Transporter Classification Database: Difference between revisions

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{{Short description|Classification of membrane proteins including ion channels}}

The '''Transporter Classification Database''' (or '''TCDB''') is an [[International Union of Biochemistry and Molecular Biology]] (IUBMB)-approved classification system for [[membrane transport protein]]s, including [[ion channel]]s.<ref>{{cite journal|last1=Saier|first1=Milton H.|last2=Reddy|first2=Vamsee S.|last3=Tamang|first3=Dorjee G.|last4=Västermark|first4=Åke|title=The Transporter Classification Database|journal=Nucleic Acids Research|date=January 2014|volume=42|issue=D1|pages=D251–D258|doi=10.1093/nar/gkt1097|pmid=24225317|url=http://nar.oxfordjournals.org/content/42/D1/D251 |accessdatepmc=1 March 20163964967}}</ref><ref>{{cite journal|last1=Saier|first1=M. H.|last2=Yen|first2=M. R.|last3=Noto|first3=K.|last4=Tamang|first4=D. G.|last5=Elkan|first5=C.|title=The Transporter Classification Database: recent advances|journal=Nucleic Acids Research|date=1 January 2009|volume=37|issue=Database|pages=D274–D278|doi=10.1093/nar/gkn862|url=http://nar.oxfordjournals.org/content/37/suppl_1/D274 |accessdatepmid=1 March 201619022853|pmc=2686586}}</ref><ref>{{cite journal|last1=Saier|first1=M. H.|last2=Tran|first2=C. V.|last3=Barabote|first3=R. D.|title=TCDB: the Transporter Classification Database for membrane transport protein analyses and information|journal=Nucleic Acids Research|date=1 January 2006|volume=34|issue=90001|pages=D181–D186|doi=10.1093/nar/gkj001|url=http://nar.oxfordjournals.org/content/34/suppl_1/D181 |accessdatepmid=1 March 201616381841|pmc=1334385}}</ref>

==Classification==

Line 8 ⟶ 9:

====1.A α-type channels====

* 1.A.1 [[Voltage-gated ion channel|Voltage-gated ion channel superfamily]]

* 1.A.2 I[[inward-rectifier K+ channel|nwardInward-rectifier K⁺ channel family]]

* 1.A.3 [[Ryanodine-inositol-1,4,5-trisphosphate receptor Ca2+ channel|Ryanodine-inositol-1,4,5-trisphosphate receptor Ca²⁺ channel family]]

* 1.A.4 [[Transient receptor potential Ca2+ channel|Transient receptor potential Ca²⁺ channel family]]

Line 42 ⟶ 43:

* 1.A.34 [[Bacillus gap junction-like channel-forming complex family|''Bacillus'' gap junction-like channel-forming complex family]]

* 1.A.35 [[CorA metal ion transporter|CorA metal ion transporter family]]

* 1.A.36 [[Intracellular chlorideChloride channel#CLIC family|Intracellular chloride channel family]]

* 1.A.37 [[The CD20 Ca2+ channel family|CD20 Ca²⁺ channel family]]

* 1.A.38 [[The Golgi pH regulator family|Golgi pH regulator family]]

* 1.A.39 [[Type C Influenza Virus CM2 Channel (CM2-C) Family|Type C influenza virus CM2 channel family]]

* 1.A.40 [[Human Immunodeficiency Virus Type I, HIV-1 (Retrovirdiac) Vpu Channel (Vpu-C) Familyprotein|Human immunodeficiency virus type I, HIV-1 (retrovirdiac) Vpu channel family]]

* 1.A.41 [[Avian reovirus p10 Vvroporin family]]

* 1.A.42 [[HIV viral protein R family]]

Line 57 ⟶ 58:

* 1.A.49 [[Human coronavirus ns12.9 viroporin family]]

* 1.A.50 [[phospholamban|Phospholamban (Ca²⁺-channel and Ca²⁺-ATPase regulator) family]]

