API5: Difference between revisions

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{{Short description|Protein-coding gene in the species Homo sapiens}}

{{orphan|date=December 2008}}

{{Infobox_gene}}

The human [[gene]] '''API5''' encodes the [[protein]] '''Apoptosis inhibitor 5'''.<ref name="pmid9307294">{{cite journal | authorvauthors = Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R | title = AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal | journal = Cancer ResResearch | volume = 57 | issue = 18 | pages = 4063–9 | date =Oct September 1997 | pmid = 9307294 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: API5 apoptosis inhibitor 5| url = httphttps://www.ncbi.nlm.nih.gov/sites/entrezgene?Db=gene&Cmd=ShowDetailView&TermToSearch=8539| accessdate = }}</ref>

This gene encodes an [[apoptosis]] inhibitory protein whose expression prevents apoptosis after [[growth factor]] deprivation. This protein suppresses the [[transcription factor]] [[E2F1]]-induced apoptosis and also interacts with, and negatively regulates acinus, a [[Cell nucleus|nuclear]] factor involved in apoptotic [[DNA]] fragmentation. Its depletion enhances the [[Cytotoxicity|cytotoxic]] action of [[Chemotherapy|chemotherapeutic]] drugs. Crystal structure of API5 exhibited the function for protein-protein interaction <ref>{{cite journal | vauthors = Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI | title = Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules | journal = The Journal of Biological Chemistry | volume = 287 | issue = 14 | pages = 10727–37 | date = March 2012 | pmid = 22334682 | doi = 10.1074/jbc.M111.317594 | pmc = 3322819 | doi-access = free }}</ref>

{{PBB|geneid=8539}}

The human [[gene]] '''API5''' encodes the [[protein]] '''Apoptosis inhibitor 5'''.<ref name="pmid9307294">{{cite journal | author = Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R | title = AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal | journal = Cancer Res | volume = 57 | issue = 18 | pages = 4063–9 |date=Oct 1997 | pmid = 9307294 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: API5 apoptosis inhibitor 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8539| accessdate = }}</ref>

This gene encodes an [[apoptosis]] inhibitory protein whose expression prevents apoptosis after [[growth factor]] deprivation. This protein suppresses the [[transcription factor]] E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a [[Cell nucleus|nuclear]] factor involved in apoptotic [[DNA]] fragmentation. Its depletion enhances the [[Cytotoxicity|cytotoxic]] action of [[Chemotherapy|chemotherapeutic]] drugs.

Diseases associated with API5 include colon [[adenocarcinoma]], and [[cervical cancer]].

API5 functions in nuclear export of mRNA.<ref>{{cite journal | vauthors = Bong SM, Bae SH, Song B, Gwak H, Yang SW, Kim S, Nam S, Rajalingam K, Oh SJ, Kim TW, Park S, Jang H, Lee BI | title = Regulation of mRNA Export Through API5 and Nuclear FGF2 Interaction. | journal = Nucleic Acids Res. | doi = 10.1093/nar/gkaa335 | pmid= 32383752 | year=2020| doi-access = free | volume = 48 | issue = 11 | pmc = 7293033 | pages = 6340–6352 }} </ref>

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== References==

{{reflist}}

== Further reading ==

{{refbegin | 2}}

* {{cite journal | vauthors = Gianfrancesco F, Esposito T, Ciccodicola A, D'Esposito M, Mazzarella R, D'Urso M, Forabosco A | title = Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene | journal = Cytogenetics and Cell Genetics | volume = 84 | issue = 3–4 | pages = 164–6 | year = 1999 | pmid = 10393420 | doi = 10.1159/000015247 | s2cid = 44601647 }}

{{PBB_Further_reading

* {{cite journal | vauthors = Kim JW, Cho HS, Kim JH, Hur SY, Kim TE, Lee JM, Kim IK, Namkoong SE | title = AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis | journal = Laboratory Investigation; A Journal of Technical Methods and Pathology | volume = 80 | issue = 4 | pages = 587–94 | date = April 2000 | pmid = 10780674 | doi = 10.1038/labinvest.3780008 | doi-access = free }}

| citations =

* {{cite journal | authorvauthors =Gianfrancesco FVan den Berghe L, EspositoLaurell TH, CiccodicolaHuez AI, Zanibellato C, Prats H, Bugler B | title =Molecular cloningFIF and[fibroblast finegrowth mappingfactor-2 of API5L1(FGF-2)-interacting-factor], a novelnuclear humanputatively geneantiapoptotic stronglyfactor, relatedinteracts tospecifically anwith antiapoptotic gene.FGF-2 | journal =Cytogenet. CellMolecular Genet.Endocrinology | volume =84 14 | issue = 3-411 | pages = 164–61709–24 |year date = 1999November 2000 | pmid = 1039342011075807 | doi = 10.11591210/000015247me.14.11.1709 |display doi-authorsaccess =etal free }}

