Signal transducing adaptor molecule: Difference between revisions

Revision as of 21:58, 5 June 2016

Latest revision as of 15:34, 25 August 2025

(20 intermediate revisions by 10 users not shown)

Line 1:

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

'''Signal transducing adapter molecule 1''' is a [[protein]] that in humans is encoded by the ''STAM'' [[gene]].<ref name="pmid8780729">{{cite journal | vauthors = Takeshita T, Arita T, Asao H, Tanaka N, Higuchi M, Kuroda H, Kaneko K, Munakata H, Endo Y, Fujita T, Sugamura K | title = Cloning of a novel signal-transducing adaptor molecule containing an SH3 ___domain and ITAM | journal = BiochemBiochemical Biophysand Biophysical ResResearch CommunCommunications | volume = 225 | issue = 3 | pages = 1035–9 | date =October August 1996 | pmid = 8780729 | pmc = | doi = 10.1006/bbrc.1996.1290 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STAM signal transducing adaptor molecule (SH3 ___domain and ITAM motif) 1| url = httphttps://www.ncbi.nlm.nih.gov/sites/entrezgene?Db=gene&Cmd=ShowDetailView&TermToSearch=8027| accessdate = }}</ref>

== Function ==

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->

{{PBB_Summary

| section_title =

| summary_text = This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains an SH3 ___domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS (hepatocyte growth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein.<ref name="entrez" />

}}

| summary_text = This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains an [[SH3 ___domain]] and the [[immunoreceptor tyrosine-based activation motif]] (ITAM). This protein associates with [[JAK3]] and [[JAK2]] kinases via its ITAM region, and is phosphorylated by the [[JAK kinaseskinase]]s upon [[cytokine]] stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of [[cytokine receptors]]. HGS/HRS (hepatocyte growth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein.<ref name="entrez" /> STAM1 contains multiple [[amino acid]] sites that are [[phosphorylated]] and [[ubiquitinated]].<ref>{{Cite web|title=STAM1 (human)|url=https://www.phosphosite.org/proteinAction.action?id=6864&showAllSites=true|access-date=2020-10-31|website=www.phosphosite.org}}</ref>

==Interactions==

Signal transducing adaptor molecule has been shown to [[Protein-protein interaction|interact]] with [[STAMBP]],<ref name=pmid10982817>{{cite journal |last=Kato |first=M |authorlink= |author2=Miyazawa K |author3=Kitamura N |date=December 2000 |title=A deubiquitinating enzyme UBPY interacts with the Src homology 3 ___domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP |journal=J. Biol. Chem. |volume=275 |issue=48 |pages=37481–7 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 10982817 |doi = 10.1074/jbc.M007251200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10383417>{{cite journal |last=Tanaka |first=N |authorlink= |author2=Kaneko K |author3=Asao H |author4=Kasai H |author5=Endo Y |author6=Fujita T |author7=Takeshita T |author8=Sugamura K |date=July 1999 |title=Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines |journal=J. Biol. Chem. |volume=274 |issue=27 |pages=19129–35 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 10383417 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.274.27.19129 }}</ref> [[HGS (gene)|HGS]],<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |coauthors=Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc |date=October 2005 |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |___location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid9407053>{{cite journal |last=Asao |first=H |authorlink= |author2=Sasaki Y |author3=Arita T |author4=Tanaka N |author5=Endo K |author6=Kasai H |author7=Takeshita T |author8=Endo Y |author9=Fujita T |author10=Sugamura K |date=December 1997 |title=Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth |journal=J. Biol. Chem. |volume=272 |issue=52 |pages=32785–91 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 9407053 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.272.52.32785 }}</ref><ref name=pmid12551915>{{cite journal |last=Bache |first=Kristi G |authorlink= |author2=Raiborg Camilla |author3=Mehlum Anja |author4=Stenmark Harald |date=April 2003 |title=STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes |journal=J. Biol. Chem. |volume=278 |issue=14 |pages=12513–21 |publisher= |___location = United States| issn = 0021-9258| pmid = 12551915 |doi = 10.1074/jbc.M210843200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[TIMM8A]]<ref name=pmid12745081>{{cite journal |last=Blackstone |first=Craig |authorlink= |author2=Roberts Roland G |author3=Seeburg Daniel P |author4=Sheng Morgan |date=May 2003 |title=Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1 |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue=2 |pages=345–52 |publisher= |___location = United States| issn = 0006-291X| pmid = 12745081 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0006-291X(03)00767-8 }}</ref> and [[Janus kinase 2]].<ref name=pmid9133424>{{cite journal |last=Takeshita |first=T |authorlink= |author2=Arita T |author3=Higuchi M |author4=Asao H |author5=Endo K |author6=Kuroda H |author7=Tanaka N |author8=Murata K |author9=Ishii N |author10=Sugamura K |date=April 1997 |title=STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction |journal=Immunity |volume=6 |issue=4 |pages=449–57 |publisher= |___location = UNITED STATES| issn = 1074-7613| pmid = 9133424 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S1074-7613(00)80288-5 }}</ref>

