Gustavus Franklin Swift and Cannabis (drug): Difference between pages
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[[Image:Macro cannabis bud.jpg|thumb|200px|right|A dried flowered bud of the ''Cannabis sativa'' plant.]]
{{ wiktionarypar |marijuana}}
:''For the plant see [[Cannabis]].
'''Cannabis''' (also known as '''marijuana'''<ref>Random House Unabridged dictionary: marijuana, n. 1. hemp. 2. the dried leaves and female flowers of the hemp plant, used in cigarette form as a narcotic or hallucinogen. Also, marihuana. [1890-95, American < MexSp marihuana, mariguana]</ref> or '''ganja'''<ref>The [[Oxford English Dictionary]]: Any of various preparations of different parts of the hemp-plant which are smoked, chewed, sniffed or drunk for their intoxicating or hallucinogenic properties and were formerly used medicinally; bhang (marijuana), ganja, and charas (hashish) are different forms of these preparations." It is also notes that "cannabis" was elliptical reference (i.e. slang) for Cannabis sativa.</ref> in its herbal form and '''[[hashish]]''' in its [[resin]]ous form<ref>http://www.idmu.co.uk/can.htm</ref>) is a [[psychoactive drug|psychoactive]] product of the plant ''[[Cannabis sativa]]'' L. subsp. ''indica'' (= ''C. indica'' Lam.). The herbal form of the drug consists of dried mature [[inflorescence]]s and subtending leaves of pistillate ("female") plants. The resinous form consists primarily of glandular trichomes collected from the same plant material.
The major biologically active [[chemical compound]] in cannabis is Δ<sup>9</sup>-[[tetrahydrocannabinol]], commonly referred to as THC. It has [[Psychoactive drug|psychoactive]] and [[physiological]] effects when consumed, usually by smoking or ingestion. The minimum amount of THC required to have a perceptible psychoactive effect is about 5 mg. A related compound, Δ<sup>9</sup>-tetrahydrocannabidivarin, also known as THCV, is produced in appreciable amounts by certain drug strains. This [[cannabinoid]] has been described in the popular literature as having shorter-acting, flashier effects than THC, but recent studies suggest that it may actually inhibit the effects of THC. Relatively high levels of THCV are common in African dagga (marijuana), and in hashish from the northwest Himalayas.Humans have been consuming cannabis since prehistory{{Fact|date=May 2007}}, although in the 20th century there was a rise in its use for [[Recreational drug use|recreational]], [[religious]] or spiritual, and medicinal purposes. It is estimated that cannabis is now regularly used by four percent of the world's adult population,<ref name="WDR2006chap2">United Nations Office on Drugs and Crime. 2006. [http://www.unodc.org/pdf/WDR_2006/wdr2006_chap2_biggest_market.pdf Cannabis: Why we should care]. World Drug Report, vol. 1. ISBN 92-1-148214-3 Retrieved on 10 Nov 2006</ref> with estimates of up to 20% or greater of the adult population in the United States having tried the drug, and 10–30% or greater using the herb in many European countries.
The possession, use, or sale of psychoactive cannabis products became [[Legal issues of cannabis|illegal]] in most parts of the world in the early 20th century. Since then, some countries have intensified the enforcement of cannabis [[Prohibition (drugs)|prohibition]] while others have reduced the priority of enforcement, almost to the point of legalization, as is the case in [[Drug policy of the Netherlands|the Netherlands]]. The production of cannabis for drug use remains illegal throughout most of the world through the 1961 [[Single Convention on Narcotic Drugs]], the 1971 [[Convention on Psychotropic Substances]], and the 1988 [[United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances]], while simple possession of small quantities is either legal, or treated as an addiction rather than a criminal offense in a few countries. The laws in the United States vary from state to state, some having decriminalized the possession of small amounts of marijuana although it is still a federal crime.
It has been reported that commercial hashish is often no more potent than high quality seedless marijuana.<ref name=baker1980a>Baker, P. B., K. R. Bagon, and T. A. Gough. 1980. [http://www.unodc.org/unodc/en/bulletin/bulletin_1980-01-01_4_page006.html Variation in the THC content in illicitly imported cannabis products]. ''Bulletin on Narcotics'' '''4''': 47-54. Retrieved 25 Feb 2007</ref> However, carefully produced and screened hashish is up to three times as potent as the highest quality herbal varieties.<ref name=clarke1998a>Clarke, R. C. 1998. Hashish! Red Eye Press. Los Angeles, California.</ref>
==Ancient history==
Botanists have determined that ''Cannabis'' is native to central Asia, possibly extending southward into the [[Himalayas]].<ref name=zuardi2006>Antonio Waldo Zuardi. 2006. [http://www.scielo.br/pdf/rbp/v28n2/29785.pdf History of cannabis as a medicine: a review]. ''Revista Brasileira de Psiquiatria'' '''28'''(2): 153-157. Retrieved on 25 Feb 2007</ref> Evidence of the inhalation of cannabis smoke can be found as far back as the [[Neolithic]] age, as indicated by charred ''Cannabis'' seeds found in a ritual [[brazier]] at an ancient burial site in present day [[Romania]].<ref name=rudgley1999>Richard Rudgley. 1999. ''The Lost Civilizations of the Stone Age''. Touchstone, New York. ISBN 0-684-85580-1</ref> The most famous users of cannabis were the ancient [[Hindu]]s of India and Nepal, and the [[Hashshashin]]s (hashish eaters) of present day Syria. The herb was called ''ganjika'' in [[Sanskrit]] (''ganja'' in modern Indian and Nepali languages).<ref name=leary1990>Timothy Leary. 1990. ''Flashbacks''. Tarcher/Putnam, New York. ISBN 0-87477-870-0 </ref><ref name="ganjikaEB">1911. [http://57.1911encyclopedia.org/H/HE/HEMP.htm| Hemp]. ''Encyclopædia Britannica'', 11th ed. Retrieved on 15 Jun 2006</ref> The ancient drug [[soma]], mentioned in the [[Veda]]s as a sacred intoxicating hallucinogen, was sometimes associated with cannabis.<ref name=rudgley1998>Richard Rudgley. 1998. [http://www.huxley.net/soma/index.html Soma]. The Encyclopedia of Psychoactive Substances. Little, Brown and Company, Great Britain. Retrieved on 25 Feb 2007</ref>
Cannabis was also known to the [[Assyrians]], who discovered its psychoactive properties through the [[Aryans]]. Using it in some religious ceremonies, they called it ''qunubu'' or ''the drug for sadness''. Cannabis was also introduced by the [[Aryans]] to the [[Scythia]]ns and [[Thracians]]/[[Dacia]]ns, whose [[shamanism|shamans]] (the ''kapnobatai'' - "those who walk on smoke/clouds") burned cannabis flowers to induce a state of trance. Members of the cult of [[Dionysus]], believed to have originated in [[Thrace]], are also thought to have inhaled cannabis smoke. In 2003, a leather basket filled with ''Cannabis'' leaf fragments and seeds was found next to a 2,500 to 2,800 year old [[mummy|mummified]] [[shaman]] in the northwestern [[Xinjiang]] Uygur Autonomous Region of [[China]].<ref name=peoplesdaily>2006. [http://english.peopledaily.com.cn/200612/23/eng20061223_335258.html Lab work to identify 2,800-year-old mummy of shaman]. ''People's Daily Online'' (English). Retrieved 25 Feb 2007</ref><ref name=jiang2006a>Hong-En Jiang, Xiao Li, You-Xing Zhao, David K. Ferguson, Francis Hueber, Subir Bera, Yu-Fei Wang, Liang-Cheng Zhao, Chang-Jiang Liu, and Cheng-Sen Li. 2006. [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8D-4K7WC0F-2&_user=10&_coverDate=12%2F06%2F2006&_rdoc=17&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%235084%232006%23998919996%23636769%23FLA%23display%23Volume)&_cdi=5084&_sort=d&_docanchor=&view=c&_ct=23&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=3e6ac8940b4b86b94935cd7a7d7bc19d A new insight into ''Cannabis sativa'' (Cannabaceae) utilization from 2500-year-old Yanghai tombs, Xinjiang, China]. ''Journal of Ethnopharmacology'' '''108'''(3): 414-422. Retrieved 25 Feb 2007</ref>
[[Cannabis]] has an ancient history of ritual use and is found in [[pharmacological cult]]s around the world. Hemp seeds discovered by archaeologists at [[Pazyryk]] suggest early ceremonial practices by the [[Scythians]] occurred during the 5th to 2nd century BCE, confirming previous historical reports by [[Herodotus]]. Some historians and etymologists have claimed that cannabis was used as a religious sacrament by ancient [[Jews]], early [[Christians]] and [[Muslims]] of the [[Sufi]] order. In [[India]] and [[Nepal]], it has been used by some of the wandering spiritual [[sadhu]]s for centuries, and in modern times the [[Rastafari movement]] has embraced it as a sacrament.<ref>Dread, The Rastafarians of Jamaica, by [[Joseph Owens]] ISBN 0-435-98650-3</ref> Elders of the modern religious movement known as the [[Ethiopian Zion Coptic Church]] consider cannabis to be the [[Eucharist]], claiming it as an oral tradition from [[Ethiopia]] dating back to the time of [[Christ]].<ref>http://www.druglibrary.org/schaffer/hemp/potbible.htm</ref> Like the Rastafari, some modern [[Gnostic]] Christian sects have asserted that cannabis is the Tree of Life. Other organized religions founded in the past century that treat cannabis as a sacrament are the [[THC Ministry]],<ref>http://www.thc-ministry.org/</ref> the [[Way of Infinite Harmony]], [[Cantheism]],<ref>http://www.ebeneezer.net/ritual/vegetable/offsite/Cantheist.html</ref> the [[Cannabis Assembly]]<ref>http://www.cannabisassembly.org/</ref> and the [[Church of cognizance]]. Many individuals also consider their use of cannabis to be spiritual regardless of organized religion. When the ancient Hindus or Vedic "Dharmas" used this drug they would often pray for increased wisdom.
