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The genetic basis of auricular hypertrichosis has not been settled. Some researchers have proposed a Y-linked pattern of inheritance and others have suggested an autosomal gene is responsible. A third hypothesis predicts the [[phenotype]] results from the interaction of two loci, one on the homologous part of the X and Y and one on the nonhomologous sequence of the Y.<ref>{{cite journal | pmid = 14110028 | doi=10.1038/201424b0 | volume=201 | year=1964 | journal=Nature | pages=424–5 | last1 = Dronamraju | first1 = KR| title=Y-linkage in Man | issue=4917 | bibcode=1964Natur.201..424D | s2cid=4275336 }}</ref> These hypotheses are not mutually exclusive, and there may be a variety of genetic mechanisms underlying this phenotype.
Lee et al. (2004), using Y-chromosomal DNA binary-marker haplotyping, suggested that a cohort of southern Indian hairy-eared males carried Y chromosomes from many [[haplogroups|haplogroup]].<ref>{{cite journal | pmid = 15367914 | doi=10.1038/sj.ejhg.5201271 | volume=12 | title=Molecular evidence for absence of Y-linkage of the Hairy Ears trait | year=2004 | journal=Eur J Hum Genet | pages=1077–9 | last1 = Lee | first1 = AC | last2 = Kamalam | first2 = A | last3 = Adams | first3 = SM | last4 = Jobling | first4 = MA| issue=12 | doi-access = free }}</ref> The hypothesis of Y- linkage would require multiple independent mutations within a single [[population]]. No significant difference between the Y-haplogroup frequencies of hairy-eared males and those of a geographically matched control sample of unaffected males was established. The study concluded that auricular hypertrichosis is not Y-linked in southern India, though this result may not apply to all to all populations.<ref>{{cite journal | pmid = 4669458 | doi=10.1017/s1120962300010933 | volume=21 | title=Hypertrichosis of the ear rims. Two remarks on the two-gene hypothesis | year=1972 | journal=Acta Genet Med Gemellol (Roma) | pages=216–20 | last1 = Rao | first1 = DC| issue=3 | doi-access=free }}</ref>
== See also ==
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