==References Interactions ==

Signal transducing adaptor molecule has been shown to [[Protein-protein interaction|interact]] with

* [[HGS (gene)|HGS]],<ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}</ref><ref name=pmid9407053>{{cite journal | vauthors = Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, Takeshita T, Endo Y, Fujita T, Sugamura K | title = Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth | journal = The Journal of Biological Chemistry | volume = 272 | issue = 52 | pages = 32785–91 | date = December 1997 | pmid = 9407053 | doi = 10.1074/jbc.272.52.32785 | doi-access = free }}</ref><ref name=pmid12551915>{{cite journal | vauthors = Bache KG, Raiborg C, Mehlum A, Stenmark H | title = STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 14 | pages = 12513–21 | date = April 2003 | pmid = 12551915 | doi = 10.1074/jbc.M210843200 | doi-access = free }}</ref>

* [[Janus kinase 2]].<ref name=pmid9133424>{{cite journal | vauthors = Takeshita T, Arita T, Higuchi M, Asao H, Endo K, Kuroda H, Tanaka N, Murata K, Ishii N, Sugamura K | title = STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction | journal = Immunity | volume = 6 | issue = 4 | pages = 449–57 | date = April 1997 | pmid = 9133424 | doi = 10.1016/S1074-7613(00)80288-5 | doi-access = free }}</ref>

*[[MAP3K1]],<ref>{{cite journal | vauthors = Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E | title = The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines | journal = The EMBO Journal | volume = 33 | issue = 21 | pages = 2581–96 | date = November 2014 | pmid = 25260751 | pmc = 4282369 | doi = 10.15252/embj.201488351 }}</ref>

* [[STAMBP]],<ref name=pmid10982817>{{cite journal | vauthors = Kato M, Miyazawa K, Kitamura N | title = A deubiquitinating enzyme UBPY interacts with the Src homology 3 ___domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP | journal = The Journal of Biological Chemistry | volume = 275 | issue = 48 | pages = 37481–7 | date = December 2000 | pmid = 10982817 | doi = 10.1074/jbc.M007251200 | doi-access = free }}</ref><ref name=pmid10383417>{{cite journal | vauthors = Tanaka N, Kaneko K, Asao H, Kasai H, Endo Y, Fujita T, Takeshita T, Sugamura K | title = Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines | journal = The Journal of Biological Chemistry | volume = 274 | issue = 27 | pages = 19129–35 | date = July 1999 | pmid = 10383417 | doi = 10.1074/jbc.274.27.19129 | doi-access = free }}</ref> and

* [[TIMM8A]].<ref name=pmid12745081>{{cite journal | vauthors = Blackstone C, Roberts RG, Seeburg DP, Sheng M | title = Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1 | journal = Biochemical and Biophysical Research Communications | volume = 305 | issue = 2 | pages = 345–52 | date = May 2003 | pmid = 12745081 | doi = 10.1016/S0006-291X(03)00767-8 }}</ref>

== References ==

{{reflist}}

== Further reading ==

{{refbegin | 2}}

* {{cite journal | vauthors = Takeshita T, Arita T, Higuchi M, Asao H, Endo K, Kuroda H, Tanaka N, Murata K, Ishii N, Sugamura K | title = STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction | journal = Immunity | volume = 6 | issue = 4 | pages = 449–57 | date = April 1997 | pmid = 9133424 | doi = 10.1016/S1074-7613(00)80288-5 | doi-access = free }}

{{PBB_Further_reading

* {{cite journal | vauthors = Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, Takeshita T, Endo Y, Fujita T, Sugamura K | title = Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth | journal = The Journal of Biological Chemistry | volume = 272 | issue = 52 | pages = 32785–91 | date = December 1997 | pmid = 9407053 | doi = 10.1074/jbc.272.52.32785 | doi-access = free }}

| citations =

* {{cite journal | vauthors =Takeshita TTanaka N, AritaKaneko TK, HiguchiAsao MH, etalKasai |title=STAMH, signalEndo transducingY, adaptorFujita moleculeT, isTakeshita associatedT, withSugamura JanusK kinases| andtitle involved= inPossible signalinginvolvement forof cella growthnovel and cSTAM-mycassociated inductionmolecule "AMSH" in intracellular signal transduction mediated by cytokines | journal =Immunity The Journal of Biological Chemistry | volume =6 274 | issue = 427 | pages = 449–5719129–35 |year date = 1997July 1999 | pmid = 913342410383417 | doi = 10.10161074/S1074jbc.274.27.19129 | doi-7613(00)80288-5access = free }}