== Medical use ==
{{main|Medical cannabis}}
Medical marijuana is a growing treatment for medical use. The American Marijuana Policy Project states that cannabis is an ideal therapeutic drug for cancer and AIDS patients, who often suffer from clinical depression, and from nausea and resulting weight loss due to chemotherapy and other aggressive treatments. [http://mpp.org] It is claimed that cannabis makes these other treatments more tolerable. The nausea suppression and mild analgesic effects of cannabis also provide a degree of relief for persons suffering from motion sickness, and it can also be used by hyperhidrosis sufferers for temporary relief of excessive sweating. A recent study by scientists in Italy has also shown that cannabidiol (CBD), a chemical found in marijuana, seriously inhibits the growth of cancer cells (including breast cancer) in animals. [http://www.norml.org/index.cfm?Group_ID=6917]. Both scientists and doctors agree that controlled doses of marijuana can help with Chemotherapy and Nausea Treatment, Appetite Stimulation, Glaucoma, Analgesia, and Movement Disorders.
===Medical Uses===
Chemotherapy and nausea have other treatments that THC, the main chemical in marijuana, like oral TITIC. This drug "[has] been effective in treating nausea associated with cancer chemotherapy if patients are pretreated and doses are repeated every 3 to 6 hours for approximately 24 hours." <ref>[http://mysite.verizon.net/aahpat/mum/mumcrs_12.htm]</ref> Medical Use of Marijuana: Policy and Regulatory Issues. This is why we need to continue looking for new drugs to treat these symptoms. “Additionally, the authors pointed out that ‘numerous safe and effective non-cannabinoids are available for the control of chemotherapy-associated nausea,’ and noted the importance of these alternatives ‘given the side effects found in studies of THC.’” <ref>[http://mysite.verizon.net/aahpat/mum/mumcrs_12.htm]</ref> Medical Use of Marijuana: Policy and Regulatory Issues. The Positive effects are really good but the negative effects are the reason this form of treatment is being held off. This is why scientists should continue their research and find a way to minimize the negative effects.
Cannabis has also been proven to treat anorexia according to a report published by the BBC in 2003. <ref>[http://news.bbc.co.uk/1/hi/health/3169901.stm Cannabis lifts Alzheimer appetite]</ref>. Medical marijuana will help with the lack of appetite due to AIDS or acquired immunodeficiency syndrome (the failure of the immune system to protect the body adequately from infection, due to the absence or insufficiency of some component process or substance.). Those with severe cancer related anorexia would benefit from using controlled doses of THC <ref>[http://mysite.verizon.net/aahpat/mum/mumcrs_12.htm]</ref> Medical Use of Marijuana: Policy and Regulatory Issues.
Glaucoma, a condition of increased pressure within the eyeball causing gradual loss of sight, can be treated with medical marijuana to decrease this intraocular pressure. “All sources agreed that cannabinoids [could] lower the intraocular pressure (lOP) associated with glaucoma in humans. Taylor also acknowledged that marijuana has therapeutic potential, but emphasized that… THC cannot penetrate into the coruea<ref>[http://mysite.verizon.net/aahpat/mum/mumcrs_12.htm]</ref> Medical Use of Marijuana: Policy and Regulatory Issues. This just says that there needs to be more studies to find a way to have the THC penetrate the coruea. Because it does have a strong out look for the future.
Medical marijuana is used for analgesia, or pain relief. “Marijuana is used for analgesia only in the context of a handful of illnesses [e.g., headache, dysentery, menstrual cramps, and depression] that are often cited by marijuana advocates as medical reasons to justify the drug being available as a prescription medication<ref>[http://mysite.verizon.net/aahpat/mum/mumcrs_12.htm]</ref> Medical Use of Marijuana: Policy and Regulatory Issues. It is also reported to be beneficial for treating certain neurological illnesses such as epilepsy, and bipolar disorder. Studies have found that cannabis can relieve tics in patients suffering from OCD and/or Tourette syndrome. Patients treated with marijuana reported a significant decrease in both motor and vocal tics, some of 50% or more. <ref name="ocd-ts-99">{{cite journal|author=K.R. Muller, U. Schneider, H. Kolbe, H.M. Emrich|title=''Treatment of Tourette's Syndrome With Delta-9-Tetrahydrocannabinol''|journal=American Journal of Psychiatry|year=1999|volume=156|issue=3|url=http://www.marijuana.org/AmJoPsychMarch99.html}}</ref><ref name="ocd-ts-02">{{cite journal|author=K.R. Muller, U. Schneider, A. Koblenz, M. Jöbges, H. Kolbe, T. Daldrup, H.M. Emrich|title=''Treatment of Tourette's Syndrome with Δ9-Tetrahydrocannabinol (THC): A Randomized Crossover Trial''|journal=Pharmacopsychiatry|year=2002|volume=35|issue=2|url=http://www.thieme-connect.com/ejournals/abstract/pharmaco/doi/10.1055/s-2002-25028}}</ref><ref name="ocd-ts-88">{{cite journal|author=R. Sandyk, G. Awerbuch|title=''Marijuana and Tourette's Syndrome''|journal=Journal of Clinical Psychopharmacology|year=1988|volume=8|issue=6|url=http://www.druglibrary.org/schaffer/hemp/medical/mjtouret.htm}}</ref> Some decrease in obsessive-compulsive behavior was also found. <ref name="ocd-ts-99">{{cite journal|author=K.R. Muller, U. Schneider, H. Kolbe, H.M. Emrich|title=''Treatment of Tourette's Syndrome With Delta-9-Tetrahydrocannabinol''|journal=American Journal of Psychiatry|year=1999|volume=156|issue=3|url=http://www.marijuana.org/AmJoPsychMarch99.html}}</ref> A recent study has also concluded that cannabinoids found in cannabis might have the ability to prevent Alzheimer's disease. <ref name="ADBlock">Ramíirez, B. G., C. Blázquez, T. Gómez del Pulgar, M. Guzmán, and M. L. de Ceballos. 2005. [http://www.jneurosci.org/cgi/content/abstract/25/8/1904 Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation]. ''Journal of Neuroscience'' '''25'''(8): 1904-1913. Retrieved on 27 Feb 2007</ref> THC has been shown to reduce arterial blockages. <ref name=steffens2005>Steffens, S., N. R. Veillard, C. Arnaud, G. Pelli, F. Burger, C. Staub, M. Karsak, A. Zimmer, J.-L. Frossard, and F. Mach. [http://www.nature.com/nature/journal/v434/n7034/abs/nature03389.html Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice]. ''Nature'' '''474'''(7034): 782-786. Retrieved 27 Feb 2007</ref> Marijuana has been used for centuries to relieve pain, but scientifically controlled studies confirming this use is almost nonexistent.
A recent epidemiological study funded by the National Institute of Health (NIH) concluded that, "the association of these [lung and upper aerodigestive tract] cancers with marijuana, even long-term or heavy use, is not strong and may be below practically detectable limits." <ref name=hashibe2006>Hashibe, M., H. Morgenstern, Y. Cui, D. P. Tashkin, Z.-F. Zhang, W. Cozen, T. M. Mack, and S. Greenland. 2006. [http://cebp.aacrjournals.org/cgi/content/abstract/15/10/1829 Marijuana use and the risk of lung and upper aerodigestive tract cancers: results of a population-based case-controlled study]. ''Cancer Epidemiology, Biomarkers & Prevention'' 15(10): 1829-1834. Retrieved on Feb 26 2007</ref><ref name=Bates2006>Bates, K. L. 16 Oct 2006. [http://www.umich.edu/~urecord/0607/Oct16_06/01.shtml Study fails to find link between marijuana use and cancer]. ''The University Record'' Online. University of Michigan. Retrieved on 26 Feb 2007</ref>
Another use for medical marijuana is movement disorders, although shown to work, does not have enough clinical support to regularly use for this purpose. “In the case of multiple sclerosis, IOM acknowledged that marijuana is frequently reported to reduce the muscle spasticity associated with the disease, but then it noted that these abundant anecdotal reports are not well-supported by clinical data. Evidence from animal studies [suggests that there is] a possible role for cannabinoids in the treatment of certain types of epileptic seizures” <ref>[http://mysite.verizon.net/aahpat/mum/mumcrs_12.htm]</ref> Medical Use of Marijuana: Policy and Regulatory Issues. The marijuana will numb the nervous system slightly so the body won’t go in to shock. A synthetic version of the major active compound in cannabis, THC, is available in capsule form as the prescription drug dronabinol (Marinol) in many countries. The prescription drug Sativex, an extract of cannabis administered as a sublingual spray has been approved in Canada for the treatment of multiple sclerosis. <ref name="SativexC">Koch, W. 23 Jun 2005. [http://www.usatoday.com/news/health/2005-06-23-pot-spray_x.htm Spray alternative to pot on the market in Canada]. ''USA Today'' (online). Retrieved on 27 Feb 2007</ref> Dr. William Notcutt states that the use of MS as the disease to study "had everything to do with politics." <ref name="Respectable Reefer">{{cite news|last=Greenberg|first=Gary|title=Respectable Reefer|publisher=Mother Jones|date=[[2005-11-01]]|url=http://www.motherjones.com/news/feature/2005/11/Respectable_Reefer-3.html|accessdate=2007-04-03}}</ref>
===Government Debate===
There are many claims regarding the use of cannabis in a medical context, both pro and con. [http://www.norml.org/index.cfm?Group_ID=3376][http://www.mpp.org/site/c.glKZLeMQIsG/b.1086505/k.AF5A/About.htm] On April 20, 2006 the United States Food and Drug Administration (FDA) issued an intra-agency advisory warning against medical cannabis, restating the Drug Enforcement Administration's position that marijuana has a very high potential for abuse, no currently accepted medical use, and a lack of accepted safety for use under medical supervision. [http://www.fda.gov/bbs/topics/NEWS/2006/NEW01362.html] The FDA also asserted that "there is currently sound evidence that smoked marijuana is harmful".
