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Rodents that eat transformation DNA get that DNA in their phagocytes, mostly, and lesser amounts in their other cells. (Bacterial and M13 DNA.) This DNA is thought to provoke phagocytosis, so that seems believable. However, no gene expression therefrom, and none is expected to be possible. From Goldstein et al 2005 and Lemaux 2008. |
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Insertional mutagenesis (but not lethal for the plant cell – as the organism is diploid)
Transformation DNA fed to rodents ends up in their [[phagocyte]]s and rarely other cells. Specifically this is bacterial and [[M13 bacteriophage|M13]] DNA. (This preferential accumulation in phagocytes is thought to be real and not a detection artifact, since these DNA extents are thought to provoke [[phagocytosis]].) However no [[gene expression]] is known to have resulted, and this is not thought to be possible.<ref name="Goldstein-et-al-2005">{{cite journal | last=Goldstein | first=Daniel A. | last2=Tinland | first2=Bruno | last3=Gilbertson | first3=Lawrence A. | last4=Staub | first4=J.M. | last5=Bannon | first5=G.A. | last6=Goodman | first6=R.E. | last7=McCoy | first7=R.L. | last8=Silvanovich | first8=A. | title=Human safety and genetically modified plants: a review of antibiotic resistance markers and future transformation selection technologies | journal=[[Journal of Applied Microbiology]] | publisher=[[Society for Applied Microbiology]] ([[Wiley Publishing|Wiley]]) | volume=99 | issue=1 | year=2005 | issn=1364-5072 | doi=10.1111/j.1365-2672.2005.02595.x | pages=7–23}}</ref><ref name="Lemaux-2008">{{cite journal | last=Lemaux | first=Peggy G. | title=Genetically Engineered Plants and Foods: A Scientist's Analysis of the Issues (Part I) | journal=[[Annual Review of Plant Biology]] | publisher=[[Annual Reviews (publisher)|Annual Reviews]] | volume=59 | issue=1 | year=2008 | issn=1543-5008 | doi=10.1146/annurev.arplant.58.032806.103840 | pages=771–812 | pmid=18284373}}</ref>
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