* {{cite journal | vauthors =Asao Endo K, Takeshita T, Kasai H, Sasaki Y, AritaTanaka TN, etalAsao |title=HrsH, isKikuchi associatedK, withYamada STAMM, Chenb M, O'Shea JJ, Sugamura K | title = STAM2, a signal-transducingnew adaptormember molecule.of Itsthe suppressiveSTAM effectfamily, onbinding cytokine-inducedto cellthe growthJanus kinases | journal =J. Biol.FEBS Chem.Letters | volume =272 477 | issue = 521–2 | pages = 32785–9155–61 |year date = 1998July 2000 | pmid = 940705310899310 | doi = 10.10741016/jbc.272.52.32785S0014-5793(00)01760-9 | s2cid = 31811757 | doi-access = }}

* {{cite journal | vauthors =Tanaka NKato M, KanekoMiyazawa K, AsaoKitamura H,N etal| |title =Possible involvementA ofdeubiquitinating aenzyme novelUBPY STAM-associatedinteracts moleculewith "AMSH"the inSrc intracellularhomology signal3 transduction___domain mediatedof byHrs-binding cytokinesprotein via a novel binding motif PX(V/I)(D/N)RXXKP | journal =J. Biol.The Chem.Journal of Biological Chemistry | volume =274 275 | issue = 2748 | pages = 19129–3537481–7 |year date = 1999December 2000 | pmid = 1038341710982817 | doi = 10.1074/jbc.274.27.19129M007251200 | doi-access = free }}

* {{cite journal | vauthors =Endo KPandey A, TakeshitaFernandez TMM, KasaiSteen H, etalBlagoev B, Nielsen MM, Roche S, Mann M, Lodish HF | title =STAM2, Identification of a newnovel memberimmunoreceptor oftyrosine-based theactivation STAMmotif-containing familymolecule, bindingSTAM2, toby themass Janusspectrometry kinasesand its involvement in growth factor and cytokine receptor signaling pathways | journal =FEBS Lett.The Journal of Biological Chemistry | volume =477 275 | issue = 1–249 | pages = 55–6138633–9 |year date = December 2000 | pmid = 1089931010993906 | doi = 10.10161074/S0014jbc.M007849200 | doi-5793(00)01760-9access = free }}

* {{cite journal | vauthors =Kato MSteen H, MiyazawaKuster KB, KitamuraFernandez NM, Pandey |title=A, deubiquitinatingMann enzymeM UBPY| interactstitle with the= SrcTyrosine homologyphosphorylation 3 ___domainmapping of Hrs-bindingthe proteinepidermal viagrowth afactor novelreceptor bindingsignaling motifpathway PX(V/I)(D/N)RXXKP| |journal =J. Biol.The Chem.Journal of Biological Chemistry | volume =275 277 | issue = 482 | pages = 37481–71031–9 |year date = 2001January 2002 | pmid = 1098281711687594 | doi = 10.1074/jbc.M007251200M109992200 | doi-access = free }}

* {{cite journal | vauthors =Pandey ABache KG, FernandezRaiborg MMC, SteenMehlum HA, etalStenmark H | title =Identification ofSTAM aand novelHrs immunoreceptorare tyrosine-basedsubunits activationof motif-containinga molecule,multivalent STAM2,ubiquitin-binding bycomplex masson spectrometryearly andendosomes its| involvementjournal in= growthThe factorJournal andof cytokineBiological receptorChemistry signaling| pathwaysvolume |journal=J. Biol. Chem.278 |volume=275 |issue = 4914 | pages = 38633–912513–21 |year date = 2001April 2003 | pmid = 1099390612551915 | doi = 10.1074/jbc.M007849200M210843200 | doi-access = free }}

* {{cite journal | vauthors = Blackstone C, Roberts RG, Seeburg DP, Sheng M | title = Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1 | journal = Biochemical and Biophysical Research Communications | volume = 305 | issue = 2 | pages = 345–52 | date = May 2003 | pmid = 12745081 | doi = 10.1016/S0006-291X(03)00767-8 }}

}}

* {{cite journal | vauthors =Steen HMizuno E, KusterKawahata BK, FernandezKato M, etalKitamura N, Komada M | title =Tyrosine phosphorylationSTAM mappingproteins ofbind ubiquitinated proteins on the epidermalearly endosome via the growthVHS factor___domain receptorand signalingubiquitin-interacting pathwaymotif | journal =J. Biol.Molecular Chem.Biology of the Cell | volume =277 14 | issue = 29 | pages = 1031–93675–89 |year date = 2002September 2003 | pmid = 1168759412972556 | pmc = 196559 | doi = 10.10741091/jbcmbc.M109992200 E02-12-0823 }}