The official position of several medical organizations including the American Medical Association [http://www.ama-assn.org/apps/pf_new/pf_online?f_n=browse&doc=policyfiles/HnE/H-95.952.HTM], the National Multiple Sclerosis Society [http://www.nationalmssociety.org/Sourcebook-Marijuana.asp], the American Glaucoma Society, the American Academy of Ophthalmology [http://www.aao.org/education/library/cta/loader.cfm?url=/commonspot/security/getfile.cfm&PageID=1216] and the American Cancer Society [http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Smoking_Marijuana_May_Increase_Cancer_Risk.asp] is that they do not support smoking the herbal form of marijuana for medical use. [http://www.cedro-uva.org/lib/harrison.cannabis.09.html][http://www.drugwatch.org/T&L%20Medical%20Marijuana.htm] On June 6, 2005, the U.S. Supreme Court handed down a decision, which supported the Federal Government's position against "medical marijuana". [http://a257.g.akamaitech.net/7/257/2422/06jun20051130/www.supremecourtus.gov/opinions/04pdf/03-1454.pdf] Justices O'Connor, Rehnquist, and Thomas filed dissenting opinions.
Chief Justice William H. Rehnquist, who was fighting thyroid cancer, disagreed with the Supreme Court ruling that allows federal prosecutions of ill medical marijuana users. Rehnquist, 80, joined a dissent written by Justice Sandra Day O'Connor that said the states should be allowed to set their own policies for cannabis use. O'Connor, who has had breast cancer, said that states should decide on their own "the difficult and sensitive question of whether marijuana should be available to relieve severe pain and suffering.”
Currently the citizens of 12 states in the United States (upwards of 60 million people) have legalized cannabis for medical use, for treating certain illnesses. Additionally, six states have enacted decriminalization policies toward the drug. Because the federal government does not acknowledge any legitimate medical uses for cannabis, federal enforcement of prohibition continues in these states.
United States federal law currently registers cannabis as a Schedule I drug (along with heroin and LSD), and Marinol as a Schedule III drug, despite the fact that they have the same active ingredient. [http://www.usdoj.gov/dea/pubs/scheduling.html] The medical use of cannabis is politically controversial, but physicians sometimes recommend it informally despite the risk of federal prosecution in the United States.
==Relationship with other drugs==
Since its origin in the 1950s, the "[[gateway drug]]" hypothesis has been one of the central pillars of marijuana drug policy in the United States, but this model of cause and effect has not been proven.<ref name=Rand>2 Dec 2002. [http://www.rand.org/news/press.02/gateway.html RAND study casts doubt on claims that marijuana acts as "gateway" to the use of cocaine and heroin]. RAND Corporation. Retrieved on 27 Feb 2007</ref> Those who subscribe to this theory argue that cannabis use may lead one down the path of drug addiction, and should therefore be treated as a serious matter. Many researchers conclude that this model of behavior has little basis in fact, though other mental health professionals believe that studies support the "gateway drug" model.<ref name=journalwatch>Richard Saitz. 18 Feb 2003. [http://general-medicine.jwatch.org/cgi/content/full/2003/218/1 Is marijuana a gateway drug]? ''Journal Watch''. Retrieved on 27 Feb 2007</ref> Despite the conflicting results of such studies, many researchers agree that the illegal status of cannabis has a direct connection to the "gateway theory".<ref name=morral2002>Morral, A. R., D. F. McCaffrey, and S. M. Paddock. 2002. [http://pt.wkhealth.com/pt/re/addi/abstract00008514-200212000-00002.htm;jsessionid=FJcCcHlCKYl5fXMK7zv8F7TG4lS45njtnyJT4JVQJnnQflX8v29G!641301743!-949856144!8091!-1 Reassessing the marijuana gateway effect]. ''Addiction'' '''97'''(12): 1493-1504.</ref><ref>{{cite web|url=http://www.mpp.org/site/c.glKZLeMQIsG/b.1146183/k.AE54/FAQ.htm|title=Marijuana Policy Project- FAQ|accessdate=2006-12-24}}</ref> The reasoning goes that cannabis users are more likely than non-users to place themselves in situations where other illicit substances are being used. In order to acquire cannabis they are likely to become acquainted with people who use or sell other more stigmatized drugs such as [[cocaine]] or [[heroin]], which may lead to serious addictions. Using this philosophy, activities such as smoking tobacco and drinking alcohol may also be regarded as having a gateway effect on youth. [[Image:20drugs.gif|right|thumb|150px|A rational scale to assess the harm of drugs]]
Indeed, certain studies have shown that tobacco smoking is a better predictor of concurrent illicit drug use than smoking cannabis.<ref name=Torabi1993>Torabi, M. R., W. J. Bailey, and M. Majd-Jabbari. 1993. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8246462&dopt=Abstract Cigarette smoking as a predictor of alcohol and other drug use by children and adolescents: evidence of the "gateway drug effect"]. ''Journal of School Health'' '''63'''(7): 302-306. Retrieved on 25 Feb 2007</ref> With this argument in mind, certain activist groups such as [[NORML]] contend that legalizing cannabis would substantially reduce the use of other drugs by taking the distribution of marijuana out of the hands of criminals, and regulating it in a similar manner to [[alcohol]] or [[tobacco]].<ref>{{cite web|url=http://www.norml.org/index.cfm?Group_ID=3383|title=Marijuana Decriminalization & Its Impact on Use|accessdate=2007-01-29}}</ref> Government agencies such as the [[DEA]], however, claim that legalization would do far more harm than good, and would likely cause a rise in cannabis use.<ref>{{cite web|url=http://www.dea.gov/marijuana_position.html|title=The DEA Position on Marijuana|accessdate=2007-01-29}}</ref>
A study published in [[The Lancet]] 24 March 2007<ref>[http://www.thelancet.com/journals/lancet/article/PIIS0140673607604644/abstract Development of a rational scale to assess the harm of drugs of potential misuse] The Lancet 2007; 369:1047-1053</ref> finds that cannabis is both less harmful and less addictive than either alcohol or tobacco. Twenty drugs were assigned a risk from 0 to 3. Cannabis was ranked 17th out of 20 for harmfulness, while alcohol and tobacco were ranked 11th and 14th respectively. Cannabis was ranked 11th for dependence while alcohol was 6th and tobacco 3rd, behind heroin and cocaine.
== New breeding and cultivation techniques ==
{{main|Cannabis (drug) cultivation}}
It is often claimed by growers and breeders of herbal cannabis that advances in breeding and cultivation techniques have increased the potency of cannabis since the late 1960s and early '70s. However, potent seedless marijuana such as "Thai sticks" were already available at that time. In fact, the [[Cannabis (drug) cultivation#Sinsemilla|''sinsemilla'' technique]] of producing high potency ganja (marijuana) has been practiced in India for centuries. Sinsemilla (Spanish for ''without seed''), is the dried, seedless inflorescences of female cannabis plants. Because [[tetrahydrocannabinol|THC]] production drops off once pollination occurs, the male plants (which produce little THC themselves) are eliminated before they shed pollen to prevent pollination. Advanced cultivation techniques such as [[Cannabis (drug) cultivation#Hydroponic cultivation|hydroponics]], [[Cannabis (drug) cultivation#Feminized seeds|cloning]], [[Cannabis (drug) cultivation#Lighting|high-intensity artificial lighting]], and [[Cannabis (drug) cultivation#Sea of green|the sea of green method]] are frequently employed as a response (in part) to prohibition enforcement efforts that make outdoor cultivation more risky. These intensive horticultural techniques have led to fewer seeds being present in cannabis and a general increase in potency over the past 20 years.
Many opponents of cannabis use, both in and out of government, have exaggerated the increases in potency and ramifications thereof. In the United States, government advertisements encourage parents to disregard their own experiences with cannabis when speaking to their children, on the premise that the <!-- don't change this, it is intentionally -->"pot"<!-- like in the ads to which I refer --><!-- could you cite those ads? --> of today is significantly stronger, and thus more dangerous, than that which they used in the past.<ref name="More potent">{{cite press release|publisher=[[United States Department of Health and Human Services]]|date=[[2004-09-09]]|url=http://www.dhhs.gov/news/press/2004pres/20040909b.html|title=Nation's Youth Turning Away from Marijuana, as Perceptions of Risk Rise; Most Adults with Substance Abuse Problems Are Employed|accessdate=2006-05-30}}</ref> In proposed revisions to [[Cannabis reclassification in the United Kingdom|cannabis rescheduling]] in the U.K., the government is considering scheduling the more potent cannabis material as a separate, more restricted substance. Many cannabis proponents are vehemently opposed, reasoning that if one can smoke less cannabis to achieve the same effect, then it is safer in the long run than smoking a less potent product.
There are two recognized types of herbal cannabis, "sativa" and "indica". So-called "sativa" strains are reputed to induce a noticeably more "cerebral" high, while "indica" strains induce more of a body high. These two drug types are often hybridized or crossed with early-maturing (but low in THC) "ruderalis" strains to increase the range in desirable characteristics.
