The journal publishes both original research and review articles. All articles are [[open access]] and licensed under the [[Creative Commons Attribution License]].<ref>{{Cite web |url=http://journals.plos.org/ploscompbiol/s/journal-information |title=PLOS Computational Biology: A Peer-Reviewed Open-Access Journal |website=journals.plos.org |access-date=2017-03-24}}</ref> StartingSince init 2005inception, the the journal beganhas publishing articles forpublished the now famous "Ten Simple Rules" series of practical guides,<ref>{{Cite journal |last=Bourne |first=Philip E |date=2006-08-25 |title=One Year of PLoS Computational Biology |url=https://dx.plos.org/10.1371/journal.pcbi.0020111 |journal=PLoS Computational Biology |language=en |volume=2 |issue=8 |pages=e111 |doi=10.1371/journal.pcbi.0020111 |issn=1553-7358 |pmc=PMC1553486 |pmid=17523253}}</ref><ref>{{cite web | url=https://collections.plos.org/collection/ten-simple-rules/ | title=Ten Simple Rules }}</ref> which has subsequently become one of the journals most read article series.<ref>{{Cite journal |last=Bourne |first=Philip E. |last2=Lewitter |first2=Fran |last3=Markel |first3=Scott |last4=Papin |first4=Jason A. |date=2018-12-20 |title=One thousand simple rules |url=https://dx.plos.org/10.1371/journal.pcbi.1006670 |journal=PLOS Computational Biology |language=en |volume=14 |issue=12 |pages=e1006670 |doi=10.1371/journal.pcbi.1006670 |issn=1553-7358 |pmc=PMC6301566 |pmid=30571692}}</ref> In 2012, it launched the "Topic Page" review format, which dual-publishes peer-reviewed articles both in the journal and on Wikipedia.<ref>{{Cite journal |last1=Wodak |first1=Shoshana J. |last2=Mietchen |first2=Daniel |last3=Collings |first3=Andrew M. |last4=Russell |first4=Robert B. |last5=Bourne |first5=Philip E. |date=2012-03-29 |title=Topic Pages: PLOS Computational Biology Meets Wikipedia |journal=PLOS Computational Biology |volume=8 |issue=3 |pages=e1002446 |doi=10.1371/journal.pcbi.1002446 |pmc=3315447 |pmid=22479174|bibcode=2012PLSCB...8E2446W }}</ref><ref>{{Cite web |url=http://collections.plos.org/topic-pages |title=PLOS Collections: Topic Pages |website=PLOS Computational Biology |access-date=2017-03-24}}</ref> It was the first publication of its kind to publish in this way.<ref>{{Cite web |url=https://blog.wikimedia.org/2016/10/29/wikipedia-medical-content/ |title=Wikipedia's medical content: A new era of collaboration |website=blog.wikimedia.org |date=29 October 2016 |publisher=[[Wikimedia Foundation]] |access-date=2017-03-24}}</ref><ref>{{Cite journal |last=Shafee |first=Thomas |date=2017 |title=Wikipedia-integrated publishing: a comparison of successful models |url=https://www.hlinc.org.au/content/open-access/item/wikipedia-integrated-publishing-a-comparison-of-successful-models?category_id=28 |journal=Health Inform |volume=26 |issue=2 |pages= |doi=10.13140/RG.2.2.27470.77129}}</ref>
