Endothelin converting enzyme 1: Difference between revisions

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{{Short description|Mammalian protein found in Homo sapiens}}

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'''Endothelin converting enzyme 1''', also known as '''ECE1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ECE1 endothelin converting enzyme 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1889| accessdate = }}</ref>

{{Infobox_gene}}

'''<span lang="fr" dir="ltr">Endothelin</span> converting enzyme 1''', also known as '''ECE1''', is an [[enzyme]] which in humans is encoded by the ''ECE1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ECE1 endothelin converting enzyme 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1889}}</ref><ref name="pmid7805846">{{cite journal | vauthors = Schmidt M, Kröger B, Jacob E, Seulberger H, Subkowski T, Otter R, Meyer T, Schmalzing G, Hillen H | title = Molecular characterization of human and bovine endothelin converting enzyme (ECE-1) | journal = FEBS Lett. | volume = 356 | issue = 2–3 | pages = 238–43 |date=December 1994 | pmid = 7805846 | doi = 10.1016/0014-5793(94)01277-6| doi-access = free }}</ref><ref name="pmid7864876">{{cite journal | vauthors = Shimada K, Matsushita Y, Wakabayashi K, Takahashi M, Matsubara A, Iijima Y, Tanzawa K | title = Cloning and functional expression of human endothelin-converting enzyme cDNA | journal = Biochem. Biophys. Res. Commun. | volume = 207 | issue = 2 | pages = 807–12 |date=February 1995 | pmid = 7864876 | doi = 10.1006/bbrc.1995.1258 | doi-access = free }}</ref>

== Function ==

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{{PBB_Summary

Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 ([[endothelin 1|EDN1]]), -2 ([[endothelin 2|EDN2]]), and -3 ([[endothelin 3|EDN3]]) to biologically active peptides.<ref name="entrez" />

| section_title =

| summary_text = Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1; MIM 131240), -2 (EDN2; MIM 131241), and -3 (EDN3; MIM 131242) to biologically active peptides.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: ECE1 endothelin converting enzyme 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1889| accessdate = }}</ref>

}}

==References==

{{reflist}}

==Further reading==

{{refbegin | 2}}

*{{cite journal | vauthors=Yorimitsu K, Moroi K, Inagaki N |title=Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2 |journal=Biochem. Biophys. Res. Commun. |volume=208 |issue= 2 |pages= 721–7 |year= 1995 |pmid= 7695628 |doi=10.1006/bbrc.1995.1397 |display-authors=etal}}

{{PBB_Further_reading

*{{cite journal | vauthors=Schmidt M, Kröger B, Jacob E |title=Molecular characterization of human and bovine endothelin converting enzyme (ECE-1) |journal=FEBS Lett. |volume=356 |issue= 2–3 |pages= 238–43 |year= 1995 |pmid= 7805846 |doi=10.1016/0014-5793(94)01277-6 |display-authors=etal|doi-access=free }}

| citations =

*{{cite journal | authorvauthors=SmollichShimada MK, GötteMatsushita MY, YipWakabayashi GW, ''et al.''K |title=OnCloning and thefunctional roleexpression of human endothelin-converting enzyme 1 (ECE-1) and neprilysin in human breast cancer.cDNA |journal=BreastBiochem. CancerBiophys. Res. TreatCommun. |volume=106207 |issue= 32 |pages= 361–9807–12 |year= 20071995 |pmid= 172950447864876 |doi= 10.10071006/s10549bbrc.1995.1258 |display-007authors=etal|doi-9516-9access=free }}

*{{cite journal | authorvauthors=YorimitsuValdenaire KO, MoroiRohrbacher KE, InagakiMattei N, ''et al.''MG |title=CloningOrganization andof sequencingthe ofgene aencoding the human endothelin -converting enzyme in renal adenocarcinoma (ACHNECE-1) cells producing endothelin-2. |journal=BiochemJ. BiophysBiol. Res. CommunChem. |volume=208270 |issue= 250 |pages= 721–729794–8 |year= 19951996 |pmid= 76956288530372 |doi=10.1074/jbc.270.50.29794 |doi-access=free }}

*{{cite journal | authorvauthors=SchmidtMatsuoka MR, KrögerSawamura BT, JacobYamada E, ''et al.''K |title=Molecular characterization of human and bovineHuman endothelin converting enzyme gene (ECE-1ECE1) mapped to chromosomal region 1p36.1 |journal=FEBSCytogenet. Cell LettGenet. |volume=35672 |issue= 2-34 |pages= 238–43322–4 |year= 19951996 |pmid= 78058468641140 |doi=10.1159/000134214 |display-authors=etal}}

*{{cite journal | authorvauthors=ShimadaOrzechowski KHD, MatsushitaRichter YCM, WakabayashiFunke-Kaiser K, ''et al.''H |title=CloningEvidence andof functionalalternative promoters directing isoform-specific expression of human endothelin-converting enzyme-1 cDNA.mRNA in cultured endothelial cells |journal=BiochemJ. BiophysMol. Res. CommunMed. |volume=20775 |issue= 27 |pages= 807–12512–21 |year= 19951997 |pmid= 78648769253714 |doi= 10.10061007/bbrc.1995.1258s001090050136 |s2cid=34633812 |display-authors=etal}}