== Preparations for human consumption ==
[[Image:HOcannabis.jpg|thumb|200px|Herbal cannabis "buds"]]
Cannabis is prepared for human consumption in several forms:
* ''[[Marijuana]]'' or ''[[ganja]]'': the leaves and flowering tops of female plants
* ''[[Hashish]]'' or ''[[charas]]'': a concentrated resin composed of glandular trichomes and vegetative debris that has been physically extracted, usually by rubbing, sifting, or with ice
[[Image:HOresin.jpg|thumb|150px|Hash with 5p piece for size comparison]]
* ''[[Kief]]'' or ''[[kif]]'': 1) the chopped flowering tops of female cannabis plants, often mixed with tobacco; 2) Moroccan hashish produced in the Rif mountains;<ref name=kif>Anouk Zijlma. [http://goafrica.about.com/od/morocco/a/moroccokif.htm Smoking hashish in Morocco]. Retrieved on 27 Feb 2007</ref> 3) sifted cannabis trichomes consisting of only the glandular "heads" (often incorrectly referred to as "crystals" or "pollen") 4) The crystal (trichomes) left at the bottom of a grinder after grinding marijuana; then smoked.
* ''[[Bhang]]'': a beverage prepared by grinding cannabis leaves in milk and boiling with spices and other ingredients
* ''[[Hash oil]]'': an oily mixture resulting from chemical [[solvent extraction|extraction]] or [[distillation]] of the THC-rich parts of the plant, THC usually ~ 10-20% and up to 70%{{Fact|date=April 2007}}
* ''[[Budder]]'': hash oil whipped to incorporate air, making it more like butter
These forms are not exclusive, and mixtures of two or more different forms of cannabis are frequently consumed. Between the many different strains of cannabis and the various ways that it is prepared, there are innumerable variations similar to the wide variety of mixed alcoholic beverages that are consumed.
==
{{main|Cannabis smoking}}
[[Image:HOpipes.jpg|thumb|right|300px|Variety of cannabis-smoking paraphernalia.]]
There are a wide variety of methods and apparatus for smoking cannabis. The most popular include the [[Joint (cannabis)|joint]], the [[Blunt (cigar)|blunt]], the [[bong]], the [[smoking pipe (non-tobacco)|pipe]] (more commonly called a "bowl" or "piece"), the [[shotgun (cannabis)|shotgun]], the [[chillum]], the deffy and the [[dugout (smoking)|one-hitter]] or "bat." Cannabis is sometimes smoked within a small enclosed area (such as a car) to trap the smoke, so that it is inhaled with every breath. This is often referred to as "[[hotboxing]]," "fishbowling," "baking," "jeaning," "clam-baking," "green-housing", "the aquarium" (in Belgium), creating a "potmosphere," or (in Australia), a "compression session." One can also smoke marijuana in a steam-filled environment (bathroom, sauna), with the added humidity intended to produce a greater high, called a "Jamaican shower".
[[Image:Smokingthebowl3.PNG|thumb|left|Smoking cannabis out of a [[Smoking pipe (non-tobacco)|pipe]]]]
The classic [[bong]] is a tube with a small bowl (at the end of a thinner tube) inserted through the side, near the base. The bong is partially filled with water for the smoke to bubble through. The herb is placed in the bowl and ignited. After filling the tube with smoke, it is "cleared" by removing one's finger from a hole in the side called a "choke" (or "carb"), or by pulling the bowl up and out which is called a slide (or a "pull-carb"). Homemade bongs are sometimes made with plastic soda bottles. Smoking marijuana through a bong concentrates the smoke, and it is often followed by fits of coughing and laughter. Variants include the [[gravity bong]] (also known as a bucket bong), which consists of a cone atop a perforated or cut water bottle. This method of cannabis smoking is one of the most efficient, as the presence of a chamber and "carburetor" hole reduce smoke waste. With a bong, one can consume greater amounts of cannabis in one "hit" than with an ordinary pipe. Another similar smoking device is known as a "waterfall bong". This is usually made by poking a hole in the bottom of a plastic water bottle and either sticking a bowl through a hole in the cap, or resting the bowl over the top. The hole in the bottom is covered with a finger, and the bottle filled with water. The bowl is placed on top of the bottle and lit by holding a flame over it and moving the finger covering the hole. As the water drains out, a vacuum is created, pulling smoke into the bottle. When the water has all drained out, the bowl is removed and the smoke is sucked out of the bottle, often very quickly. The effects of this type of bong are usually felt almost immediately, and often very intensely.
Pipes are usually made of [[Glassblowing|blown glass]], wood, or non-reactive metals. Metal pipes are often made of interchangeable pieces. Glass pipes often have a "carburetor" hole, colloquially referred to as a ''carb,'' ''rush,'' ''choke,'' ''shotgun,'' or ''shooter'' (British use) that is covered for suction and then released to draw a mixture of smoke and air into the lungs. Some users prefer vertically held pipes (chillums), or improvised pipes (e.g., "tinnies" or "foilies") made from aluminium foil, small plumbing fittings, soda cans, crisp fruits or vegetables, or the cardboard tubes from bathroom-tissue or aluminium foil rolls.
A "one-hitter" is a device that enables a small amount of cannabis to be burned and inhaled in a single breath. The cannabis is loaded into one end of a small screenless tube (usually brass), and the entire amount is smoked at once. This is repeated for each hit. This method is useful for carefully [[Titration|titrating]] the desired dose. One-hitters are often disguised to fool people into believing that one is smoking an authentic cigarette. This deception is more effective (but less healthy) if the cannabis is mixed with a little tobacco.
The "apple Bowl" is yet another way of smoking cannabis. An apple is poked from the top and side creating a tube.Marijuana is then placed in the top opening and lit.The user then inhales the smoke from the other opening.
Effects of smoking marijuana: Some physical effects are dry mouth, dry eyes, increased heart rate, bloodshot eyes, and puffy eyelids. The psychological effects are relaxation, euphoria, altered time perception, and alteration of visual, auditory, and olfactory senses. There are also some negative effects of marijuana use but there seem to be no real chronic effects. Short-term effects of marijuana use are; short-term memory loss, anxiety, irritation, . Once the person quits smoking or ingesting THC, the side effects soon disappear.
=== Vaporization ===
A ''[[vaporizer]]'' heats herbal cannabis to 365–410 °F (185–210 °C), which turns the active ingredients into [[gas]] without burning the plant material (the boiling point of THC is 200°C at 0.02 mm Hg pressure, and somewhat higher at standard atmospheric pressure).<ref name=volcano>[http://www.storz-bickel.com/pics/down/Lufttemperaturtabelle%20-%20Air%20temperatur%20table.pdf Air Temperature Table]. Volcano<sup>tm</sup> Operating Manual. Storz & Bickel, Tuttlingen, Germany.</ref><ref name=merck1989>1989. ''The Merck Index'', 11th ed., Merck & Co., Rahway, New Jersey</ref> Toxic chemicals are released at much lower levels than by smoking, although this may vary depending on the design of the vaporizer and the temperature at which it is set. A study by [[MAPS]]/[[NORML]], using a [[Volcano vaporizer|Volcano<sup>tm</sup>]] vaporizer reported 95% THC and no toxins delivered in the vapor. However, an older study using less sophisticated vaporizers found more toxins. The effects from a vaporizer are noticeably different to that of smoking cannabis. Users have reported a more euphoric hallucinogen type high which is due to the more pure amount of THC being taken in.
<ref name="norml1">{{cite journal
| quotes =
| last = Gieringer
| first = Dale H.
| authorlink =
| coauthors = Joseph St. Laurent, Scott Goodrich
| date =
| year = 2004
| month =
| title = Cannabis Vaporizer Combines Efficient Delivery of THC with Effective Suppression of Pyrolytic Compounds
| journal = Journal of Cannabis Therapeutics
| volume = 4
| issue = 1
| pages = 7-27
| doi = 10.1300/J175v04n01_02
| id =
| url = http://www.maps.org/mmj/Gieringer-vaporizer.pdf
| language =
| format = pdf
| accessdate = 2006-04-21
}}</ref><ref name="norml2">{{cite web|url=http://www.maps.org/news-letters/v06n3/06359mj1.html|title=Marijuana Water Pipe and Vaporizer Study|last=Gieringer|first=Dale|accessdate=2006-04-21}}</ref>
=== Eating cannabis ===
As an alternative to smoking, cannabis may be consumed orally. Although [[hashish]] is sometimes eaten raw or mixed with water, THC and other cannabinoids are more efficiently absorbed into the bloodstream when dissolved in [[ethanol]], or combined with butter or other [[lipid]]s. The effects of cannabis administered this way take longer to begin, but last longer. They are sometimes perceived as more physical than mental, although there are many claims to the contrary. An oral dose of cannabis is often considered to give a more intense experience than the equivalent dose of smoked cannabis. Some people report unpleasant experiences after ingesting cannabis, because they experience a more intense effect than they are comfortable with.
Smoking cannabis results in a significant loss of THC and other cannabinoids in the exhaled smoke, by decomposition on burning, and in smoke that is not inhaled. In contrast, all of the active constituents enter the body when cannabis is ingested. It has been shown that the primary active component of cannabis, Δ9-THC, is converted to the more psychoactive [[11-hydroxy-THC]] by the liver.<ref name="11-hydroxy">{{cite journal| author=Paulo Borini; Romeu Cardoso Guimarães; Sabrina Bicalho Borini| year=2004| month=May| title= ''Possible hepatotoxicity of chronic marijuana usage''| journal=Sao Paulo Medical Journal| volume=122| issue=3| doi=10.1590/S1516-31802004000300007| url=http://www.scielo.br/scielo.php?pid=S1516-31802004000300007&script=sci_arttext&tlng=en| accessdate=2006-05-02}}</ref> [[Titration]] to the desired effect by ingestion is much more difficult than through inhalation.