*1.A.51 The Voltage-gated Proton Channel (VPC) Family

*1.A.52 The Ca²⁺ Release-activated Ca²⁺ (CRAC) Channel (CRAC-C) Family

*1.A.53 The Hepatitis C Virus P7 Viroporin Cation-selective Channel (HCV-P7) Family

*1.A.54 The Presenilin ER Ca²⁺ Leak Channel (Presenilin) Family

*1.A.55 The Synaptic Vesicle-Associated Ca²⁺ Channel, Flower (Flower) Family

*1.A.56 The Copper Transporter (Ctr) Family

*1.A.57 The Human SARS Coronavirus Viroporin (SARS-VP)

*1.A.58 The Type B Influenza Virus Matrix Protein 2 (BM2-C) Family

*1.A.59 The Bursal Disease Virus Pore-Forming Peptide, Pep46 (Pep46) Family

*1.A.60 The Mammalian Reovirus Pre-forming Peptide, Mu-1 (Mu-1) Family

*1.A.61 The Insect Nodavirus Channel-forming Chain F (Gamma-Peptide) Family

*1.A.62 The Homotrimeric Cation Channel (TRIC) Family

*1.A.63 The Ignicoccus Outer Membrane α-helical Porin (I-OMP Family

*1.A.64 The Plasmolipin (Plasmolipin) Family

*1.A.65 The Coronavirus Viroporin E Protein (Viroporin E) Family

*1.A.66 The Pardaxin (Pardaxin) Family

*1.A.67 The Membrane Mg²⁺ Transporter (MMgT) Family

*1.A.68 The Viral Small Hydrophobic Viroporin (V-SH) Family

*1.A.69 The Heteromeric Odorant Receptor Channel (HORC) Family

*1.A.70 The Molecule Against Microbes A (MamA) Family

*1.A.71 The Brain Acid-soluble Protein Channel (BASP1 Channel) Family

*1.A.72 The Mer Superfamily

*1.A.73 The Colicin Lysis Protein (CLP) Family

*1.A.74 The Mitsugumin 23 (MG23) Family

*1.A.75 The Mechanical Nociceptor, Piezo (Piezo) Family

*1.A.76 The Magnesium Transporter1 (MagT1) Family

*1.A.77 The Mg²⁺/Ca²⁺ Uniporter (MCU) Family

*1.A.78 The K⁺-selective Channel in Endosomes and Lysosomes (KEL) Family

*1.A.79 The Cholesterol Uptake Protein (ChUP) or Double Stranded RNA Uptake Family

*1.A.80 The NS4a Viroporin (NS4a) Family

*1.A.81 The Low Affinity Ca²⁺ Channel (LACC) Family

*1.A.82 The Hair Cell Mechanotransduction Channel (HCMC) Family

*1.A.83 The SV40 Virus Viroporin VP2 (SV40 VP2) Family

*1.A.84 The Calcium Homeostasis Modulator Ca²⁺ Channel (CALHM-C) Family

*1.A.85 The Poliovirus 2B Viroporin (2B Viroporin) Family

*1.A.86 The Human Papilloma Virus type 16 (HPV16) L2 Viroporin (L2 Viroporin) Family

*1.A.87 The Mechanosensitive Calcium Channel (MCA) Family

*1.A.88 The Fungal Potassium Channel (F-Kch) Family

*1.A.89 The Human Coronavirus 229E Viroporin (229E Viroporin) Family

*1.A.90 The Human Metapneumovirus (HMPV) Viroporin (HMPV-Viroporin) Family

*1.A.91 The Cytoadherence-linked Asexual Protein 3.2 of Plasmodium falciparum (Clag3) Family

