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'''Gertrude Belle Elion''' ([[January 23]], [[1918]] – [[February 21]], [[1999]]) was an [[United States|American]] [[biochemistry|biochemist]] and [[pharmacology|pharmacologist]], and a 1988 recipient of the [[Nobel Prize in Physiology or Medicine]]. Born in [[New York City]] to [[Jew]]ish immigrant parents, she graduated from [[Hunter College]] in 1937 and [[New York University]] (M.Sc.) in 1941. Unable to obtain a graduate research position due to her [[Female|sex]], she worked as a lab assistant and a high school teacher, before becoming an assistant to [[George H. Hitchings]] at the [[Burroughs-Wellcome]] pharmaceutical company (now [[GlaxoSmithKline]]). She never obtained a formal [[Doctor of Philosophy|Ph.D.]], but she was later awarded an honorary Ph.D from George Washington University.
Working alone as well as with Hitchings, Elion developed a multitude of new [[medication|drugs]], using innovative research methods that would later lead to the development of the [[AIDS]] drug [[AZT]]. Rather than relying on trial-and-error, Elion and Hitchings used the differences in biochemistry between normal human cells and [[pathogen]]s (disease-causing agents) to design drugs that could kill or inhibit the reproduction of particular pathogens without harming the host cells.
Elion's inventions include:
* [[Mercaptopurine|6-mercaptopurine]] (Purinethol), the first treatment for [[leukemia]].[http://pubs.acs.org/cen/coverstory/83/8325/83256-mercaptopurine.html]
* [[Azathioprine]] (Imuran), the first [[immunosuppressive drug|immuno-suppressive agent]], used for [[organ transplant]]s.
* [[Allopurinol]] (Zyloprim), for [[gout]].
* [[Pyrimethamine]] (Daraprim), for [[malaria]].
* [[Trimethoprim]] (Septra), for [[meningitis]], [[septicemia]], and [[bacterial infection]]s of the [[urinary tract|urinary]] and [[respiratory tract]]s.
* [[Aciclovir|Acyclovir]] (Zovirax), for viral [[herpes]].
In 1988 Elion received the Nobel Prize in Medicine, together with Hitchings and [[James W. Black|Sir James Black]]. Other awards include the [[National Medal of Science]] (1991) and the [[Lemelson-MIT Prize|Lemelson-MIT Lifetime Achievement Award]] (1997). In 1991 she became the first woman to be inducted into the [[National Inventors Hall of Fame]].
Gertrude Elion died in North Carolina in 1999, aged 81. She had moved to the [[Research Triangle]] in 1970, and for a time served as a research professor at [[Duke University]]. She was unmarried and had 2 children.
==Quotes==
* "I had no specific bent toward science until my grandfather died of stomach cancer. I decided nobody should suffer that much."
* "The idea was to do research, find new avenues to conquer, new mountains to climb!"
==
* [[Garvan-Olin Medal]] (1968)
* [[Nobel Prize]] in Medicine (1988)
* [[National Medal of Science]] (1991)
* [[Lemelson-MIT Prize]] (1997)
* [[National Inventors Hall of Fame]] (1991) (first woman to be inducted)
==External links==
*[http://www.nobel.se/medicine/laureates/1988/elion-autobio.html Autobiography at the Nobel e-Museum]
*[http://www.nap.edu/html/biomems/gelion.html Biographical Memoirs by Mary Ellen Avery]
*[http://www.jwa.org/exhibits/wov/elion/ Women of Valor exhibit on Gertrude Elion] at the [http://www.jwa.org Jewish Women's Archive]
{{Nobel Prize in Physiology or Medicine Laureates 1976-2000}}
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