*{{cite journal | authorvauthors=ValdenaireSchweizer OA, RohrbacherValdenaire EO, MatteiNelböck MGP |title=Organization of the gene encoding the humanHuman endothelin-converting enzyme (ECE-1).: three isoforms with distinct subcellular localizations |journal=JBiochem. Biol. ChemJ. |volume=270328 |issue= 50 Pt 3|pages= 29794–8871–7 |year= 19961998 |pmid= 85303729396733 |doi= 10.1042/bj3280871| pmc=1218999 |display-authors=etal}}

*{{cite journal | authorvauthors=MatsuokaKido RT, Sawamura T, YamadaMasaki K, ''et al.''T |title=HumanThe endothelinprocessing convertingpathway enzymeof geneendothelin-1 (ECE1) mapped to chromosomal region 1p36.1.production |journal=CytogenetJ. CellCardiovasc. GenetPharmacol. |volume=7231 |issuepages= 4S13–5 |pagesyear= 322–41998 |yearissue=Suppl 19961 |pmid= 86411409595387 |doi=10.1097/00005344-199800001-00006 |doi-access=free }}

*{{cite journal | authorvauthors=OrzechowskiHofstra HDRM, RichterValdenaire CMO, Funke-KaiserArch H, ''et al.''E |title=EvidenceA loss-of alternative promoters directing isoform-specificfunction expressionmutation ofin humanthe endothelin-converting enzyme 1 (ECE-1) mRNAassociated inwith culturedHirschsprung endothelialdisease, cells.cardiac defects, and autonomic dysfunction |journal=Am. J. MolHum. MedGenet. |volume=7564 |issue= 71 |pages= 512–21304–8 |year= 19971999 |pmid= 92537149915973 |doi=10.1086/302184 | pmc=1377732 |display-authors=etal}}

*{{cite journal | authorvauthors=SchweizerLee AS, ValdenaireLin OM, NelböckMele P, ''et al.''A |title=HumanProteolytic endothelin-convertingprocessing enzymeof (ECEbig endothelin-1):3 threeby isoformsthe withkell distinctblood subcellulargroup localizations.protein |journal=Biochem. J.Blood |volume=328 ( Pt 3)94 |issue= 4 |pages= 871–71440–50 |year= 19981999 |pmid= 939673310438732 |doi= 10.1182/blood.V94.4.1440|display-authors=etal}}

*{{cite journal | authorvauthors=KidoValdenaire TO, SawamuraLepailleur-Enouf TD, MasakiEgidy TG |title=TheA processingfourth pathwayisoform of endothelin-converting enzyme (ECE-1) production.is generated from an additional promoter molecular cloning and characterization |journal=JEur. CardiovascJ. PharmacolBiochem. |volume=31 Suppl 1264 |issue= 2 |pages= S13–5341–9 |year= 19981999 |pmid= 959538710491078 |doi=10.1046/j.1432-1327.1999.00602.x |display-authors=etal|doi-access=free }}

*{{cite journal | authorvauthors=HofstraFahnoe RMDC, ValdenaireJohnson OGD, ArchHerman ESB, ''etAhn al.''K |title=ADisulfide loss-ofbonds in big ET-function1 mutationare inessential for the endothelin-convertingspecific enzymecleavage 1at the Trp(ECE21)-1Val(22) associatedbond withby Hirschsprungsoluble disease,endothelin cardiacconverting defects,enzyme-1 andfrom autonomicbaculovirus/insect dysfunction.cells |journal=AmArch. JBiochem. Hum. GenetBiophys. |volume=64373 |issue= 12 |pages= 304–8385–93 |year= 19992000 |pmid= 991597310620363 |doi= 10.1006/abbi.1999.1586 }}

*{{cite journal | authorvauthors=LeeLópez-Ongil S, LinSenchak MV, MeleSaura A, ''et al.''M |title=ProteolyticSuperoxide processingregulation of big endothelin-3converting byenzyme the|journal=J. kell blood groupBiol. proteinChem. |journal=Blood |volume=94275 |issue= 434 |pages= 1440–5026423–7 |year= 19992000 |pmid= 1043873210833511 |doi= 10.1074/jbc.M000767200 |display-authors=etal|doi-access=free }}

*{{cite journal | authorvauthors=ValdenaireHachiya OA, Lepailleur-EnoufKobayashi DT, EgidyTakema GY, ''etImokawa al.''G |title=ABiochemical fourth isoformcharacterization of endothelin-converting enzyme-1alpha in cultured (ECEskin-1)derived iscells generatedand fromits anpostulated additionalrole promoterin molecularthe cloningstimulation andof characterization.melanogenesis in human epidermis |journal=EurJ. JBiol. BiochemChem. |volume=264277 |issue= 27 |pages= 341–95395–403 |year= 19992002 |pmid= 1049107811723113 |doi= 10.1074/jbc.M105874200 |doi-access= free }}

