7613(00)80288-5 | doi-access = free }}

{{PBB_Further_reading

* {{cite journal | vauthors = Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, Takeshita T, Endo Y, Fujita T, Sugamura K | title = Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth | journal = The Journal of Biological Chemistry | volume = 272 | issue = 52 | pages = 32785–91 | date = December 1997 | pmid = 9407053 | doi = 10.1074/jbc.272.52.32785 | doi-access = free }}

| citations =

* {{cite journal | authorvauthors =Takeshita TTanaka N, AritaKaneko TK, HiguchiAsao MH, ''etKasai al.''H, |title=STAMEndo Y, signalFujita transducingT, adaptorTakeshita moleculeT, isSugamura associatedK with| Janustitle kinases= andPossible involvedinvolvement inof signalinga fornovel cellSTAM-associated growthmolecule and"AMSH" c-mycin induction.intracellular signal transduction mediated by cytokines | journal =Immunity The Journal of Biological Chemistry | volume =6 274 | issue = 427 | pages = 449–5719129–35 |year date = 1997July 1999 | pmid = 913342410383417 | doi = 10.10161074/S1074jbc.274.27.19129 | doi-7613(00)80288-5access = free }}

* {{cite journal | authorvauthors =Asao Endo K, Takeshita T, Kasai H, Sasaki Y, AritaTanaka TN, ''etAsao al.'H, Kikuchi K, Yamada M, Chenb M, O'Shea |title=HrsJJ, isSugamura associatedK with| STAMtitle = STAM2, a signal-transducingnew adaptormember molecule.of Itsthe suppressiveSTAM effectfamily, onbinding cytokine-inducedto cellthe growth.Janus kinases | journal =J. Biol.FEBS Chem.Letters | volume =272 477 | issue = 521–2 | pages = 32785–9155–61 |year date = 1998July 2000 | pmid = 940705310899310 | doi = 10.10741016/jbc.272.52.32785S0014-5793(00)01760-9 | s2cid = 31811757 | doi-access = }}

* {{cite journal | authorvauthors =Tanaka NKato M, KanekoMiyazawa K, AsaoKitamura H,N ''et al.''| |title =Possible involvementA ofdeubiquitinating aenzyme novelUBPY STAM-associatedinteracts moleculewith "AMSH"the inSrc intracellularhomology signal3 transduction___domain mediatedof byHrs-binding cytokines.protein via a novel binding motif PX(V/I)(D/N)RXXKP | journal =J. Biol.The Chem.Journal of Biological Chemistry | volume =274 275 | issue = 2748 | pages = 19129–3537481–7 |year date = 1999December 2000 | pmid = 1038341710982817 | doi = 10.1074/jbc.274.27.19129M007251200 | doi-access = free }}

* {{cite journal | authorvauthors =Endo KPandey A, TakeshitaFernandez TMM, KasaiSteen H, ''etBlagoev al.''B, Nielsen MM, Roche S, Mann M, Lodish HF | title =STAM2, Identification of a newnovel memberimmunoreceptor oftyrosine-based theactivation STAMmotif-containing familymolecule, bindingSTAM2, toby themass Janusspectrometry kinases.and its involvement in growth factor and cytokine receptor signaling pathways | journal =FEBS Lett.The Journal of Biological Chemistry | volume =477 275 | issue = 1-249 | pages = 55–6138633–9 |year date = December 2000 | pmid = 1089931010993906 | doi = 10.10161074/S0014jbc.M007849200 | doi-5793(00)01760-9access = free }}

* {{cite journal | authorvauthors =Kato MSteen H, MiyazawaKuster KB, KitamuraFernandez NM, Pandey |title=A, deubiquitinatingMann enzymeM UBPY| interactstitle with the Src= homologyTyrosine 3phosphorylation ___domainmapping of Hrs-bindingthe proteinepidermal viagrowth afactor novelreceptor bindingsignaling motifpathway PX(V/I)(D/N)RXXKP.| |journal =J. Biol.The Chem.Journal of Biological Chemistry | volume =275 277 | issue = 482 | pages = 37481–71031–9 |year date = 2001January 2002 | pmid = 1098281711687594 | doi = 10.1074/jbc.M109992200 | doi-access = free }}

* {{cite journal | authorvauthors =Pandey ABache KG, FernandezRaiborg MMC, SteenMehlum HA, ''etStenmark al.''H | title =Identification ofSTAM aand novelHrs immunoreceptorare tyrosine-basedsubunits activationof motif-containinga molecule,multivalent STAM2,ubiquitin-binding bycomplex masson spectrometryearly andendosomes its| involvementjournal in= growthThe factorJournal andof cytokineBiological receptorChemistry signaling| pathways.volume |journal=J. Biol. Chem.278 |volume=275 |issue = 4914 | pages = 38633–912513–21 |year date = 2001April 2003 | pmid = 1099390612551915 | doi = 10.1074/jbc.M210843200 | doi-access = free }}

* {{cite journal | authorvauthors =Steen HBlackstone C, KusterRoberts BRG, FernandezSeeburg MDP, ''etSheng al.''M | title=Tyrosine phosphorylation= mappingInteraction of the epidermaldeafness-dystonia growthprotein factorDDP/TIMM8a receptorwith signalingthe pathway.signal transduction adaptor molecule STAM1 | journal =J. Biol.Biochemical Chem.and Biophysical Research Communications | volume =277 305 | issue = 2 | pages = 1031–9345–52 |year date = 2002May 2003 | pmid = 1168759412745081 | doi = 10.10741016/jbc.S0006-291X(03)00767-8 }}

