X-linked dominant inheritance: Difference between revisions

Revision as of 13:15, 29 September 2021

Revision as of 10:07, 1 February 2022

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In such a case, where both parents carry and thus are affected by an X-linked dominant disorder, the chance of a daughter receiving two copies of the X chromosome with the defective gene is 50%, since daughters receive one copy of the X chromosome from both parents. Were this to occur with an X-linked dominant disorder, that daughter would likely experience a more severe form.

Some X-linked dominant conditions such as [[Aicardi syndrome]] are fatal to boys,; therefore only girls with these conditions survive, or boys with [[Klinefelter's syndrome]] (and hence have more than one X chromosome).

A few scholars have suggested discontinuing the use of the terms ''dominant'' and ''recessive'' when referring to X-linked inheritance, stating that the highly variable penetrance of X-linked traits in females as a result of mechanisms such as [[skewed X-inactivation]] or [[somatic mosaicism]] is difficult to reconcile with standard definitions of dominance and recessiveness.<ref name="pmid15316978">{{cite journal|vauthors=Dobyns WB, Filauro A, Tomson BN, Chan AS, Ho AW, Ting NT, Oosterwijk JC, Ober C|date=August 2004|title=Inheritance of most X-linked traits is not dominant or recessive, just X-linked|journal=American Journal of Medical Genetics. Part A|volume=129A|issue=2|pages=136–43|doi=10.1002/ajmg.a.30123|pmid=15316978}}</ref>