Conformational dynamics data bank: Difference between revisions

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{{short description|Database of protein conformations}}

{{Multiple issues|wikify = June 2012|dead end = June 2012|orphan = June 2012}}

{{infobox biodatabase

|title = Conformational dynamics data bank

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|laboratory =

|author =

|pmid = PMID 21051356

|released = 2010

|standard =

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|bookmark =

|version=

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}}The '''conformational dynamics data bank''' (CDDB) is a database about conformational dynamics of heavy proteins and protein assemblies.<ref>{{cite journal | quotes = yes|last=Kim|first=Do-Nyun|authorlink=|coauthors=Altschuler Josiah, Strong Campbell, McGill Gaël, Bathe Mark|year=2011|month=Jan|title=Conformational dynamics data bank: a database for conformational dynamics of proteins and supramolecular protein assemblies|journal = Nucleic Acids Res.|volume=39|issue=Database issue|pages=D451-5|publisher= |___location = England| issn = | pmid = 21051356|doi = 10.1093/nar/gkq1088| bibcode = | oclc =| id = | url = | language = eng| format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>

}}The '''conformational dynamics data bank''' ('''CDDB''') is a [[database]] about [[Conformational change|conformational dynamics]] of [[Immunoglobulin heavy chain|heavy proteins]] and [[Protein complex|protein assemblies]]. The CDDB is useful when used alongside static structural data to aid research into [[protein function]]. It is also helpful in identifying protein assemblies that are essential to [[Cell (biology)#Functions|cell function]].<ref name=kim>{{cite journal | quotes = yes|last=Kim|first=Do-Nyun|authorlink=|coauthorsauthor2=Altschuler Josiah, |author3=Strong Campbell, |author4=McGill Gaël, |author5=Bathe Mark |year=2011|monthdate=Jan 2011|title=Conformational dynamics data bank: a database for conformational dynamics of proteins and supramolecular protein assemblies|journal = Nucleic Acids Res.|volume=39|issue=Database issue|pages=D451-5|publisher= |___location = England| issn = | pmid = 21051356|doi = 10.1093/nar/gkq1088| bibcode pmc= | oclc =| id = | url = | language = eng| format = | accessdate = | laysummary = | laysource = | laydate = | quote = 3013685}}</ref>

Analysis is carried out by [[Granularity|coarse-grained computation]] of the structures present in the [[electron microscopy data bank]] (EMDB). This analysis shows [[Thermal fluctuations|equilibrium thermal fluctuations]] and [[Elastic and plastic strain|elastic strain]] energy distributions, which allows for identification of rigid and flexible protein domains. The results also provide information on correlations in [[Database of Molecular Motions|molecular motions]] which can be used to identify molecular regions that are highly coupled dynamically.<ref name=kim/>

==References==

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==External links==

* [https://web.archive.org/web/20110214064241/http://www.cdyn.org/ Data bank website]

[[Category:BiologicalProtein databases]]

[[Category:Protein structure]]