* {{cite journal | authorvauthors =Kim JWSutherland HG, ChoMumford HSGK, KimNewton JHK, Ford LV, Farrall R, Dellaire G, Cáceres JF, Bickmore WA | title =AAC Large-11scale overexpressionidentification inducesof invasionmammalian andproteins protectslocalized cervicalto cancernuclear cellssub-compartments from| apoptosis.journal |journal=Lab. Invest.Human Molecular Genetics | volume =80 10 | issue = 418 | pages = 587–941995–2011 |year date = 2000September 2001 | pmid = 1078067411555636 | doi = 10.10381093/labinvesthmg/10.378000818.1995 |display doi-authorsaccess =etal free }}

* {{cite journal | authorvauthors =Van denLi BergheZ, Hu CY, Mo LBQ, LaurellXu HJD, HuezZhao IY | title =FIF [fibroblastEffect growthof factorbeta-2carotene (FGF-2)-interacting-factor],on agene nuclearexpression putativelyof antiapoptoticbreast factor,cancer interactscells] specifically| withjournal FGF-2.= AI Zheng |journal=Mol. Endocrinol.Aizheng = Chinese Journal of Cancer | volume =14 22 | issue = 114 | pages = 1709–24380–4 |year= 2001date |pmid= 11075807April |doi=10.1210/me.14.11.17092003 |display-authors pmid =etal 12703993 }}

* {{cite journal | authorvauthors =Sutherland HGAndersen JS, MumfordLam GKYW, NewtonLeung KAK, |title=Large-scaleOng identificationSE, ofLyon mammalianCE, proteinsLamond localizedAI, toMann nuclearM sub-compartments.| title = Nucleolar proteome dynamics | journal =Hum. Mol. Genet.Nature | volume =10 433 | issue = 187021 | pages = 1995–201177–83 |year date = 2001January 2005 | pmid = 1155563615635413 | doi = 10.10931038/hmg/10nature03207 | bibcode = 2005Natur.18433.1995..77A |display-authors s2cid =etal 4344740 }}

* {{cite journal | authorvauthors =Strausberg RLKim JE, FeingoldTannenbaum EASR, GrouseWhite LHFM | title =Generation andGlobal initial analysisphosphoproteome of more than 15,000 fullHT-length29 human andcolon mouseadenocarcinoma cDNAcells sequences.| |journal =Proc. Natl.Journal Acad.of Sci.Proteome U.S.A.Research | volume =99 4 | issue = 264 | pages = 16899–9031339–46 | year = 20032005 | pmid = 1247793216083285 | doi = 10.10731021/pnas.242603899pr050048h | pmc=139241 |display-authors=etal}}

* {{cite journal | authorvauthors =Li ZOlsen JV, HuBlagoev CYB, MoGnad BQF, Macek B, Kumar C, Mortensen P, Mann M | title =[Effect ofGlobal, beta-carotenein onvivo, geneand expressionsite-specific ofphosphorylation breastdynamics cancerin cells]signaling networks | journal =Ai ZhengCell | volume =22 127 | issue = 43 | pages = 380–4635–48 |year date = 2003November 2006 | pmid = 1270399317081983 | doi = 10.1016/j.cell.2006.09.026 |display s2cid = 7827573 | doi-authorsaccess =etal free }}

* {{cite journal | authorvauthors =Gerhard DSMorris EJ, WagnerMichaud LWA, FeingoldJi EAJY, |title=TheMoon statusNS, qualityRocco JW, andDyson expansionNJ of| thetitle NIH= full-lengthFunctional cDNAidentification project:of theApi5 Mammalianas Genea Collectionsuppressor (MGC).of E2F-dependent apoptosis in vivo | journal =Genome Res.PLOS Genetics | volume =14 2 | issue = 10B11 | pages = 2121–7e196 |year date = 2004November 2006 | pmid = 1548933417112319 | pmc = 1636698 | doi = 10.11011371/grjournal.pgen.25965040020196 | pmc=528928 |displaydoi-authorsaccess =etal free }} {{open access}}

* {{cite journal | vauthors = Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI | title = Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules | journal = J Biol Chem | volume = 287 | pages = 10727–37 | doi = 10.1074/jbc.M111.317594 | pmc = 3322819 | pmid=22334682 | year=2012| issue = 14 | doi-access = free }}

*{{cite journal | author=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |display-authors=etal}}

* {{cite journal | authorvauthors = Bong SM, Bae SH, Song B, Gwak H, Yang SW, Kim JES, TannenbaumNam SRS, WhiteRajalingam FMK, Oh SJ, Kim TW, Park S, Jang H, Lee BI | title =Global phosphoproteome Regulation of HT-29mRNA humanExport colonThrough adenocarcinomaAPI5 cellsand Nuclear FGF2 Interaction. | journal =J. ProteomeNucleic Acids Res. |volume doi =4 10.1093/nar/gkaa335 |issue pmid= 432383752 |pages year=2020| 1339–46doi-access = free |year volume = 200548 |pmid issue = 1608328511 |doi pmc = 10.1021/pr050048h7293033 | pages = 6340–6352 }}

*{{cite journal | author=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}

*{{cite journal | author=Morris EJ, Michaud WA, Ji JY |title=Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. |journal=PLoS Genet. |volume=2 |issue= 11 |pages= e196 |year= 2006 |pmid= 17112319 |doi= 10.1371/journal.pgen.0020196 | pmc=1636698 |display-authors=etal}} {{open access}}

}}

{{refend}}

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