Endothelin converting enzyme 1: Difference between revisions

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{{Short description|Mammalian protein found in Homo sapiens}}

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'''Endothelin converting enzyme 1''', also known as '''ECE1''', is an [[enzyme]] which in humans is encoded by the ''ECE1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ECE1 endothelin converting enzyme 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1889| accessdate = }}</ref><ref name="pmid7805846">{{cite journal | author = Schmidt M, Kröger B, Jacob E, Seulberger H, Subkowski T, Otter R, Meyer T, Schmalzing G, Hillen H | title = Molecular characterization of human and bovine endothelin converting enzyme (ECE-1) | journal = FEBS Lett. | volume = 356 | issue = 2–3 | pages = 238–43 |date=December 1994 | pmid = 7805846 | doi = 10.1016/0014-5793(94)01277-6| url = http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)01277-6 }}</ref><ref name="pmid7864876">{{cite journal | author = Shimada K, Matsushita Y, Wakabayashi K, Takahashi M, Matsubara A, Iijima Y, Tanzawa K | title = Cloning and functional expression of human endothelin-converting enzyme cDNA | journal = Biochem. Biophys. Res. Commun. | volume = 207 | issue = 2 | pages = 807–12 |date=February 1995 | pmid = 7864876 | doi = 10.1006/bbrc.1995.1258 | url = }}</ref>

{{Infobox_gene}}

'''<span lang="fr" dir="ltr">Endothelin</span> converting enzyme 1''', also known as '''ECE1''', is an [[enzyme]] which in humans is encoded by the ''ECE1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ECE1 endothelin converting enzyme 1| url = httphttps://www.ncbi.nlm.nih.gov/sites/entrezgene?Db=gene&Cmd=ShowDetailView&TermToSearch=1889| accessdate = }}</ref><ref name="pmid7805846">{{cite journal | authorvauthors = Schmidt M, Kröger B, Jacob E, Seulberger H, Subkowski T, Otter R, Meyer T, Schmalzing G, Hillen H | title = Molecular characterization of human and bovine endothelin converting enzyme (ECE-1) | journal = FEBS Lett. | volume = 356 | issue = 2–3 | pages = 238–43 |date=December 1994 | pmid = 7805846 | doi = 10.1016/0014-5793(94)01277-6| urldoi-access = http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)01277-6free }}</ref><ref name="pmid7864876">{{cite journal | authorvauthors = Shimada K, Matsushita Y, Wakabayashi K, Takahashi M, Matsubara A, Iijima Y, Tanzawa K | title = Cloning and functional expression of human endothelin-converting enzyme cDNA | journal = Biochem. Biophys. Res. Commun. | volume = 207 | issue = 2 | pages = 807–12 |date=February 1995 | pmid = 7864876 | doi = 10.1006/bbrc.1995.1258 | urldoi-access = free }}</ref>

== Function ==

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==Further reading==

{{refbegin | 2}}

*{{cite journal | authorvauthors=SmollichYorimitsu MK, GötteMoroi MK, YipInagaki GWN |title=OnCloning theand rolesequencing of a human endothelin- converting enzyme 1in renal adenocarcinoma (ECE-1ACHN) andcells neprilysinproducing in human breast cancerendothelin-2 |journal=BreastBiochem. CancerBiophys. Res. TreatCommun. |volume=106208 |issue= 32 |pages= 361–9721–7 |year= 20071995 |pmid= 172950447695628 |doi= 10.10071006/s10549-007-9516-9bbrc.1995.1397 |display-authors=etal}}

{{PBB_Further_reading

*{{cite journal | authorvauthors=MasatsuguSchmidt KM, ItohKröger HB, ChunJacob THE |title=ShearMolecular stresscharacterization attenuatesof endothelinhuman and bovine endothelin- converting enzyme expression through oxidative stress(ECE-1) |journal=Regul.FEBS PeptLett. |volume=111356 |issue= 1–32–3 |pages= 13–9238–43 |year= 20031995 |pmid= 126097447805846 |doi=10.1016/S01670014-01155793(0294)0021901277-76 |display-authors=etal|doi-access=free }}

| citations =

*{{cite journal | authorvauthors=YorimitsuShimada K, MoroiMatsushita KY, InagakiWakabayashi NK |title=Cloning and sequencingfunctional expression of a human endothelin -converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2cDNA |journal=Biochem. Biophys. Res. Commun. |volume=208207 |issue= 2 |pages= 721–7807–12 |year= 1995 |pmid= 76956287864876 |doi= 10.1006/bbrc.1995.1397 1258 |display-authors=etal|doi-access=free }}