* {{cite journal | authorvauthors =Strausberg RLMizuno E, FeingoldKawahata EAK, GrouseKato LHM, ''etKitamura al.''N, Komada M | title =Generation andSTAM initialproteins analysisbind ofubiquitinated moreproteins thanon 15,000the full-lengthearly humanendosome andvia mousethe cDNAVHS sequences.___domain and ubiquitin-interacting motif | journal =Proc. Natl.Molecular Acad.Biology Sci.of U.S.A.the Cell | volume =99 14 | issue = 269 | pages = 16899–9033675–89 |year date = September 2003 | pmid = 1247793212972556 | pmc = 196559 | doi = 10.10731091/pnasmbc.242603899 | pmc=139241E02-12-0823 }}

* {{cite journal | authorvauthors =Bache KGMizuno E, RaiborgKawahata CK, MehlumOkamoto A, StenmarkKitamura HN, Komada M | title =STAM andAssociation with Hrs areis subunitsrequired offor athe multivalentearly ubiquitin-bindingendosomal complexlocalization, onstability, earlyand endosomes.function of STAM | journal =J. Biol.Journal Chem.of Biochemistry | volume =278 135 | issue = 143 | pages = 12513–21385–96 |year date = 2003March 2004 | pmid = 1255191515113837 | doi = 10.10741093/jbc.jb/mvh046 | doi-access = free }}

* {{cite journal | authorvauthors =Blackstone Colland F, Jacq X, Trouplin V, Mougin C, RobertsGroizeleau RGC, SeeburgHamburger DPA, ShengMeil MA, |title=InteractionWojcik ofJ, theLegrain deafness-dystoniaP, proteinGauthier DDP/TIMM8aJM with| thetitle signal= transductionFunctional adaptorproteomics moleculemapping STAM1.of a human signaling pathway | journal =Biochem. Biophys.Genome Res. Commun.Research | volume =305 14 | issue = 27 | pages = 345–521324–32 |year date = 2003July 2004 | pmid = 1274508115231748 | pmc = 442148 | doi = 10.10161101/S0006-291X(03)00767-8 gr.2334104 }}

* {{cite journal | authorvauthors =Mizuno EKobayashi H, KawahataTanaka KN, KatoAsao H, Miura S, Kyuuma M, ''etSemura al.''K, Ishii N, Sugamura K | title =STAM proteinsHrs, binda ubiquitinatedmammalian proteinsmaster onmolecule thein earlyvesicular endosometransport viaand protein sorting, suppresses the VHSdegradation ___domainof andESCRT ubiquitin-interactingproteins motif.signal transducing adaptor molecule 1 and 2 | journal =Mol. Biol.The Journal of Biological CellChemistry | volume =14 280 | issue = 911 | pages = 3675–8910468–77 |year date = 2004March 2005 | pmid = 1297255615640163 | doi = 10.10911074/mbcjbc. M409969200 | pmcdoi-access =196559 free }}

* {{cite journal | authorvauthors =Ota T, SuzukiRow YPE, NishikawaClague TMJ, ''etUrbé al.''S | title =Complete sequencingGrowth andfactors characterizationinduce differential phosphorylation profiles of 21,243the fullHrs-lengthSTAM humancomplex: cDNAs.a common node in signalling networks with signal-specific properties | journal =Nat. Genet.The Biochemical Journal | volume =36 389 | issue = 1Pt 3 | pages = 40–5629–36 |year date = 2004August 2005 | pmid = 1470203915828871 | pmc = 1180712 | doi = 10.10381042/ng1285BJ20050067 }}

* {{cite journal | authorvauthors =Mizuno EZhang Y, KawahataWolf-Yadlin KA, OkamotoRoss APL, ''etPappin al.''DJ, Rush J, Lauffenburger DA, White FM | title =Association withTime-resolved Hrsmass isspectrometry requiredof fortyrosine phosphorylation sites in the earlyepidermal endosomalgrowth localization,factor stability,receptor andsignaling functionnetwork ofreveals STAM.dynamic modules | journal =J. Biochem.Molecular & Cellular Proteomics | volume =135 4 | issue = 39 | pages = 385–961240–50 |year date = September 2005 | pmid = 1511383715951569 | doi = 10.10931074/jb/mvh046mcp.M500089-MCP200 | doi-access = free }}

* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}

*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}

*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}

*{{cite journal | author=Kobayashi H, Tanaka N, Asao H, ''et al.'' |title=Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2. |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10468–77 |year= 2005 |pmid= 15640163 |doi= 10.1074/jbc. }}

*{{cite journal | author=Row PE, Clague MJ, Urbé S |title=Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties. |journal=Biochem. J. |volume=389 |issue= Pt 3 |pages= 629–36 |year= 2005 |pmid= 15828871 |doi= 10.1042/BJ20050067 | pmc=1180712 }}

*{{cite journal | author=Zhang Y, Wolf-Yadlin A, Ross PL, ''et al.'' |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp. }}

*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}

}}

{{refend}}

{{gene-10-stub}}

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