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#REDIRECT [[Cardiac neural crest]]
{{Infobox embryology |
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Latin = complexus cristae neuralis cardiacus |
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Code = [[Terminologia Embryologica|TE]] E4.0.3.5.0.3.1 |
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The FGF8 that is present in the endoderm is regulated by cardiac neural crest-derived cells (Hutson et al., 2006)
he cardiac neural crest, in addition to forming the outflow tract septum, also has an indirect effect on the secondary heart field and thus outflow myocardium development, and that the FGF8 pathway is a common thread between the two populations.
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The '''cardiac neural crest complex''' is a form of [[neural crest]].<ref name="urlThe Neural Crest">{{cite web |url=http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=dbio.section.3109 |title=The Neural Crest |format= |work= |accessdate=2009-05-31}}</ref>
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The '''cardiac neural crest''' develops from the dorsal neural tube.<ref name="pmid18292601">{{cite journal |author=Sun X, Zhang R, Lin X, Xu X |title=Wnt3a regulates the development of cardiac neural crest cells by modulating expression of cysteine-rich intestinal protein 2 in rhombomere 6 |journal=Circ. Res. |volume=102 |issue=7 |pages=831–9 |year=2008 |month=April |pmid=18292601 |doi=10.1161/CIRCRESAHA.107.166488 |url=http://circres.ahajournals.org/cgi/pmidlookup?view=long&pmid=18292601}}</ref> It overlaps the vagal neural crest and migrates to populate the [[pharyngeal arches]] 3, 4 and 6 (producing structures in the head) and to the [[heart]], forming connective tissue that separates the great vessels of the heart.
:''Other Migration Locations:''
:*Into the [[pharyngeal arches]] and [[Truncus arteriosus (embryology)]], forming the [[aorticopulmonary septum]]<ref name="pmid10725237">{{cite journal |author=Jiang X, Rowitch DH, Soriano P, McMahon AP, Sucov HM |title=Fate of the mammalian cardiac neural crest |journal=Development |volume=127 |issue=8 |pages=1607–16 |year=2000 |month=April |pmid=10725237 |doi= |url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=10725237}}</ref> and the [[smooth muscle]] of [[great arteries]].
:*Anterior of the aorta to become the four [[pre-aortic ganglia]] ([[celiac ganglion]], [[superior mesenteric ganglion]], [[inferior mesenteric ganglion]] and [[aortical renal ganglia]])
[[Notch2]] plays an important role in development.<ref name="pmid18330927">{{cite journal |author=Varadkar P, Kraman M, Despres D, Ma G, Lozier J, McCright B |title=Notch2 is required for the proliferation of cardiac neural crest-derived smooth muscle cells |journal=Dev. Dyn. |volume=237 |issue=4 |pages=1144–52 |year=2008 |month=April |pmid=18330927 |doi=10.1002/dvdy.21502}}</ref>
==References==
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{{Development of nervous system}}
[[Category:Embryology of nervous system]]
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