*{{cite journal | authorvauthors=SchmidtValdenaire MO, KrögerRohrbacher BE, JacobMattei EMG |title=Molecular characterizationOrganization of humanthe andgene bovineencoding endothelinthe human endothelin-converting enzyme (ECE-1) |journal=FEBSJ. Biol. LettChem. |volume=356270 |issue= 2–350 |pages= 238–4329794–8 |year= 19951996 |pmid= 78058468530372 |doi=10.10161074/0014-5793(94)01277-6jbc.270.50.29794 |displaydoi-authorsaccess=etalfree }}

*{{cite journal | authorvauthors=ShimadaMatsuoka KR, MatsushitaSawamura YT, WakabayashiYamada K |title=CloningHuman andendothelin functionalconverting expressionenzyme ofgene human(ECE1) endothelin-convertingmapped enzymeto cDNAchromosomal region 1p36.1 |journal=BiochemCytogenet. Biophys.Cell Res. CommunGenet. |volume=20772 |issue= 24 |pages= 807–12322–4 |year= 19951996 |pmid= 78648768641140 |doi= 10.10061159/bbrc.1995.1258000134214 |display-authors=etal}}

*{{cite journal | authorvauthors=ValdenaireOrzechowski OHD, RohrbacherRichter ECM, MatteiFunke-Kaiser MGH |title=OrganizationEvidence of thealternative genepromoters encodingdirecting theisoform-specific expression of human endothelin-converting enzyme (ECE-1) mRNA in cultured endothelial cells |journal=J. BiolMol. ChemMed. |volume=27075 |issue= 507 |pages= 29794–8512–21 |year= 19961997 |pmid= 85303729253714 |doi=10.10741007/jbc.270.50.29794s001090050136 |s2cid=34633812 |display-authors=etal}}

*{{cite journal | authorvauthors=MatsuokaSchweizer RA, SawamuraValdenaire TO, YamadaNelböck KP |title=Human endothelin -converting enzyme gene (ECE1ECE-1): mappedthree toisoforms chromosomalwith regiondistinct 1p36.1subcellular localizations |journal=CytogenetBiochem. Cell GenetJ. |volume=72328 |issue= 4 Pt 3|pages= 322–4871–7 |year= 19961998 |pmid= 86411409396733 |doi= 10.11591042/000134214bj3280871| pmc=1218999 |display-authors=etal}}

*{{cite journal | authorvauthors=OrzechowskiKido HDT, RichterSawamura CMT, Funke-KaiserMasaki HT |title=EvidenceThe of alternative promoters directing isoform-specificprocessing expressionpathway of human endothelin-converting enzyme-1 mRNA in cultured endothelial cellsproduction |journal=J. MolCardiovasc. MedPharmacol. |volume=7531 |issuepages= 7S13–5 |pagesyear= 512–211998 |yearissue=Suppl 19971 |pmid= 92537149595387 |doi=10.10071097/s00109005013600005344-199800001-00006 |displaydoi-authorsaccess=etalfree }}

*{{cite journal | authorvauthors=SchweizerHofstra ARM, Valdenaire O, NelböckArch PE |title=HumanA loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1): three isoformsassociated with distinctHirschsprung subcellulardisease, cardiac defects, and autonomic localizationsdysfunction |journal=BiochemAm. J. Hum. Genet. |volume=328 ( Pt 3)64 |issue= 1 Pt 3|pages= 871–7304–8 |year= 19981999 |pmid= 93967339915973 |doi=10.1086/302184 | pmc=12189991377732 |display-authors=etal}}