A common method of preparation involves blending cannabis material with butter to create "[[cannabutter]]", which is used in preparing foods such as [[Cannabis brownie|brownies]], [[fudge]], [[hash cookie|cookies]], "[[ganja goo ball]]s," and "[[space cake]]s". Before blending with melted butter, the plant material is often finely ground, almost to a powder. A more refined form of cannabutter is prepared by heating cannabis material with butter and water for an extended period of time, without bringing to a complete boil. The vegetative material is then removed by filtering through a strainer or cheese cloth, and the water and butter are allowed to separate, leaving clarified cannabutter to be used in various recipes. However, some recipes do not contain butter and fall into a slightly different category; these delicacies include the "[[Leary biscuit]]," which require less work to prepare than more "conventional" recipes. Cannabis infusions (known as [[Bhang]]) containing [[milk]], spices, and other ingredients are commonly consumed in India and elsewhere, especially on festive occasions.
In 2006, hollowed-out gumballs filled with cannabis material and labeled as "Greenades" were distributed by high school students in the United States.<ref name="Greenades">{{cite news|url=http://www.prweb.com/releases/2006/7/prweb414446.htm|title=Greenades, Marijuana Gumballs, Identified by Maryland Police, Used by High School Students|publisher=[[PR Web]]|date=[[2006-07-22]]|accessdate=2006-09-15}}</ref>
As with other drugs taken orally, it is sometimes customary to [[Fasting|fast]] before eating cannabis to increase the effect, possibly because an empty stomach will enable the THC to enter the bloodstream more quickly. However, some people eat ordinary food before consuming the drug, because eating it on an empty stomach can cause nausea. The time to onset of effects is usually about an hour and may continue for a considerable length of time, whereas the effects of smoking herbal cannabis are almost immediate.
Cannabis material can be [[Leaching|leached]] in high-proof spirits (often [[neutral grain spirit|grain alcohol]]) to create "[[Green Dragon (drink)|Green Dragon]]." This process is often employed to make use of low-potency stems and leaves.
Cannabis can also be consumed as a [[tea]]. Although THC is [[lipophilic]] and only slightly [[water]] [[solubility|soluble]] (with a solubility of 2.8 grams per litre<ref name="water solubility">{{cite web|url=http://lib1.bmcc.cuny.edu/studres/projectsakinde.html|title=The Medical Applications of Cannabinoids|author=Akinde Omotayo|publisher=[[Borough of Manhattan Community College]]|accessdate=2006-09-15}}</ref>), enough THC can be dissolved to make a mildly psychoactive tea. However, water-based infusions are generally considered to be an inefficient use of the herb.
Cannabis "seeds" (technically called achenes), which are not psychoactive, are high in [[protein]] and essential [[fatty acid]]s, and are readily consumed by many species of birds. They are also consumed by humans, and are a key ingredient in certain traditional recipes in Europe, and elsewhere. In many countries, including the United States and Canada, possession of viable cannabis seeds is illegal.<ref name="DEA">{{cite web|url=http://www.usdoj.gov/dea/agency/csa.htm|title=Controlled Substances Act|work=21 USCS § 801|publisher=United States Drug Enforcement Agency|accessdate=November 4|accessyear=2005}}</ref>
== Immediate effects of consumption ==
The nature and intensity of the immediate (as opposed to long-term) effects of cannabis consumption vary depending on such factors as dose, potency, cannabinoid (and possibly terpenoid) composition, method of consumption, length of time since last usage, the user's mental and physical state, and their surroundings. These last two factors are sometimes referred to as ''[[set and setting]]''. Smoking the same cannabis material in different frames of mind (set) or in different locations (setting) can alter the effects of the drug, or one's perception of the effects. What the user does while under the influence of cannabis can also alter the effects. If the user is inactive they may feel relaxed and sleepy, whereas if the user engages in physical or mental activity they may feel energized. The effects of cannabis consumption may be loosely classified as cognitive and physical. Anecdotal evidence suggests that ''sativa'' drug varieties tend to produce greater cognitive or perceptual effects than ''indica'' varieties, which tend to produce more physical effects.
===The high===
Cannabis intoxication is the state of being intoxicated to a degree that mental and physical facilities are noticeably altered due to the consumption of cannabis. Each user experiences a different high, and the nature of it may vary upon factors such as potency, dose, chemical composition, method of consumption and [[set and setting]].
Highs vary from
* A feeling of [[euphoria]]
* Intense relaxation
* Most experience pleasure, but one out of five users experience a great deal of anxiety.<ref name="high">http://www.hightimes.com/ht/news/content.php?bid=1202&aid=10</ref>
* Decrease in nausea (used medicinally for this)
* Laughter, giggle fits
* sensory enhancement (colours, taste, sensation)
* increased appreciation of music
Other common short-term effects include
* Forgetfulness
* Laziness
* Distorted perception
* Trouble with concentration
* Paranoia
* Increased heart rate
* Dry mouth and throat,<ref>http://www.drugfree.org/Portal/drug_guide/Marijuana</ref>
* Increased appetite.<ref name="high"/>
* The consumption of chocolate results in a dopamine-serotonin release in the brain that is magnified greatly during the high. It causes an interesting shimmer in visual-auditory perception and a sudden euphoria.{{Fact|date=May 2007}}
====="Munchies"=====
The "Munchies" is a term that is often used to describe the increased appetite that comes from using Cannabis. Research performed by the [[National Institutes of Health]] claimed that marijuana increases food enjoyment and the number of times a person eats each day. Recently, scientists have claimed to be able to explain what causes the increase in appetite, concluding that "[[endocannabinoid]]s in the [[hypothalamus]] activate [[cannabinoid]] receptors that are responsible for maintaining food intake."<ref>http://health.howstuffworks.com/marijuana4.htm</ref>
=== Toxicity ===
According to the [[Merck Index]],<ref name=merck1996>1996. ''The Merck Index'', 12th ed., Merck & Co., Rahway, New Jersey</ref> the [[LD50]] (dosage lethal to 50% of rats tested) of Δ<sup>9</sup>-THC by inhalation is 42 mg/kg of body weight. That is the equivalent of a 165 lb (75 kg) man inhaling the [[Tetrahydrocannabinol|THC]] found in 21 one-gram cigarettes of extremely high-potency (15% THC) marijuana all in one sitting, assuming no THC is lost through smoke loss or absorption by the lungs. For oral consumption, the LD50 for male rats is 1270 mg/kg, and 730 mg/kg for females—equivalent to the THC in about a pound of 15% THC marijuana.<ref name="Erowid">{{cite web|url=http://www.erowid.org/plants/cannabis/cannabis_chemistry.shtml|title=Cannabis Chemistry|accessdate=2006-03-20|author=Erowid}}</ref> The ratio of cannabis material required to saturate cannabinoid receptors to the amount required for a fatal overdose is 1:40,000.<ref>[http://www.medic8.com/medicines/Marijuana.html]</ref> There have been no reported deaths or permanent injuries sustained as a result of a marijuana overdose. It is practically impossible to overdose on marijuana, as the user would certainly either fall asleep or otherwise become incapacitated from the effects of the drug before being able to consume enough THC to be mortally toxic. While it has never been reported, it is theoretically feasible for concentrated THC (hash or oil) to cause an overdose. We also learn by comparing LD50s that the toxicity of the cannabis is significantly lower than that of the alcohol or other frequently consumed products.
==== Adulterated Cannabis ====
[[Contaminants]] are rife in street cannabis; low-quality hashish such as [[soap bar]] has a reputation for being full of contaminants (some [[psychoactive]], some not) which serve to increase the bulk of the street product {{Fact|date=April 2007}}. Recently, there have been reports of herbal cannabis being adulterated with minute [[silica]] crystals in the [[UK]] and [[Ireland]]. These crystals resemble [[THC]] in appearance, yet are much heavier, and so serve again to increase the weight, and hence value, of the cannabis on the street. {{Fact|date=May 2007}}
== Health issues and the effects of cannabis ==
{{main|Health issues and the effects of cannabis}}<!-- #######HIATEOC####### -->
Although there are many conflicting studies involving health issues and the effects of cannabis, certain [[body|physical]] and [[mind|mental]] [[health]] effects conclusions have been reached. Today, there is still a substantial amount of [[propaganda]] and [[misinformation]] from both cannabis advocates and opponents due to the [[legal issues of cannabis]], including legal and political constraints on cannabis research.