*1.A.92 The Reovirus Viroporin VP10 (RVP10) Family

*1.A.93 The Bluetongue Virus Non-Structural Protein 3 Viroporin (NS3) Family

*1.A.94 The Rotavirus Non-structural Glycoprotein 4 Viroporin (NSP4) Family

*1.A.95 The Ephemerovirus Viroporin (EVVP) Family

*1.A.96 The Human Polyoma Virus Viroporin (PVVP) Family

*1.A.97 The Human Papillomavirus type 16 E5 Viroporin (HPV-E5) Family

*1.A.98 Human T-Lymphotropic Virus 1 P13 protein (HTLV1-P13) Family

*1.A.99 The Infectious Bronchitis Virus Envelope Small Membrane Protein E (IBV-E) Family

*1.A.100 The Rhabdoviridae Putative Viroporin, U5 (RV-U5) Family

*1.A.101 The Peroxisomal Pore-forming Pex11 (Pex11) Family

*1.A.102 Influenza A viroporin PB1-F2 (PB1-F2) Family

*1.A.103 The Simian Virus 5 (Parainfluenza Virus 5) SH (SV5-SH) Family

*1.A.104 The Proposed Flagellar Biosynthesis Na⁺ Channel, FlaH (FlaH) Family

*1.A.105 The Mixed Lineage Kinase Domain-like (MLKL) Family

*1.A.106 The Calcium Load-activated Calcium Channel (CLAC) Family

*1.A.107 The Pore-forming Globin (Globin) Family

====1.B. [[Porin (protein)|β-Barrel porins]] and other outer membrane proteins====

* 1.B.1 [[General bacterial porin family]]

* 1.B.2 [[Chlamydia (genusbacterium)|Chlamydial]] porin (CP) family

* 1.B.3 [[Maltoporin|Sugar porin]] (SP) family

* 1.B.4 [[Brucella-Rhizobium porin]] (BRP) family

Line 83 ⟶ 141:

* 1.B.23 Cyanobacterial porin (CBP) family

* 1.B.24 [[Mycobacterial porin]]

* 1.B.25 [[Outer membrane porin D|Outer membrane porin (Opr) family]]

* 1.B.26 Cyclodextrin porin (CDP) family

* 1.B.31 [[Campylobacter jejuni]] major outer membrane oorinporin (MomP) family

* 1.B.32 Fusobacterial outer membrane porin (FomP) family

* 1.B.33 Outer membrane protein insertion porin (Bam complex) (OmpIP) family

Line 95 ⟶ 153:

* 1.B.44 Probable protein translocating porphyromonas gingivalis porin (PorT) family

* 1.B.49 Anaplasma P44 (A-P44) porin family

* 1.B.48 Curli-like transporters<ref>[http://opm.phar.umich.edu/families.php?superfamily=503]</ref>

* 1.B.54 [[Intimin]]/Invasin (Int/Inv) or [[Autotransporter ___domain|Autotransporter-3]] family

* 1.B.55 Poly-acetyl-D-glucosamine porin (PgaA) family<ref>[http://opm.phar.umich.edu/families.php?superfamily=545]</ref>

* 1.B.57 Legionella major-outer membrane protein (LM-OMP) family

* 1.B.60 Omp50 porin (Omp50 Porin) family

Line 108 ⟶ 166:

* 1.B.71 Proteobacterial/verrucomicrobial porin (PVP) family

* 1.B.72 Protochlamydial outer membrane porin (PomS/T) family

* 1.B.73 Capsule biogenesis/assembly (CBA) family<ref>[http://opm.phar.umich.edu/families.php?superfamily=476]</ref>

* 1.B.78 DUF3374 electron transport-associated porin (ETPorin) family

Line 123 ⟶ 181:

* 1.C.56 [[HrpZ Family|''Pseudomonas syringae'' HrpZ cation channel family]]

* 1.C.57 [[Clostridial Cytotoxin family|Clostridial cytotoxin family]]

*1.C.58 [[Microcin|The Microcin E492/C24 (Microcin E492) Family]]

* 1.C.74 [[Snake venom|Snake cytotoxin]] (SCT) family

* 1.C.97 [[Pleurotolysin|Pleurotolysin pore-forming family]]

Line 132 ⟶ 191:

* 1.D.4 The Tolaasin Channel-forming Family

* 1.D.5 The [[Alamethicin]] or [[Peptaibol]] Antibiotic Channel-forming Family

* 1.D.6 The Complexed Poly 3-Hydroxybutyrate Ca2Ca²⁺ Channel (cPHB-CC) Family

* 1.D.7 The Beticolin Family

* 1.D.8 The [[Saponin]] Family

Line 145 ⟶ 204:

* 1.D.17 Combinatorially-designed, Pore-forming, β-sheet Peptide Family

* 1.D.18 The Pore-forming Guanosine-Bile Acid Conjugate Family

* 1.D.19 Ca2Ca²⁺ Channel-forming Drug, [[Digitoxin]] Family

* 1.D.20 The Pore-forming Polyene Macrolide Antibiotic/fungal Agent (PMAA) Family

* 1.D.21 The Lipid Nanopore (LipNP) Family

Line 186 ⟶ 245:

* 1.D.58 The Anion Transporting Prodigiosene (Prodigiosene) Family

* 1.D.59 The Anion Transporting Perenosin (Perenosin) Family

* 1.D.60 The Alpha,Gamma-CycicCyclic Peptide (AGCP) Family

* 1.D.61 The Anionophoric {{Chem name|2,6-Bis(Benzimidazol-2-yl)Pyridine}} (ABBP) Family

* 1.D.62 The Bis-Triazolyl DiGuanosine Derivative Channel-forming (TDG) Family

* 1.D.63 The Peptide-based Nanopore (PepNP) Family

Line 244 ⟶ 303:

====2.A Porters ([[uniporter]]s, [[symporter]]s, [[antiporter]]s)====

{{see also|Amino acid transporter}}

*2.A.1 [[Major facilitator superfamily|Major Facilitator superfamily]] (MFS), see also [[Lactose permease]], [[Phosphate permease]] and [[Glucose transporter]]

Line 250 ⟶ 309:

*2.A.3 [[APC superfamily|The Amino Acid-Polyamine-Organocation (APC) Family]]

*2.A.4 [[Cation diffusion facilitator]] (CDF) Family

*2.A.5 [[Ferroportin|Zinc (Zn2Zn²⁺)-Iron (Fe2Fe²⁺) Permease]] Family<ref>[http://opm.phar.umich.edu/families.php?family=873]</ref>

*2.A.6 [[Resistance-nodulation-cell division superfamily|Resistance-Nodulation-Cell Division Superfamily]], see also [[SecDF protein-export membrane protein]]

*2.A.7 The [[Small multidrug resistance protein|Drug/Metabolite Transporter]] (DMT) Superfamily

*2.A.8 The Gluconate:H⁺ Symporter (GntP) Family

*2.A.9 The Membrane Protein Insertase (YidC/Alb3/Oxa1) Family

*2.A.10 The 2-Keto-3-Deoxygluconate Transporter (KdgT) Family

*2.A.11 The Citrate-Mg2Mg²⁺:H⁺ (CitM) Citrate-Ca2Ca²⁺:H⁺ (CitH) Symporter (CitMHS) Family

*2.A.12 [[ATP:ADP antiporter family|ATP:ADP Antiporter Family]]

*2.A.13 The C4-Dicarboxylate Uptake (Dcu) Family

*2.A.14 [[Lactate permease family|Lactate Permease Family]]

*2.A.15 [[Betaine transporter|The Betaine/Carnitine/Choline Transporter (BCCT) Family]]

*2.A.16 [[Tellurite-resistance/dicarboxylate transporter|TeluriteTellurite-resistance/Dicarboxylate Transporter]] Family

*2.A.17 [[Proton-dependent oligopeptide transporter|Proton-dependent Oligopeptide Transporter Family]]

*2.A.18 The Amino Acid/Auxin Permease (AAAP) Family

*2.A.19 The Ca2Ca²⁺:Cation Antiporter (CaCA) Family

*2.A.20 The Inorganic Phosphate Transporter (PiT) Family

*2.A.21 [[Sodium-solute symporter|Solute:Sodium Symporter Family]]

