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Lindeberg<ref>[http://kth.diva-portal.org/smash/record.jsf?pid=diva2%3A472969&dswid=2693 Lindeberg, T.: Detecting salient blob-like image structures and their scales with a scale-space primal sketch: A method for focus-of-attention, International Journal of Computer Vision, 11(3), 283–318, 1993.]</ref><ref name=lin94>[http://www.csc.kth.se/~tony/book.html Lindeberg, Tony, Scale-Space Theory in Computer Vision, Kluwer Academic Publishers, 1994], {{ISBN|0-7923-9418-6}}</ref> studied the problem of linking local extrema and saddle points over scales, and proposed an image representation called the scale-space primal sketch which makes explicit the relations between structures at different scales, and also makes explicit which image features are stable over large ranges of scale including locally appropriate scales for those. Bergholm proposed to detect edges at coarse scales in scale-space and then trace them back to finer scales with manual choice of both the coarse detection scale and the fine localization scale.
Gauch and Pizer<ref>[http://portal.acm.org/citation.cfm?coll=GUIDE&dl=GUIDE&id=628490 Gauch, J. and Pizer, S.: Multiresolution analysis of ridges and valleys in grey-scale images, IEEE Transactions on Pattern Analysis and Machine Intelligence, 15:6 (June 1993), pages: 635–646, 1993.]</ref> studied the complementary problem of ridges and valleys at multiple scales and developed a tool for interactive image segmentation based on multi-scale watersheds. The use of multi-scale watershed with application to the gradient map has also been investigated by Olsen and Nielsen<ref>Olsen, O. and Nielsen, M.: [https://link.springer.com/content/pdf/10.1007/3-540-63507-6_178.pdf Multi-scale gradient magnitude watershed segmentation], Proc. of ICIAP 97, Florence, Italy, Lecture Notes in Computer Science, pages 6–13. Springer Verlag, September 1997.</ref> and been carried over to clinical use by Dam.<ref>Dam, E., Johansen, P., Olsen, O. Thomsen,, A. Darvann, T., Dobrzenieck, A., Hermann, N., Kitai, N., Kreiborg, S., Larsen, P., Nielsen, M.: "Interactive multi-scale segmentation in clinical use" in European Congress of Radiology 2000.</ref> Vincken et al.<ref>
These ideas for multi-scale image segmentation by linking image structures over scales have also been picked up by Florack and Kuijper.<ref>Florack, L. and Kuijper, A.: The topological structure of scale-space images, Journal of Mathematical Imaging and Vision, 12:1, 65–79, 2000.</ref> Bijaoui and Rué<ref>{{cite journal | last1 = Bijaoui | first1 = A. | last2 = Rué | first2 = F. | year = 1995 | title = A Multiscale Vision Model | journal = Signal Processing | volume = 46 | issue = 3| page = 345 | doi=10.1016/0165-1684(95)00093-4}}</ref> associate structures detected in scale-space above a minimum noise threshold into an object tree which spans multiple scales and corresponds to a kind of feature in the original signal. Extracted features are accurately reconstructed using an iterative conjugate gradient matrix method.
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