Cannabis is currently recognized as a psychologically addictive drug. There is no cannabis withdrawal disorder in the [[DSM-IV]], but studies have demonstrated that cannabis use can induce withdrawal symptoms similar to other drugs with recognized physical dependence. Cannabis withdrawal symptoms are similar in magnitude and time-course to the well-established tobacco withdrawal syndrome.<ref>{{cite journal |author=Budney A |title=Are specific dependence criteria necessary for different substances: how can research on cannabis inform this issue? |journal=Addiction |volume=101 Suppl 1 |issue= |pages=125-33 |year=2006 |pmid=16930169}}</ref>
The most obvious confounding factor in cannabis research is the prevalent usage of other recreational drugs, including [[alcohol]] and [[tobacco]].<ref name=zhang1999>Zhang, Z.-F., Morgenstern, H., Spitz, M. R., Tashkin, D. P., Yu, G.-P., Marshall, J. R., Hsu, T. C., and Schantz, S. P. 1999. [http://cebp.aacrjournals.org/cgi/content/full/8/12/1071 Marijuana use and increased risk of squamous cell carcinoma of the head and neck]. Cancer Epidemiology, Biomarkers & Prevention 8(12):1071-1078. Retrieved 4 Mar 2007</ref> Such complications demonstrate the need for studies on cannabis that have stronger controls, and investigations into the symptoms of cannabis use that may also be caused by [[tobacco]]. Most cannabis research within the USA is funded by government agencies who in turn publish position papers citing research studies that spotlight the negative consequences of cannabis use.<ref name=NIDAresearchreport>National Institute on Drug Abuse. 2005. [http://www.nida.nih.gov/PDF/RRMarijuana.pdf ''Marijuana Abuse. Research Report, Series 3'']. NIH Pub. No. 05-3859. Retrieved on 5 Mar 2007</ref><ref name=NIDAresearchreportrefs>National Institute on Drug Abuse. 2005. ''Marijuana Abuse. Research Report, Series 3''. [http://www.nida.nih.gov/ResearchReports/Marijuana/Marijuana6.html#references References]. pp. 1-6. Retrieved on 5 Mar 2007</ref> In light of this, some people question whether these agencies make an honest effort to present an accurate, unbiased summary of the evidence, or whether they "cherry-pick" their data, and others caution that the raw data, and not the final conclusions, are what should be examined.<ref name=Transform> [http://www.tdpf.org.uk/MediaNews_FactResearchGuide_public_opinion.htm Public opinion on drugs and drug policy]. Transform Drug Policy Foundation: Fact Research Guide. "Data is notoriously easy to cherry pick or spin to support a particular agenda or position. Often the raw data will conceal all sorts of interesting facts that the headlines have missed." Transform Drug Policy Foundation, Easton Business Centre, Felix Rd., Bristol, UK. Retrieved on 24 March 2007.</ref>
Unlike tobacco, cannabis has not been shown to cause [[emphysema]], lung cancer, or chronic obstructive pulmonary disease.<ref name="Tobacco">{{cite news|url=http://www.mapinc.org/drugnews/v05/n1106/a09.html?275821|title=Marijuana Smoking Does Not Cause Lung Cancer|org=Anderson Valley Advertiser|author=Fred Gardner|date=[[2006-07-06]]}}</ref><ref name=tashkin1997>Tashkin, D. P., Simmons, M. S., Sherrill, D. L., and Coulson, A. H. 1997. [http://ajrccm.atsjournals.org/cgi/content/abstract/155/1/141 Heavy habitual marijuana smoking does not cause an accelerated decline in FEV1 with age]. ''American Journal of Respiratory and Critical Care Medicine'' '''155'''(1): 141-148. Retrieved on 5 Mar 2007</ref><ref name="UCLA study">{{cite news|url=http://www.washingtonpost.com/wp-dyn/content/article/2006/05/25/AR2006052501729_pf.html|title=Study finds no marijuana-lung cancer link|publisher=[[Washington Post]]|date=[[2006-05-26]]|accessdate=2006-07-13}}</ref><!-- #######need better citation from HIATEOC####### --> Other studies have suggested that cannabis use by expectant mothers does not appear to cause birth defects or developmental delays in their newborn children.<ref name="BirthDefects">{{cite journal|author=J.S. Hayes, R. Lampart, M.C. Dreher, L. Morgan|title=Five-year follow-up of rural Jamaican children whose mothers used marijuana during pregnancy|journal=West Indian Medical Journal|year=1991|volume=40|issue=3|pages=120-3}}</ref><ref name="BirthDefects2">Dreher, M. C., Nugent, K., Hudgins, R. 1994. [http://pediatrics.aappublications.org/cgi/content/abstract/93/2/254 Prenatal marijuana exposure and neonatal outcomes in Jamaica: an ethnographic study]. ''Pediatrics'' '''93'''(2): 254-260. Retrieved on 5 Mar 2007</ref> According to a United Kingdom government report, using cannabis is less dangerous than tobacco, prescription drugs, and alcohol in social harms, physical harm and addiction.<ref name="UK government report">{{cite news|url=http://news.bbc.co.uk/1/shared/bsp/hi/pdfs/31_07_06_drugsreport.pdf|title=UK government report|publisher=House of Commons Science and Technology Committee|date=[[2006-07-18]]|accessdate=2006-08-29}}]</ref> There have been zero (0) recorded medical deaths from the use of cannabis.
Cannabis is known to act on the [[hippocampus]] (an area of the brain associated with [[memory]] and [[learning]]), and impair short term memory and attention for the duration of its effects and in some cases for the next day. In the long term, some studies point to enhancement of particular types of memory.<ref name=iversen2003>Iversen, L. 2003. Cannabis and the brain. ''Brain'' '''126'''(6): 1252-1270. Retrieved on 5 Mar 2007</ref>
Cannabis was found to be [[neuroprotection|neuroprotective]] against [[excitotoxicity]] and is therefore beneficial for the prevention of progressive [[degeneration|degenerative]] [[diseases]] like [[Alzheimer's disease]].<ref name="Nepr">[http://www.jneurosci.org/cgi/content/abstract/21/17/6475] Neuroprotection by 9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity, M. van der Stelt, W. B. Veldhuis, P. R. Bär, G. A. Veldink1, J. F. G. Vliegenthart, and K. Nicolay, The Journal of Neuroscience, September 1, 2001 </ref> A 1998 report commissioned in France by Health Secretary of State [[Bernard Kouchner]] and directed by Dr. Pierre-Bernard Roques determined that, "former results suggesting anatomic changes in the brain of chronic cannabis users, measured by [[tomography]], were not confirmed by the accurate modern [[neuroimaging|neuro-imaging techniques]]," (like [[Magnetic resonance imaging|MRI]]). "Moreover, morphological impairment of the [[hippocampus]] [which plays a part in memory and navigation] of rat after administration of very high doses of THC (Langfield ''et al.'', 1988) was not shown (Slikker ''et al.'', 1992)" (translated). He concluded that cannabis does not have any neurotoxicity as defined in the report, unlike alcohol and cocaine.<ref name=roques1998> [[INSERM]]-[[Centre national de la recherche scientifique|CNRS]]. Released June 1998. [http://www.chanvre-info.ch/info/en/Hemp-is-less-toxic-than-alcohol-or.html Excerpts from the Roques report]. Hemp Info. Retrieved 5 Mar 2007</ref><ref name=lesverts>[http://www.lesverts.fr/article.php3?id_article=2092 Rapport Roques sur la dangerosité des drogues]. (in French). Retrieved on 5 Mar 2007</ref><ref name=esculapepro>[http://www.esculape.com/politique/alcooldrogue.html L'alcool aussi dangereux que l'héroïne]. (in French) Retrieved on 5 Mar 2007</ref>
Research between the use of cannabis and mental illness has also brought significant results. Cannabis use is generally higher among sufferers of [[schizophrenia]], but the [[causality]] between the two has not been established.<ref name=henquet2005>Henquet, C., Krabbendam, L., Spauwen, J., Kaplan, C., Lieb, R., Wittchen, H.-U., and van Os, J. 2005. [http://www.bmj.com/cgi/content/full/330/7481/11?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&author1=Henquet&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=330&fdate=1/1/2002&tdate=3/31/2006&resourcetype=HWCIT Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people]. ''BMJ'' '''330'''(7481): 11. Retrieved on 4 Mar 2007</ref><ref name =patton2002>Patton, G. C., Coffey, C., Carlin, J. B., Degenhardt, L., Lynskey, M., and Hall, W. 2002. [http://www.bmj.com/cgi/content/full/325/7374/1195?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&author1=Patton&author2=Coffey&title=Cannabis+Cohort&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&fdate=1/1/2000&tdate=3/31/2006&resourcetype=HWCIT Cannabis use and mental health in young people: cohort study]. ''BMJ'' '''325'''(7374): 1195-1198. Retrieved 45 Mar 2007</ref> Another study concluded that sustained early-adolescent cannabis use among genetically predisposed individuals has been associated with a variety of mental illness outcomes, ranging from [[psychotic]] episodes to clinical [[schizophrenia]].<ref name=arseneault2002>Arseneault, L., Cannon, M., Poulton R., Murray R., Caspi, A., and Moffitt, T. E. 2002. [http://www.bmj.com/cgi/content/full/325/7374/1212?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&author1=Arseneault&author2=Cannon&title=Cannabis&andorexacttitle=or&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=325&firstpage=1212&fdate=1/1/2000&tdate=3/31/2004&resourcetype=HWCIT Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study]. ''BMJ'' '''325'''(7374): 1212-213. Retrieved on 5 Mar 2007</ref><ref name=caspi2005>Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H., Taylor, A., Arseneault, L., Williams, B., Braithwaite, A., Poulton, R., and Craig, I. W. 2005. [http://www.ukcia.org/research/COMTgene.pdf Moderation of the effect of adolescent-onset Cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction]. ''Society of Biological Psychiatry'' '''57''': 1117-1127. Retrieved on 5 Mar 2007</ref>
== Legality ==
[[Image:World-cannabis-laws.png|right|thumb|201px|World laws on [[cannabis]] possession (small amount). Data is from multiple sources detailed on the [[Image talk:World-cannabis-laws.png|full source list]]. This map is a work in progress. Please give corrections and additions [[User talk:CL8|here]].]]
[[Image:European-cannabis-laws.png|right|thumb|201px|European laws on cannabis possession (small amount). Data is from multiple sources detailed on the [[Image talk:World-cannabis-laws.png#Europe|full source list]]. This map is a work in progress. Please give corrections and additions [[User talk:CL8|here]].]]