*{{cite journal | authorvauthors=KidoLee TS, SawamuraLin TM, MasakiMele TA |title=TheProteolytic processing pathway of big endothelin-13 productionby the kell blood group protein |journal=J. Cardiovasc. Pharmacol.Blood |volume=31 Suppl 194 |issue= 4 |pages= S13–51440–50 |year= 19981999 |pmid= 959538710438732 |doi= 10.10971182/00005344blood.V94.4.1440|display-199800001-00006 authors=etal}}

*{{cite journal | authorvauthors=HofstraValdenaire RMO, ValdenaireLepailleur-Enouf OD, ArchEgidy EG |title=A loss-of-functionfourth mutationisoform in theof endothelin-converting enzyme 1 (ECE-1) associatedis withgenerated Hirschsprungfrom disease,an cardiacadditional defects,promoter molecular andcloning autonomicand dysfunctioncharacterization |journal=AmEur. J. Hum. GenetBiochem. |volume=64264 |issue= 12 |pages= 304–8341–9 |year= 1999 |pmid= 991597310491078 |doi=10.10861046/302184 | pmc=1377732j.1432-1327.1999.00602.x |display-authors=etal|doi-access=free }}

*{{cite journal | authorvauthors=LeeFahnoe SDC, LinJohnson MGD, MeleHerman ASB, Ahn K |title=ProteolyticDisulfide processingbonds ofin big endothelinET-31 byare essential for the kellspecific bloodcleavage groupat proteinthe Trp(21)-Val(22) bond by soluble endothelin converting enzyme-1 from baculovirus/insect cells |journal=BloodArch. Biochem. Biophys. |volume=94373 |issue= 42 |pages= 1440–50385–93 |year= 19992000 |pmid= 1043873210620363 |doi= 10.1006/abbi.1999.1586 |display-authors=etal}}

*{{cite journal | authorvauthors=ValdenaireLópez-Ongil OS, Lepailleur-EnoufSenchak DV, EgidySaura GM |title=ASuperoxide fourth isoformregulation of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterization |journal=EurJ. JBiol. BiochemChem. |volume=264275 |issue= 234 |pages= 341–926423–7 |year= 19992000 |pmid= 1049107810833511 |doi= 10.10461074/jjbc.1432-1327.1999.00602.x M000767200 |display-authors=etal|doi-access=free }}

*{{cite journal | authorvauthors=FahnoeHachiya DCA, JohnsonKobayashi GDT, HermanTakema SBY, AhnImokawa KG |title=DisulfideBiochemical bondscharacterization inof bigendothelin-converting ETenzyme-11alpha arein essentialcultured forskin-derived thecells specificand cleavageits atpostulated therole Trp(21)-Val(22)in bondthe bystimulation solubleof endothelinmelanogenesis convertingin enzyme-1human from baculovirus/insect cellsepidermis |journal=ArchJ. BiochemBiol. BiophysChem. |volume=373277 |issue= 27 |pages= 385–935395–403 |year= 20002002 |pmid= 1062036311723113 |doi= 10.10061074/abbijbc.1999.1586M105874200 |doi-access= free }}

*{{cite journal | authorvauthors=López-OngilInguimbert SN, SenchakCoric VP, SauraPoras MH |title=SuperoxideToward regulationan optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP) |journal=J. BiolMed. Chem. |volume=27545 |issue= 347 |pages= 26423–71477–86 |year= 20002002 |pmid= 1083351111906289 |doi= 10.10741021/jbc.M000767200jm0005454 |display-authors=etal}}

*{{cite journal | authorvauthors=HachiyaMacLeod AKJ, KobayashiHusain TRD, TakemaGage YDA, ImokawaAhn GK |title=BiochemicalConstitutive characterizationphosphorylation of human endothelin-converting enzyme-1alpha1 in cultured skin-derived cells and its postulated role in the stimulation of melanogenesis in human epidermisisoforms |journal=J. Biol. Chem. |volume=277 |issue= 748 |pages= 5395–40346355–63 |year= 20022003 |pmid= 1172311312244060 |doi= 10.1074/jbc.M105874200M207972200 |doi-access= free }}