*2.A.22 The [[Neurotransmitter sodium symporter|Neurotransmitter:Sodium Symporter]] Family

*2.A.23 The Dicarboxylate/Amino Acid:Cation (Na⁺ or H⁺) Symporter (DAACS) Family

*2.A.24 The 2-Hydroxycarboxylate Transporter (2-HCT) Family

*2.A.25 [[AGCS family|Alanine or Glycine:Cation Symporter]] (AGCS) Family

*2.A.26 The Branched Chain Amino Acid:Cation Symporter (LIVCS) Family

*2.A.27 The Glutamate:Na⁺ Symporter (ESS) Family

*2.A.28 [[Bile acid:sodium symporter|Bile Acid:Na⁺ Symporter]] Family

*2.A.29 [[Mitochondrial carrier]] Family

*2.A.30 [[Chloride potassium symporter|Cation-Chloride Cotransporter]] (CCC) Family

*2.A.31 [[Anion exchanger family|Anion Exchanger]] Family]]

*2.A.32 The Silicon Transporter (Sit) Family

*2.A.33 [[Sodium-proton antiporter|NhaA Na⁺:H⁺ Antiporter]] (NhaA) Family

*2.A.34 The NhaB Na⁺:H⁺ Antiporter (NhaB) Family

*2.A.35 The NhaC Na⁺:H⁺ Antiporter (NhaC) Family

*2.A.36 [[Monovalent cation:proton antiporter-1|Monovalent Cation:Proton Antiporter-1]] (CPA1) Family

*2.A.37 [[Monovalent cation:proton antiporter-32|Monovalent Cation:Proton Antiporter-2]] (CPA2) Family

*2.A.38 [[Potassium transporter family|K⁺ Transporter (Trk)]] Family

*2.A.39 [[Nucleobase cation symporter-1|Nucleobase:Cation Symporter-1]] (NCS1) Family

*2.A.40 [[Nucleobase cation symporter-2|Nucleobase:Cation Symporter-2]] (NCS2) Family

Line 290 ⟶ 349:

*2.A.43 The Lysosomal Cystine Transporter (LCT) Family

*2.A.45 [[Arsenite-antimonite transporter|Arsenite-Antimonite Efflux Family]]

*2.A.46 The Benzoate:H⁺ Symporter (BenE) Family

*2.A.47 [[Divalent anion–sodium symporter|Divalent Anion:Na⁺ Symporter]] (DASS) Family

*2.A.48 The Reduced Folate Carrier (RFC) Family

*2.A.49 [[Chloride channel|Chloride Carrier/Channel]] (ClC) Family

*2.A.50 The Glycerol Uptake (GUP) Family

*2.A.51 The Chromate Ion Transporter (CHR) Family

*2.A.52 The Ni2Ni²⁺-Co2Co²⁺ Transporter (NiCoT) Family

*2.A.53 [[Sulfate permease]] (SulP) Family

*2.A.54 The Mitochondrial Tricarboxylate Carrier (MTC) Family

*2.A.55 [[Natural Resistance-Associated Macrophage Proteins|The Metal Ion (Mn2Mn²⁺-iron) Transporter]] (Nramp) Family

*2.A.56 The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family

*2.A.57 The Equilibrative Nucleoside Transporter (ENT) Family

*2.A.58 The Phosphate:Na⁺ Symporter (PNaS) Family

*2.A.59 The Arsenical Resistance-3 (ACR3) Family

*2.A.60 [[Organo anion transporter family|Organo Anion Transporter]] (OAT) Family

*2.A.61 The C4-dicarboxylate Uptake C (DcuC) Family

*2.A.62 The NhaD Na⁺:H⁺ Antiporter (NhaD) Family

*2.A.63 [[Monovalent cation:proton antiporter-3|The Monovalent Cation (K⁺ or Na⁺):Proton Antiporter-3]] (CPA3) Family