* {{cite journal | vauthors =Strausberg RLMizuno E, FeingoldKawahata EAK, GrouseOkamoto LHA, etalKitamura N, Komada M | title =Generation andAssociation initialwith analysisHrs ofis morerequired thanfor 15,000the full-lengthearly humanendosomal localization, stability, and mousefunction cDNAof sequencesSTAM | journal =Proc. Natl.Journal Acad.of Sci. U.S.A.Biochemistry | volume =99 135 | issue = 263 | pages = 16899–903385–96 |year date = 2003March 2004 | pmid = 1247793215113837 | doi = 10.10731093/pnas.242603899 jb/mvh046 | pmcdoi-access =139241 free }}

* {{cite journal | vauthors =Bache KGColland F, Jacq X, Trouplin V, Mougin C, RaiborgGroizeleau C, MehlumHamburger A, StenmarkMeil HA, Wojcik J, Legrain P, Gauthier JM | title=STAM and= HrsFunctional areproteomics subunitsmapping of a multivalenthuman ubiquitin-bindingsignaling complex on early endosomespathway | journal =J. Biol.Genome Chem.Research | volume =278 14 | issue = 147 | pages = 12513–211324–32 |year date = 2003July 2004 | pmid = 1255191515231748 | pmc = 442148 | doi = 10.10741101/jbcgr.M210843200 2334104 }}

* {{cite journal | vauthors =Blackstone CKobayashi H, RobertsTanaka RGN, SeeburgAsao DPH, ShengMiura S, Kyuuma M, Semura K, Ishii N, Sugamura K | title =Interaction ofHrs, thea deafness-dystoniamammalian master molecule in vesicular transport and protein DDP/TIMM8asorting, withsuppresses the degradation of ESCRT proteins signal transductiontransducing adaptor molecule STAM11 and 2 | journal =Biochem. Biophys.The Res.Journal Commun.of Biological Chemistry | volume =305 280 | issue = 211 | pages = 345–5210468–77 |year date = 2003March 2005 | pmid = 1274508115640163 | doi = 10.10161074/S0006jbc.M409969200 | doi-291X(03)00767-8access = free }}

* {{cite journal | vauthors =Mizuno E,Row Kawahata KPE, KatoClague MMJ, etalUrbé S | title =STAM proteinsGrowth bindfactors ubiquitinatedinduce proteinsdifferential onphosphorylation profiles of the earlyHrs-STAM endosomecomplex: viaa thecommon node in VHSsignalling ___domainnetworks andwith ubiquitinsignal-interactingspecific motifproperties | journal =Mol. Biol.The CellBiochemical Journal | volume =14 389 | issue = 9Pt 3 | pages = 3675–89629–36 |year date = 2004August 2005 | pmid = 1297255615828871 | pmc = 1180712 | doi = 10.10911042/mbc.E02-12-0823| pmc=196559BJ20050067 }}

* {{cite journal | vauthors =Ota TZhang Y, SuzukiWolf-Yadlin YA, NishikawaRoss TPL, etalPappin DJ, Rush J, Lauffenburger DA, White FM | title =Complete sequencingTime-resolved andmass characterizationspectrometry of 21,243tyrosine full-lengthphosphorylation humansites cDNAsin the epidermal growth factor receptor signaling network reveals dynamic modules | journal =Nat. Genet.Molecular & Cellular Proteomics | volume =36 4 | issue = 19 | pages = 40–51240–50 |year date = 2004September 2005 | pmid = 1470203915951569 | doi = 10.10381074/ng1285mcp.M500089-MCP200 | doi-access = free }}

* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}

*{{cite journal |vauthors=Mizuno E, Kawahata K, Okamoto A, etal |title=Association with Hrs is required for the early endosomal localization, stability, and function of STAM |journal=J. Biochem. |volume=135 |issue= 3 |pages= 385–96 |year= 2005 |pmid= 15113837 |doi=10.1093/jb/mvh046 }}

*{{cite journal |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}

*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}

*{{cite journal |vauthors=Kobayashi H, Tanaka N, Asao H, etal |title=Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2 |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10468–77 |year= 2005 |pmid= 15640163 |doi=10.1074/jbc.M409969200 }}

*{{cite journal |vauthors=Row PE, Clague MJ, Urbé S |title=Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties |journal=Biochem. J. |volume=389 |issue= Pt 3 |pages= 629–36 |year= 2005 |pmid= 15828871 |doi= 10.1042/BJ20050067 | pmc=1180712 }}

*{{cite journal |vauthors=Zhang Y, Wolf-Yadlin A, Ross PL, etal |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules |journal=Mol. Cell Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 }}

*{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}

}}

{{refend}}

<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->

{{PBB_Controls

| update_page = yes

| require_manual_inspection = no

| update_protein_box = yes

| update_summary = yes

| update_citations = yes

}}