*{{cite journal | authorvauthors=InguimbertMuller NL, CoricBarret PA, PorasEtienne HE |title=Toward an optimal joint recognition of the S1' subsitesHeterodimerization of endothelin -converting enzyme-1 (ECE-1),isoforms angiotensinregulates convertingthe enzymesubcellular (ACE),distribution andof neutralthis endopeptidase (NEP)metalloprotease |journal=J. MedBiol. Chem. |volume=45278 |issue= 71 |pages= 1477–86545–55 |year= 20022003 |pmid= 1190628912393864 |doi= 10.10211074/jm0005454 jbc.M208949200 |display-authors=etal|doi-access=free }}

*{{cite journal | authorvauthors=MacLeodEckman KJEA, HusainWatson RDM, GageMarlow DA, Ahn KL |title=ConstitutiveAlzheimer's phosphorylationdisease ofbeta-amyloid humanpeptide is increased in mice deficient in endothelin-converting enzyme-1 isoforms |journal=J. Biol. Chem. |volume=277278 |issue= 484 |pages= 46355–632081–4 |year= 2003 |pmid= 1224406012464614 |doi= 10.1074/jbc.M207972200C200642200 |display-authors=etal|doi-access=free }}

*{{cite journal | authorvauthors=MullerStrausberg LRL, BarretFeingold AEA, EtienneGrouse ELH |title=HeterodimerizationGeneration ofand endothelin-convertinginitial enzyme-1analysis isoformsof regulatesmore thethan subcellular15,000 distributionfull-length ofhuman and mouse thiscDNA metalloproteasesequences |journal=JProc. BiolNatl. ChemAcad. Sci. U.S.A. |volume=27899 |issue= 126 |pages= 545–5516899–903 |year= 2003 |pmid= 1239386412477932 |doi= 10.10741073/jbcpnas.M208949200242603899 | pmc=139241 |display-authors=etal |bibcode=2002PNAS...9916899M|doi-access=free }}

*{{cite journal | authorvauthors=EckmanMasatsugu EAK, WatsonItoh MH, MarlowChun LTH |title=Alzheimer'sShear diseasestress beta-amyloidattenuates peptide is increased in miceendothelin deficient inand endothelin-converting enzyme expression through oxidative stress |journal=JRegul. Biol. ChemPept. |volume=278111 |issue= 41–3 |pages= 2081–413–9 |year= 2003 |pmid= 1246461412609744 |doi= 10.10741016/jbc.C200642200S0167-0115(02)00219-7 |display-authors=etal|hdl=2433/147555 |s2cid=37039969 |hdl-access=free }}

*{{cite journal | authorvauthors=StrausbergSmollich RLM, FeingoldGötte EAM, GrouseYip LHGW |title=GenerationOn andthe initial analysisrole of moreendothelin-converting thanenzyme 15,0001 full(ECE-length human1) and mouseneprilysin cDNAin sequenceshuman breast cancer |journal=Proc.Breast Natl.Cancer AcadRes. Sci. U.S.ATreat. |volume=99106 |issue= 263 |pages= 16899–903361–9 |year= 20032007 |pmid= 1247793217295044 |doi= 10.10731007/pnas.242603899 s10549-007-9516-9 | pmcs2cid=1392415546294 |display-authors=etal}}

*{{cite journal | author=Masatsugu K, Itoh H, Chun TH |title=Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress |journal=Regul. Pept. |volume=111 |issue= 1–3 |pages= 13–9 |year= 2003 |pmid= 12609744 |doi=10.1016/S0167-0115(02)00219-7 |display-authors=etal}}

*{{cite journal | author=Smollich M, Götte M, Yip GW |title=On the role of endothelin-converting enzyme 1 (ECE-1) and neprilysin in human breast cancer |journal=Breast Cancer Res. Treat. |volume=106 |issue= 3 |pages= 361–9 |year= 2007 |pmid= 17295044 |doi= 10.1007/s10549-007-9516-9 |display-authors=etal}}

}}

{{refend}}

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