*2.A.64 [[Twin-arginine translocation pathway|Twin Arginine Targeting (Tat) Family]]

*2.A.65 The Bilirubin Transporter (BRT) Family

Line 314 ⟶ 373:

*2.A.68 The p-Aminobenzoyl-glutamate Transporter (AbgT) Family

*2.A.69 The Auxin Efflux Carrier (AEC) Family

*2.A.70 The Malonate:Na⁺ Symporter (MSS) Family

*2.A.71 The Folate-Biopterin Transporter (FBT) Family

*2.A.72 The K⁺ Uptake Permease (KUP) Family

*2.A.73 The Short Chain Fatty Acid Uptake (AtoE) Family

*2.A.74 The 4 TMS Multidrug Endosomal Transporter (MET) Family

Line 327 ⟶ 386:

*2.A.81 The Aspartate:Alanine Exchanger (AAEx) Family

*2.A.82 The Organic Solute Transporter (OST) Family

*2.A.83 The Na⁺-dependent Bicarbonate Transporter (SBT) Family

*2.A.84 The Chloroplast Maltose Exporter (MEX) Family

*2.A.85 The Aromatic Acid Exporter (ArAE) Family

Line 340 ⟶ 399:

*2.A.95 The 6TMS Neutral Amino Acid Transporter (NAAT) Family

*2.A.96 The Acetate Uptake Transporter (AceTr) Family

*2.A.97 The Mitochondrial Inner Membrane K⁺/H⁺ and Ca2Ca²⁺/H⁺ Exchanger (LetM1) Family

*2.A.98 The Putative Sulfate Exporter (PSE) Family

*2.A.99 The 6TMS Ni2Ni²⁺ uptake transporter (HupE-UreJ) Family

*2.A.100 The Ferroportin (Fpn) Family

*2.A.101 The Malonate Uptake (MatC) Family (Formerly UIT1)

Line 349 ⟶ 408:

*2.A.104 The L-Alanine Exporter (AlaE) Family

*2.A.105 The Mitochondrial Pyruvate Carrier (MPC) Family

*2.A.106 The Ca2Ca²⁺:H⁺ Antiporter-2 (CaCA2) Family

*2.A.107 The MntP Mn2Mn²⁺ exporterExporter (MntP) Family

*2.A.108 The Iron/Lead Transporter (ILT) Family

*2.A.109 The Tellurium Ion Resistance (TerC) Family

*2.A.110 The hemeHeme transporterTransporter, heme-responsive gene protein (HRG) Family

*2.A.111 The Na⁺/H⁺ Antiporter-E (NhaE) Family

*2.A.112 The KX Blood-group Antigen (KXA) Family

*2.A.113 The Nickel/cobalt Transporter (NicO) Family

Line 365 ⟶ 424:

*2.A.120 The Putative Amino Acid Permease (PAAP) Family

*2.A.121 The Sulfate Transporter (CysZ) Family

*2.A.122 The LrgB/CidB holin-like auxilaryauxiliary protein (LrgB/CidB) Family

*2.A.123 The Sweet; PQ-loop; Saliva; MtN3 (Sweet) Family

*2.A.124 The Lysine Exporter (LysO) Family

Line 382 ⟶ 441:

*2.B.8 The [[Bafilomycin]] A1 (Bafilomycin) Family

*2.B.9 The [[Cell Penetrating Peptide]] (CPP) Functional Family

*2.B.10 The Synthetic CPP, [[Transportan]] Family

*2.B.11 The [[Calcimycin]] or A23187 Carrier-type Ionophore Family

*2.B.12 The [[Salinomycin]] Family

Line 389 ⟶ 448:

*2.B.15 The Tris-thiourea Tripodal-based Chloride Carrier (TTT-CC) Family

*2.B.16 The Halogen-bond-containing Compound Anion Carrier (HCAC) Family

*2.B.17 The Isophthalaminde Derivative H⁺:Cl-⁻ Co-transporter (IDC) Family

*2.B.18 The Pyridine-2,6-Dicarboxamine Derivative (PDCA) H+:Cl-⁻ Co-transporter Family

*2.B.19 The Calix(4)pyrrole Derivative (C4P) Family

*2.B.20 The Prodigiosin (Prodigiosin) Chloride/Bicarbonate Exchanger Family

*2.B.21 The ortho-Phenylenediamine-bis-Urea Derivative Anion Transporter (oPDA-U) Family

*2.B.22 The Imidazolium-functionalized Anion Transporter (IAT) Family

*2.B.23 The Homotetrameric Transmembrane Zn2Zn<sup>2+</Co2sup>/Co²⁺:Proton Synthetic Antiporter, Rocker (Rocker) Family

*2.B.24 The {{Chem name|2,6-Bis(benzimidazol-2-yl)pyridine}} Anion Carrier (BBP-AC) Family

*2.B.25 The Peptide-mediated Lipid Flip-Flop (PLFF) Family

*2.B.26 The {{Not a typo|Bis(imidazolyl)-functionalized}} {{Not a typo|Bis(Choloyl)}} Conjugate (BIBCC) Family

*2.B.27 The Tris-Urea Anion Transporter Family

*2.B.29 The Anionophoric Marine Alkaloid [[Tambjamine]] Family

Line 405 ⟶ 464:

*2.C.1 The TonB-ExbB-ExbD/TolA-TolQ-TolR (TonB) Family of Auxiliary Proteins for Energization of Outer Membrane Receptor (OMR)-mediated Active Transport

===3. [[Primary active transport|Primary active transporters]]ers===

====3.A. P-P-bond hydrolysis-driven transporters====

*3.A.1 [[ABC transporter]]s including BtuCD, molybdate uptake transporter, [[Cystic fibrosis transmembrane conductance regulator]] and others

*3.A.2 The H⁺- or Na⁺-translocating [[F-type ATPase]], [[V-type ATPase]] and A-type ATPase (F-ATPase) Superfamilysuperfamily

*3.A.3 [[P-type ATPase|The P-type ATPase]] Superfamily

*3.A.4 [[ArsB and ArsAB transporters|The Arsenite-Antimonite (ArsAB) Effluxefflux]] Familyfamily

*3.A.5 [[SecY protein|General secretory pathway]] (Sec) [[translocon]] (preprotein translocase SecY)

*3.A.6 The Type III (Virulence-related) Secretory Pathway (IIISP) Family

Line 417 ⟶ 476:

*3.A.8 The Mitochondrial Protein Translocase (MPT) Family

*3.A.9 The Chloroplast Envelope Protein Translocase (CEPT or Tic-Toc) Family

*3.A.10 The [[H+, Na+-translocating Pyrophosphatasepyrophosphatase (Mfamily|H⁺, Na⁺-PPase)translocating Pyrophosphatase]] Familyfamily

*3.A.11 The Bacterial Competence-related DNA Transformation Transporter (DNA-T) Family

*3.A.12 The Septal DNA Translocator (S-DNA-T) Family

Line 436 ⟶ 495:

====3.B Decarboxylation-driven transporters====

*3.B.1 The Na⁺-transporting Carboxylic Acid Decarboxylase (NaT-DC) Family

====3.C Methyltransfer-driven transporters====

*3.C.1 The Na⁺ Transporting Methyltetrahydromethanopterin:Coenzyme M Methyltransferase (NaT-MMM) Family

====3.D. Oxidoreduction-driven transporters====

They include a number of transmembrane [[cytochrome b]]-like proteins including [[coenzyme Q - cytochrome c reductase]] (cytochrome bc1 ); [[cytochrome b6f complex]]; formate dehydrogenase, respiratory [[nitrate reductase]]; [[succinate - coenzyme Q reductase]] (fumarate reductase); and [[succinate dehydrogenase]]. See [[electron transport chain]].

