Cellular memory modules: Difference between revisions

Revision as of 15:09, 20 April 2023

Revision as of 15:10, 20 April 2023

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== Introduction[edit] ==

Cellular memory modules are a form of [[Transgenerational epigenetic inheritance|epigenetic inheritance]] that allow cells to maintain their original identity after a series of [[Cell division|cell divisions]] and developmental processes. Cellular memory modules implement these preserved characteristics into transferred environments through [[transcriptional memory]] <ref>{{Citation |last=Paro |first=Renato |title=Cellular Memory |date=2021 |url=https://doi.org/10.1007/978-3-030-68670-3_3 |work=Introduction to Epigenetics |pages=49–66 |editor-last=Paro |editor-first=Renato |access-date=2023-04-20 |place=Cham |publisher=Springer International Publishing |language=en |doi=10.1007/978-3-030-68670-3_3 |isbn=978-3-030-68670-3 |last2=Grossniklaus |first2=Ueli |last3=Santoro |first3=Raffaella |last4=Wutz |first4=Anton |editor2-last=Grossniklaus |editor2-first=Ueli |editor3-last=Santoro |editor3-first=Raffaella |editor4-last=Wutz |editor4-first=Anton}}</ref>. Cellular memory modules are primarily found in ''[[Drosophila]]''.

== History ==

Cellular memory modules were discovered by [[François Jacob]] and [[Jacques Monod|Jaques Monod]] in 1961 at the [[Pasteur Institute]] in Paris. The discovery led to Jacob and Monod, along with [[André Michel Lwoff|André Lwoff]], receiving The Nobel Prize in Physiology or Medicine in 1965 for their discoveries regarding genetic control of enzyme and virus synthesis. These experimental results mapped the complex processes in which self-regulating processes express or suppress genes. Monod and Jacob proved how genetic information conversion during the [[Protein biosynthesis|construction of proteins]] was done through a messenger which evinced [[RNA]] <ref>{{Cite web |title=The Nobel Prize in Physiology or Medicine 1965 |url=https://www.nobelprize.org/prizes/medicine/1965/monod/facts/ |access-date=2023-04-18 |website=NobelPrize.org |language=en-US}}</ref>. Lwoff aided in the experiment that won the Nobel Prize but did not work on the series of experiments that led to the discovery of cellular memory modules, which is why he remains uncredited in its discovery.

==References==