{{main|Legal issues of cannabis}}
Since the 20th century, most countries have enacted laws against the cultivation, use, possession, or transfer of cannabis for recreational use. Naturally, these laws impact adversely on the cannabis plant's cultivation for non-recreational purposes, but there are many regions where, under certain circumstances, handling of cannabis is legal or licensed, and others where laws against its use, possession, or sale are not enforced. Many jurisdictions have also ''decriminalized'' possession of small quantities of cannabis, so that it is punished by [[confiscation]] or a [[fine]], rather than [[imprisonment]]. By effectively removing the user from the criminal justice system, decriminalization focuses more on those who [[Trafficking|traffic]] and sell the drug on the [[black market]]. However, this does not solve the problem of how a user will obtain the "legal amount" of cannabis, since buying or growing cannabis is still illegal. Increasingly, many jurisdictions also permit cannabis use for medicinal purposes. Some countries allow the sale through drug companies.{{Fact|date=February 2007}} However, simple possession can carry long jail sentences in some countries, particularly in [[East Asia]], where the sale of cannabis may lead to a sentence of life in prison or even execution.{{Fact|date=March 2007}}
[[Image:Map-of-US-state-cannabis-laws.png|thumb|200px|United States cannabis laws. Blue represents states with [[medical cannabis]] laws; red represents states with [[decriminalization]] laws; purple represents states with both.]]
[[Image:420 9.jpg|right|thumb|200px|A large scale anti-prohibition demonstration in [[Vancouver]], [[Canada]], on [[April 20]], [[2005]].]]
[[Image:Killerdrug.jpg|right|thumb|200px|U.S. Federal Bureau of Narcotics [[public service announcement|PSA]] used in the late 1930s and 1940s.]]
=== Recent history ===
Under the name ''cannabis'', 19th century medical practitioners sold the drug, (usually as a [[tincture]]) popularizing the word amongst English-speakers. It was rumoured to have been used to treat [[Victoria of the United Kingdom|Queen Victoria]]'s [[menstrual]] pains as her personal physician, Sir John Russell Reynolds, was a staunch supporter of the benefits of cannabis.<ref name="Reynolds">{{cite web|url=http://jnnp.bmjjournals.com/cgi/content/full/75/8/1148|title=Positive and negative cerebral symptoms: the roles of Russell Reynolds and Hughlings Jackson|accessdate=2006-03-25}}</ref> Cannabis was also openly available from shops in the US. By the end of the 19th century, its medicinal use began to fall as other drugs like [[aspirin]] took over its use as a pain reliever.
In 1894, the ''Report of the Indian Hemp Drugs Commission'' commissioned by the UK Secretary of State and the government of India, was instrumental in the decision not to criminalize the drug in those countries. The ''Report'', which at over 500 pages remains one of the most complete collections of information on cannabis in existence, shows the stark contrast in the way that the American and British governments went about deciding whether to criminalize cannabis.<ref>Kaplan, J. (1969) "Introduction" of the ''Report of the Indian Hemp Drugs Commission'' ed. by The Honorable W. Mackworth Young, ''et al.'' (Simla: Government Central Printing Office, 1894) LCCN 74-84211, pp. v-vi.</ref>
In 1937 the F.D. Roosevelt administration crafted the first national US law making cannabis possession illegal in the US via an unpayable tax on the drug. Hollywood supported that effort with the release of "misinformation documentaries" such as the iconical "[[Reefer Madness]]" (1937).
The name ''marijuana'' ([[Mexican Spanish]] ''marihuana'', ''mariguana'') is associated almost exclusively with the plant's psychoactive use. The term is now well known in English largely due to the efforts of American drug prohibitionists during the 1920s and 1930s, which deliberately used a [[Mexican]] name for cannabis in order to turn the populace against the idea that it should be legal, playing upon attitudes towards race. (''See [[1937 Marihuana Tax Act]]''). Those who demonized the drug by calling it marihuana omitted the fact that the "deadly marihuana" was identical to cannabis indica, which had at the time a reputation for pharmaceutical safety.<ref>{{cite journal
| quotes = Remarkably, neither of the preceding articles explain that the deadly marihuana is precisely identical to cannabis indica! This fact might well have surprised readers, given cannabis' reputation for pharmaceutical safety.
| last = Gieringer
| first = Dale H.
| authorlink =
| coauthors =
| date = 2006-06-17
| year = 1999
| month =
| title = The Origins of Cannabis Prohibition in California
| journal = Contemporary Drug Problems
| volume = 26
| issue = 2
| pages =
| doi =
| id =
| url = http://canorml.org/background/caloriginsmjproh.pdf
| language =
| format =
| accessdate = 2007-01-05
}} p.13</ref>
Although cannabis has been used for its psychoactive effects since ancient times, it first became well known in the United States during the [[jazz]] music scene of the late 1920s and 1930s. [[Louis Armstrong]] became a prominent and life-long devotee. It was popular in the blues scene as well, and eventually became a prominent part of 1960s counterculture.
=== Decriminalization and legalization ===
{{main|Legal issues of cannabis}}
In recent decades, a movement to [[Decriminalization|decriminalize]] cannabis has arisen in several countries. 12 US states have passed by majority vote of the citizenry, laws allowing some degree of medical use, while a further 6 states have taken steps to decriminalize it to some degree. This movement seeks to make simple possession of cannabis punishable by only confiscation or a fine, rather than prison. In the past several years, the movement has started to have some successes. These include [[Denver, Colorado]] legalizing possession of up to an ounce of cannabis,<ref name="Denver">{{cite news|url=http://www.usatoday.com/news/nation/2005-11-03-pot_x.htm|title=Denver votes to legalize marijuana possession|author=Patrick O'Driscoll|publisher=USA Today|date=[[2005-11-03]]|accessdate=2006-03-11}}</ref> a broad coalition of [[political party|political parties]] in [[Amsterdam]], [[Netherlands]] unveiling a pilot program to allow farmers to grow it legally,<ref name="NLfarming">{{cite web|url=http://www.twincities.com/mld/twincities/news/breaking_news/13313479.htm|title=Dutch Politicians Seek Marijuana Rules|accessdate=2006-02-25}}</ref> and [[Massachusetts]] voting in favor of a bill to decriminalize the possession of up to an ounce of cannabis.<ref name="Mass">{{cite web|url=http://www.heraldnews.com/site/news.cfm?newsid=16135095|title=Marijuana fight nears|accessdate=2006-02-17}}</ref> These laws passed by states and cities to decriminalize marijuana do not result in marijuana being legal, however. The Federal Government has the power to regulate marijuana because of the Commerce Clause of the United States Constitution. Additionally, under the Supremacy Clause, any state law in conflict with federal law is not valid. These issues were squarely addressed by the United States Supreme Court in ''[[Raich v. Ashcroft]]'', 352 F. 3d 1222.
In Alaska, cannabis was decided legal for in-home, personal use under the Ravin vs. State ruling in 1975. This ruling allowed up to four ounces of cannabis for these purposes. A 1991 voter ballot initiative recriminalized marijuana possession, but when that law was eventually challenged in 2004, the Alaska court's upheld the Ravin ruling, saying the popular vote could not trump the state constitution. In response to former Governor Frank Murkowski's successive attempt to re-criminalize cannabis, the [[ACLU]] filed a lawsuit against the state. On [[July 17]], 2006, Superior Court Judge Patricia Collins awarded the Case [[Summary judgment]] to the ACLU. In her ruling, she said "No specific argument has been advanced in this case that possession of more than 1 ounce of cannabis, even within the privacy of the home, is constitutionally protected conduct under Ravin or that any plaintiff or ACLU of Alaska member actually possesses more than 1 ounce of cannabis in their homes." This does not mean that the legal possession threshold has been reduced to one ounce, as this was a mere case summary review filed by the ACLU, not a full case. Reinforcing ''Ravin'', Collins wrote "A lower court cannot reverse the State Supreme Court's 1975 decision in Ravin v. State" and "Unless and until the Supreme Court directs otherwise, ''Ravin'' is the law in this state and this court is duty bound to follow that law". The law regarding possession of cannabis has not changed in Alaska, and the Supreme Court has declined to review the case, therefore the law still stands at 4 ounces.{{Fact|date=February 2007}}
In 2002, Nevada voters defeated a ballot question which would legalize up to 3 ounces for adults 21 and older by 39% to 61%. In 2006, a similar Nevada ballot initiative, which would have legalized and regulated the cultivation, distribution, and possession of up to 1 ounce of marijuana by adults 21 and older, was defeated by 44% to 56%.