*3.D.1 [[NADH:ubiquinone reductase (H+-translocating)|The H⁺ or Na⁺-translocating NADH Dehydrogenase]] ("complex I") family

*3.D.2 The Proton-translocating Transhydrogenase (PTH) Family

*3.D.3 [[Cytochrome c nitrite reductase|The Proton-translocating Quinol:Cytochrome c Reductase]]) Superfamily

*3.D.4 [[Cytochrome c oxidase|Proton-translocating Cytochrome Oxidase]] (COX) Superfamily

*3.D.5 The Na⁺-translocating NADH:Quinone Dehydrogenase (Na-NDH or NQR) Family

*3.D.6 The Putative Ion (H⁺ or Na⁺)-translocating NADH:Ferredoxin Oxidoreductase (NFO or RNF) Family

*3.D.7 The H2H₂:Heterodisulfide Oxidoreductase (HHO) Family

*3.D.8 The Na⁺- or H⁺-Pumping Formyl Methanofuran Dehydrogenase (FMF-DH) Family

*3.D.9 The H⁺-translocating F420H2 Dehydrogenase (F420H2DH) Family

*3.D.10 The Prokaryotic Succinate Dehydrogenase (SDH) Family

Line 470 ⟶ 529:

*4.A.4 The PTS Glucitol (Gut) Family

*4.A.5 The PTS Galactitol (Gat) Family

*4.A.6 [[PTS Mannose-Fructose-Sorbose Family|The PTS Mannose-Fructose-Sorbose (Man) Family]]

*4.A.7 The PTS L-Ascorbate (L-Asc) Family

Line 496 ⟶ 555:

====5.B Transmembrane 1-electron transfer carriers====

*5.B.1 The Phagocyte ([[gp91phox]]) [[NADPH oxidase|NADPH Oxidase]] Family

*5.B.2 The Eukaryotic [[Cytochrome b561]] (Cytb561) Family

*5.B.3 The Geobacter Nanowire Electron Transfer (G-NET) Family

*5.B.4 The Plant Photosystem I Supercomplex (PSI) Family

*5.B.5 The Extracellular Metal Oxido-Reductase (EMOR) Family

*5.B.6 The [[STEAP3|Transmembrane Epithelial Antigen ProtienProtein-3]] Ferric Reductase (STEAP) Family

*5.B.7 The [[YedZ family|YedZ (YedZ) Family]]

*5.B.8 The Trans-Outer Membrane Electron Transfer Porin/Cytochrome Complex (ET-PCC) Family

*5.B.9 The Porin-Cytochrome c (Cyc2) Family

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* [http://www.tcdb.org/ Transporter Classification Database]

* [http://www.chem.qmul.ac.uk/iubmb/mtp/ List] at qmul.ac.uk

* {{cite journal |vauthors=Saier MH, Tran CV, Barabote RD |title=TCDB: the Transporter Classification Database for membrane transport protein analyses and information |journal=Nucleic Acids Res. |volume=34 |issue=Database issue |pages=D181–6 |date=January 2006 |pmid=16381841 |pmc=1334385 |doi=10.1093/nar/gkj001 |url=http://nar.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=16381841}}

* {{cite journal |vauthors=Busch W, Saier MH |title=The transporter classification (TC) system, 2002 |journal=Crit. Rev. Biochem. Mol. Biol. |volume=37 |issue=5 |pages=287–337 |year=2002 |pmid=12449427 |doi= 10.1080/10409230290771528|urls2cid=10558982 }}

* [http://www.guidetopharmacology.org/GRAC/ReceptorFamiliesForward?type=TRANSPORTER Classification of human transporters in pharmacology]

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{{Oxidoreduction-driven transporters}}

[[Category:BiologicalBiochemistry databases]]

[[Category:Transport proteins]]

[[Category:Transmembrane proteins]]

[[Category:ClassificationProtein systemsclassification]]

[[Category:Biological databases]]