*{{cite journal | authorvauthors=FahnoeInguimbert DCN, JohnsonCoric GDP, HermanPoras SB, Ahn KH |title=DisulfideToward bondsan inoptimal bigjoint ET-1recognition areof essentialthe forS1' thesubsites specificof cleavageendothelin atconverting theenzyme-1 Trp(21)ECE-Val(221), bondangiotensin byconverting solubleenzyme endothelin(ACE), convertingand enzyme-1neutral fromendopeptidase baculovirus/insect cells.(NEP) |journal=ArchJ. BiochemMed. BiophysChem. |volume=37345 |issue= 27 |pages= 385–931477–86 |year= 20002002 |pmid= 1062036311906289 |doi= 10.10061021/abbi.1999.1586jm0005454 |display-authors=etal}}

*{{cite journal | authorvauthors=López-OngilMacLeod SKJ, SenchakHusain VRD, SauraGage MDA, ''etAhn al.''K |title=SuperoxideConstitutive regulationphosphorylation of human endothelin-converting enzyme.-1 isoforms |journal=J. Biol. Chem. |volume=275277 |issue= 3448 |pages= 26423–746355–63 |year= 20002003 |pmid= 1083351112244060 |doi= 10.1074/jbc.M000767200M207972200 |doi-access= free }}

*{{cite journal | authorvauthors=HachiyaMuller AL, KobayashiBarret T, Takema YA, ImokawaEtienne GE |title=Biochemical characterizationHeterodimerization of endothelin-converting enzyme-1alpha1 inisoforms culturedregulates skin-derivedthe cellssubcellular and its postulated role in the stimulationdistribution of melanogenesisthis in human epidermis.metalloprotease |journal=J. Biol. Chem. |volume=277278 |issue= 71 |pages= 5395–403545–55 |year= 20022003 |pmid= 1172311312393864 |doi= 10.1074/jbc.M105874200M208949200 |display-authors=etal|doi-access=free }}

*{{cite journal | authorvauthors=InguimbertEckman NEA, CoricWatson PM, PorasMarlow H, ''et al.''L |title=TowardAlzheimer's andisease optimalbeta-amyloid jointpeptide recognitionis ofincreased thein S1'mice subsitesdeficient ofin endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP). |journal=J. MedBiol. Chem. |volume=45278 |issue= 74 |pages= 1477–862081–4 |year= 20022003 |pmid= 1190628912464614 |doi= 10.1074/jbc.C200642200 |display-authors=etal|doi-access=free }}

*{{cite journal | authorvauthors=MacLeodStrausberg KJRL, HusainFeingold RDEA, GageGrouse DA, Ahn KLH |title=ConstitutiveGeneration phosphorylationand initial analysis of humanmore endothelin-convertingthan 15,000 enzymefull-1length isoforms.human and mouse cDNA sequences |journal=JProc. BiolNatl. ChemAcad. Sci. U.S.A. |volume=27799 |issue= 4826 |pages= 46355–6316899–903 |year= 2003 |pmid= 1224406012477932 |doi= 10.10741073/jbcpnas.M207972200242603899 | pmc=139241 |display-authors=etal |bibcode=2002PNAS...9916899M|doi-access=free }}

*{{cite journal | authorvauthors=MullerMasatsugu LK, BarretItoh AH, EtienneChun E, ''et al.''TH |title=HeterodimerizationShear ofstress attenuates endothelin and endothelin-converting enzyme-1 isoformsexpression regulatesthrough theoxidative subcellular distribution of this metalloprotease.stress |journal=JRegul. Biol. ChemPept. |volume=278111 |issue= 11–3 |pages= 545–5513–9 |year= 2003 |pmid= 1239386412609744 |doi= 10.10741016/jbc.M208949200S0167-0115(02)00219-7 |display-authors=etal|hdl=2433/147555 |s2cid=37039969 |hdl-access=free }}

*{{cite journal | authorvauthors=EckmanSmollich EAM, WatsonGötte M, Marlow L,Yip ''et al.''GW |title=Alzheimer'sOn diseasethe beta-amyloidrole peptideof isendothelin-converting increasedenzyme in1 mice(ECE-1) deficientand neprilysin in endothelin-convertinghuman enzyme.breast cancer |journal=J.Breast BiolCancer Res. ChemTreat. |volume=278106 |issue= 43 |pages= 2081–4361–9 |year= 20032007 |pmid= 1246461417295044 |doi= 10.10741007/jbc.C200642200s10549-007-9516-9 |s2cid=5546294 |display-authors=etal}}

*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}

*{{cite journal | author=Masatsugu K, Itoh H, Chun TH, ''et al.'' |title=Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress. |journal=Regul. Pept. |volume=111 |issue= 1-3 |pages= 13–9 |year= 2003 |pmid= 12609744 |doi= }}

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