In 2001 in the United Kingdom, it was announced that cannabis would become a Class C drug, rather than a Class B, this change took effect on January 29, 2004. Since then there has recently been some controversy amongst UK politicians about the message this sends out, with some calling for its reclassification to Class B.<ref name="Blunkett">{{cite web|url=http://www.idmu.co.uk/homeoffpr.htm|title=Home Office- Class B to Class C|accessdate=2006-03-27}}</ref>
The [[Government of Mexico]] voted to legalize the possession of cannabis under 5 grams on [[April 28]], [[2006]].<ref name="mexicolegal"> {{cite news|first=Noel|last=Randewich|Author=Noel Randewich|url=http://news.yahoo.com/s/nm/20060428/ts_nm/mexico_drugs_dc|title=Mexico to decriminalize pot, cocaine and heroin|publisher=[[Reuters]]|date=[[2006-04-28]]|accessdate=2006-04-28}}</ref> However, as of [[May 3]], [[2006]], Mexican President
[[Vicente Fox]] has said that he will not sign this proposed law until Congress removes the parts that would decriminalize the possession of small quantities of drugs<ref name="mexicoillegal">{{cite news|url=http://news.yahoo.com/s/nm/20060504/ts_nm/mexico_drugs_dc_3|title=Mexico's Fox won't sign drug law|publisher=[[Reuters]]|date=[[2006-05-03]]|accessdate=2006-05-04}}</ref> and vetoed the bill on [[May 4]], [[2006]],<ref name="veto">{{cite news|url=http://www.signonsandiego.com/news/mexico/20060504-9999-1n4fox.html|title=Mexican legal drug proposal rejected|publisher=Sign On San Diego|date=[[2006-05-04]]|accessdate=2006-05-13}}</ref> sparking broad controversy over the bill.<ref name="deniespressure">{{cite news|url=http://www.dominicantoday.com/app/article.aspx?id=13096|title=Mexico denies drug law veto result of US pressure|publisher=Dominican Today|date=[[2006-05-04]]|accessdate=2006-05-13}}</ref><ref name="consulateprotest">{{cite news|url=http://www.scoop.co.nz/stories/HL0605/S00095.htm|title=Protest at Mexican Consulate in New York, Friday|publisher=Scoop|date=[[2006-05-05]]|accessdate=2006-05-13}}</ref><ref name="smokein">{{cite news|url=http://www.foxnews.com/story/0,2933,194552,00.html|title=Drug Bill Veto Sparks Mexico City Marijuana Smoke-In|publisher=[[Fox News]]|date=[[2006-06-05]]|accessdate=2006-05-13}}</ref> In the early summer of 2006 Fox and the Mexican congress came to an agreement and legalized possession of small amounts (and also measured amounts of other drugs). On July 17, 2006, [[Italy|Italian]] Social Solidarity Minister [[Paolo Ferrero]], speaking of the urgent need for depenalising the consumption of light drugs, said that "a joint is less harmful than a litre of [[wine]]."<ref name=Paolo>{{cite news|url=http://www.agi.it/english/news.pl?doc=200607171332-1085-RT1-CRO-0-NF82&page=0&id=agionline-eng.italyonline|accessdat2--6-07-26|title=DRUG: FERRERO DECRIMINALIZE CONSUMPTION OF LIGHT DRUGS|date=[[2006-07-17]]|publisher=Agenzia Giornalistica Italia}}</ref> In the [[Australian Capital Territory]], possession of up to 25 grams, or five plants, is not a criminal offence but carries a $100 fine.{{Fact|date=February 2007}} In [[South Australia]] however, possession of cannabis is an offense, with fines ranging from $150 to $300 for possession and cultivation of small amounts.[http://www.dassa.sa.gov.au/site/page.cfm?u=129] There is much confusion on the subject, with many people believing that possession of a certain amount is legal. In South Australia however, this is a myth.
=== Legality in Hong Kong===
Cannabis is regulated under section 9 of Hong Kong's Chapter 134 ''Dangerous Drugs Ordinance''.
Cultivation and dealing with cannabis plant is illegal and a fine of $100,000 and to imprisonment for 15 years can be laid by the court. Anyone who supplies the substance without prescription can be fined $10,000(HKD). The penalty for trafficking or manufacturing the substance is a $5,000,000 (HKD) fine and life imprisonment. Possession of the substance for consumption without license from the Department of Health is illegal with a $1,000,000 fine and/or 7 years of jail time.
=== Legality in the United States ===
{{main|Legal history of marijuana in the United States}}
{{seealso|Cannabis rescheduling in the United States}}
{{seealso|Decriminalization of marijuana in the United States}}
Under federal law, it is illegal to possess, use, buy, sell, or cultivate marijuana anywhere in the United States. The [[Comprehensive Drug Abuse Prevention and Control Act of 1970|Controlled Substances Act of 1970]] classifies marijuana as a Schedule I drug, meaning it has a high potential for abuse and no accepted medical use. Under the [[Supremacy Clause]] of the [[Constitution]], Federal law in the United States preempts conflicting state and local laws. Nevertheless, some states and local governments have established laws attempting to decriminalize cannabis, which has reduced the number of "simple possession" offenders sent to jail, since federal enforcement agents rarely target individuals directly for such relatively minor offenses. Other state and local governments ask law enforcement agencies to limit enforcement of drug laws with respect to cannabis. In the 2006 election, amendment 44 of Colorado making it legal to possess less than 1 ounce of marijuana, failed and the election was 40-60, yet it is still a misdemeanor to possess up to one half pound, and is punished mainly by fines unless sale is established.
The National Center for Natural Products Research in [[Oxford, Mississippi]] is the only facility in the United States that is federally licensed by the [[National Institute on Drug Abuse]] to cultivate cannabis for scientific research. The Center is part of the School of Pharmacy at the University of Mississippi.
==See also==
<div style="-moz-column-count:2; column-count:2;">
<!-- Links below may duplicate links already in the main body of the text. Please remove any duplicates. -->
*[[420 (cannabis culture)]]
*[[BC Bud]]
*[[Bhang]]
*[[Cannabis coffee shops]]
*[[Cannabis political parties]]
*[[Cheech & Chong]]
*[[Drug policy of the Netherlands]]
*[[Drug test]]
*[[Eagle Bill]]
*[[Emerald Triangle]]
*[[Fitz Hugh Ludlow]] ("The Hasheesh Eater")
*[[Global Marijuana March]]
*[[Hash oil]]
*[[Head shop]]
*[[Health issues and the effects of cannabis]]
*[[Illegal drug trade]]
*[[Jack Herer]]
*[[Legal issues of cannabis]]
*[[Legality of cannabis by country]]
*[[List of cannabis strains]]
*[[Marc Emery]]
*[[National Organization for the Reform of Marijuana Laws (United States)|National Organization for the Reform of Marijuana Laws]]
*[[Psychoactive drug]]
*[[Seed bank]]
*[[Shake (cannabis)|Shake]]
*[[Soap bar]]
*[[Thai stick]]
*[[Stoner (cannabis)|Stoner]]
*[[Stoner metal|Stoner rock]]
*[[Victor robinson|Victor Robinson]]
*[[War on Drugs]]
*[[wikt:Wiktionary Appendix:Cannabis Slang|Wiktionary appendix of cannabis slang]]
</div>
==References==
{{reflist|2}}
=== Bibliography ===
* {{cite news|url=http://select.nytimes.com/gst/abstract.html?res=F10E1FFB35580C748EDDA90994DA404482|author=Howard Markel|title=For Addicts, Relief May Be an Office Visit Away|publisher=New York Times|date=[[2002-10-27]]}}
* {{cite journal|url=http://www.ukcia.org/research/CannabisUseInAdolescenceAndRiskForAdultPsychosis.pdf|author=Louise Arsenault, Mary Cannon, Richie Poulton, Robin Murray, Avshalom Caspi, and Terrie E. Moffitt|title=Cannabis use in adolescence and risk for adult psychosis: longtudinal prospective study|year=2002|journal=British Medical Journal|volume=325|pages=1212 – 1213}}
* {{cite journal|url=http://www.ukcia.org/research/COMTgene.pdf|Author=|title=Moderation of the effect of adult-onset cannabis use on adult psychosis by a functional polymorphism in the Catchol-O-Methyltransferase gene: Longitudinal evidence of a gene X environment interaction|author=Avshalom Caspi, Terrie E. Moffitt, Mary Cannon, Joseph McClay, Robin Murray, HonaLee Harrington, Alan Taylor, Louise Arsenault, Ben Williams, Antony Braithwaite, Richie Poulton, and Ian W. Craig|year=2005|journal=Biol Psychiatry|volume=25|pages=1117 – 1127}}
* {{cite news|url=http://www.timesonline.co.uk/article/0,,3561-1565337,00.html|title=One in four at risk of cannabis psychosis|first=Mark|last=Henderson|publisher=The Times|date=[[2005-04-12]]}}
* Bruce Mirken and Neel Makwana (Aston Birmingham): {{cite news|url=http://www.alternet.org/drugreporter/21436/|date=[[2005-03-07]]|title=Psychosis, Hype And Baloney|publisher=AlterNet}}
* {{cite journal|url=http://ehp.niehs.nih.gov/docs/2000/108-10/correspondence.html#thc|title=Antitumor Effects of THC|journal=Environmental Health Perspectives|volume=108(10)|year=October 2000|pages=Correspondence|author=James Huff and Po Chan | id=PMID 11097557}}
* ''Cannabis: A History'' (2005). Martin Booth - ISBN 0-312-32220-8
* Long term impact of Cannabis use of 16 year olds {{cite news|url=http://www.highbeam.com/doc/1G1-113852471.html?refid=hbw_sw|date=[[2004-01-01]]|title=Long-term impact of the Gatehouse Project on Cannabis use of 16-year-olds in Australia.(Research Papers)|publisher=journal of school health}}
==External links==
*[http://parentingteens.about.com/cs/marijuana/l/bldicmarijuana.htm Various slang terms for cannabis]
*[http://www.rollitup.org/ Marijuana Growing]
*[http://cannabis.com/faqs/ Comprehensive Cannabis Faqs and Marijuana information]
{{Cannabis resources}}
{{Cannabinoids}}
<!-- currently unused, need to merge back into the article
== History ==
[[Image:Seed_close_up.jpg|right|thumb|A close up picture of a cannabis seed]]
Cannabis was known as a medicinal and psychoactive compound in some early societies, and has been used continuously in many parts of the world. Other societies have developed a social [[stigma]] surrounding the drug. <!-- repression in various Islamic centuries (11th, 13th, and others), early modern (ex-Ottoman) Greece, Egypt under Mehemet Ali (19th century), need sections -->
[[Category:Psychedelics, dissociatives and deliriants]]
[[Category:Cannabis]]
[[Category:Medicinal plants]]
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