Complement component 2: Difference between revisions

Revision as of 01:04, 3 May 2023

Revision as of 01:06, 3 May 2023

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Photosensitive patients with C2 type I deficiency have poor prognosis. C2 type I deficiency is caused by a 28-base pair gene deletion, resulting in premature termination codon and lack of C2 protein. Patients with LE associated with complement C4 or C2 deficiencies have a better prognosis than those without inherited deficiencies. Complement component 2 deficiency increases risk of autoimmune disorders which may be managed by receiving the adequate care. Clinically, this is significant since Complement component 2 deficiency increases the risk of recurrent bacterial infections, which may be life-threatening.

== Other Names ==

There are numerous forms of naming this gene. For example:

* ARMD14

For example:

* C3/C5 convertase

ARMD14

* CO2

C3/C5 convertase

* complement component C22

CO2

* complement component 2C2

complement component C2

== References ==

=== CitationCitations ===

{{reflist}}

=== Bibliography ===

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* Outer surface lipoproteins from the Lyme disease spirochete exploit the molecular switch mechanism of the complement protease C1s. arrigues et al.Journal of Biological ChemistrySeptember 29, 2022

* Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail

* Sagae et al.Journal of Biological ChemistryMarch 17, 2022

{{refend}}