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Dstl was formed from the July 2001 split of the [[Defence Evaluation and Research Agency]] (DERA). Dstl was established to carry out and retain the science and technology work that is best done within government,<ref>{{cite web |url=https://www.dstl.gov.uk/downloads/framework.pdf |title=Archived copy |access-date=16 February 2014 |archive-url=https://web.archive.org/web/20140222100131/https://www.dstl.gov.uk/downloads/framework.pdf |archive-date=22 February 2014 |url-status=dead}}</ref> while work that could be done by industry (forming the majority of DERA's activities) was transferred to [[Qinetiq]], a government-owned company that was later floated on the stock exchange.
Dstl absorbed the Home Office's Centre for Applied Science and Technology (CAST) in April 2018,<ref name=":1">{{
Dstl was a [[trading fund]] of the MOD from its formation until 2016, when it became an [[executive agency]] of the MOD.
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* [[Porton Down]], Wiltshire (headquarters)
* [[Portsdown Hill|Portsdown West]], Hampshire
The former CAST sites at [[Langhurst|Langhurst, West Sussex]] and [[Sandridge]], Hertfordshire were closed around 2020 after the 2018 merger of CAST into Dstl.<ref name=":1" />
Sections of 150-millimetre-thick (5.9 in) [[Low-background steel|pre-atomic steel]] plate uncontaminated with [[radionuclide]]s, recovered from [[HMS Vanguard (23)|HMS ''Vanguard'']], were used for the shielding of the [[Whole Body Counter|whole body monitor]] at the Radiobiological Research Laboratory (now Dstl) at [[Alverstoke]], [[Gosport]], Hampshire.<ref>{{cite journal|last=Cowling|first=Giles|title=From Land, Sea and Air|url=http://www.defencemanagement.com/article.asp?id=200&content_name=National%20Security%20and%20Resilience&article=5132|url-status=dead|journal=Defence Management Journal|volume=31|archive-url=https://web.archive.org/web/20120225191422/http://www.defencemanagement.com/article.asp?id=200&content_name=National%20Security%20and%20Resilience&article=5132|archive-date=25 February 2012}}</ref>
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