Signal transducing adaptor molecule: Difference between revisions

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{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

'''Signal transducing adapter molecule 1''' is a [[protein]] that in humans is encoded by the ''STAM'' [[gene]].<ref name="pmid8780729">{{cite journal | vauthors = Takeshita T, Arita T, Asao H, Tanaka N, Higuchi M, Kuroda H, Kaneko K, Munakata H, Endo Y, Fujita T, Sugamura K | title = Cloning of a novel signal-transducing adaptor molecule containing an SH3 ___domain and ITAM | journal = Biochemical and Biophysical Research Communications | volume = 225 | issue = 3 | pages = 1035–9 | date = August 1996 | pmid = 8780729 | doi = 10.1006/bbrc.1996.1290 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STAM signal transducing adaptor molecule (SH3 ___domain and ITAM motif) 1| url = https://www.ncbi.nlm.nih.gov/sites/entrezgene?Db=gene&Cmd=ShowDetailView&TermToSearch=8027}}</ref>

== Function ==

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* {{cite journal | vauthors = Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, Takeshita T, Endo Y, Fujita T, Sugamura K | title = Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth | journal = The Journal of Biological Chemistry | volume = 272 | issue = 52 | pages = 32785–91 | date = December 1997 | pmid = 9407053 | doi = 10.1074/jbc.272.52.32785 | doi-access = free }}

* {{cite journal | vauthors = Tanaka N, Kaneko K, Asao H, Kasai H, Endo Y, Fujita T, Takeshita T, Sugamura K | title = Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines | journal = The Journal of Biological Chemistry | volume = 274 | issue = 27 | pages = 19129–35 | date = July 1999 | pmid = 10383417 | doi = 10.1074/jbc.274.27.19129 | doi-access = free }}

* {{cite journal | vauthors = Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K | title = STAM2, a new member of the STAM family, binding to the Janus kinases | journal = FEBS Letters | volume = 477 | issue = 1–2 | pages = 55–61 | date = July 2000 | pmid = 10899310 | doi = 10.1016/S0014-5793(00)01760-9 | s2cid = 31811757 | doi-access = free }}

* {{cite journal | vauthors = Kato M, Miyazawa K, Kitamura N | title = A deubiquitinating enzyme UBPY interacts with the Src homology 3 ___domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP | journal = The Journal of Biological Chemistry | volume = 275 | issue = 48 | pages = 37481–7 | date = December 2000 | pmid = 10982817 | doi = 10.1074/jbc.M007251200 | doi-access = free }}

* {{cite journal | vauthors = Pandey A, Fernandez MM, Steen H, Blagoev B, Nielsen MM, Roche S, Mann M, Lodish HF | title = Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways | journal = The Journal of Biological Chemistry | volume = 275 | issue = 49 | pages = 38633–9 | date = December 2000 | pmid = 10993906 | doi = 10.1074/jbc.M007849200 | doi-access = free }}

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* {{cite journal | vauthors = Blackstone C, Roberts RG, Seeburg DP, Sheng M | title = Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1 | journal = Biochemical and Biophysical Research Communications | volume = 305 | issue = 2 | pages = 345–52 | date = May 2003 | pmid = 12745081 | doi = 10.1016/S0006-291X(03)00767-8 }}

* {{cite journal | vauthors = Mizuno E, Kawahata K, Kato M, Kitamura N, Komada M | title = STAM proteins bind ubiquitinated proteins on the early endosome via the VHS ___domain and ubiquitin-interacting motif | journal = Molecular Biology of the Cell | volume = 14 | issue = 9 | pages = 3675–89 | date = September 2003 | pmid = 12972556 | pmc = 196559 | doi = 10.1091/mbc.E02-12-0823 }}

* {{cite journal | vauthors = Mizuno E, Kawahata K, Okamoto A, Kitamura N, Komada M | title = Association with Hrs is required for the early endosomal localization, stability, and function of STAM | journal = Journal of Biochemistry | volume = 135 | issue = 3 | pages = 385–96 | date = March 2004 | pmid = 15113837 | doi = 10.1093/jb/mvh046 | doi-access = free }}

* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = July 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}

* {{cite journal | vauthors = Kobayashi H, Tanaka N, Asao H, Miura S, Kyuuma M, Semura K, Ishii N, Sugamura K | title = Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2 | journal = The Journal of Biological Chemistry | volume = 280 | issue = 11 | pages = 10468–77 | date = March 2005 | pmid = 15640163 | doi = 10.1074/jbc.M409969200 | doi-access = free }}