Content deleted Content added
Ira Leviton (talk | contribs) Fixed a PMC parameter in a citation and section headings. Please see Category:CS1 maint: PMC format. |
reformatted refs and prep for citation bot cleanup |
||
Line 1:
{{Orphan|date=December 2023}}
'''Probiotic Probio DR10''', is the consumer brand name for a probiotic strain developed by Fonterra Research Development Centre (FRDC), patented and commercialised in the 1990s following the screening of over 2,000 strains.<ref>{{
The strain involved is a lactic acid bacterium of ''Bifidobacterium lactis'', originally isolated from yoghurt.<ref name=":0">{{
The Probio DR10<sup>TM~</sup> strain is available in a range of finished formats, providing it with great potential to be applied across the food and beverage, dietary supplement, and pharmaceutical industries.<ref name=":3" />''Bifidobacterium lactis'' is found in Anmum<sup>TM</sup> Materna and Anmum<sup>TM</sup> Essential Gold in the Malaysian market.
Line 12:
===Immune system support===
Probio DR10<sup>TM~</sup> demonstrated extensive immune-stimulating effects in animal models as well as healthy adult and elderly clinical studies. In a randomised controlled trial (RCT) conducted with children aged 1 to 3 years, it was found that the incidence of high fever and severe acute lower respiratory infections was reduced by 5% and 35% respectively, in children who received Probio DR10<sup>TM~</sup> along with a prebiotic, in comparison to those who were administered a placebo.<ref name="Sazawal e12164">{{
A separate RCT also showed that the supplementation of Probio DR10<sup>TM~</sup> in children aged 2 to 5 years reduced the incidence of diarrhoea and fever by 16.1% and 12.7% respectively during the rainy season.<ref>{{
===Modulation of intestinal microbiota===
Probio DR10<sup>TM~</sup> may increase the population of beneficial gut microflora of ''Bifidobacterium'' and ''Lactobacillus''.<ref>{{
Probio DR10<sup>TM~</sup> has also been shown to help maintain a healthy/normal gut microbiota against the ageing process by competing with and excluding harmful pathogens, operating at both taxonomical and functional levels.<ref name=":3" />
Line 30:
===Regulation of gut motility and improvement of gastrointestinal symptoms===
Probio DR10<sup>TM~</sup> has demonstrated a positive effect on individuals suffering from constipation.<ref name=":3" /> A New Zealand study involving 100 adults with functional gastrointestinal symptoms showed that the supplementation of Probio DR10<sup>TM~</sup> for 2 weeks alleviated constipation by reducing the gut transit time.<ref name=":1">{{
Reductions in the frequency of other functional gastrointestinal symptoms, including vomiting, regurgitation, abdominal pain, nausea, gurgling, irregular bowel movements, diarrhoea and flatulence were also observed in the same study.<ref name=":1" />
Line 42:
===Not all probiotics are the same===
Studies have shown that not all probiotics are equally effective.<ref name=":2">{{
== Mechanism of action ==
Line 49:
Studies indicate that this strain acts on intercellular junctions, especially tight junctions.<ref name=":0" /> Tight junctions are situated in the most apical part of the cell and consist of two key proteins, claudin and occludin.<ref name=":0" /> These proteins play a crucial role in establishing the epithelial barrier, which acts as a safeguard against the entry of macromolecules, including lipids and proteins.<ref name=":0" />
These junctions are vital for controlling the permeability of the epithelium.<ref name=":0" /> Any changes in their function can lead to increased inflammation, and subsequently, the development of diseases.<ref name=":0" /><ref>{{
== Safety ==
The presence of ''Bifidobacterium animalis'' subsp. ''lactis'' in human food has been documented since 1980, but it was likely part of human diets before that.<ref name=":3" />
The China National Center for Food Safety Risk Assessment (CFSA) has also approved the use of ''B. lactis'' in food for the general and paediatric population.<ref>{{Cite web |title=China National Center for Food Safety Risk Assessment
A 2018 study found that Probio DR10<sup>TM~</sup> is well-tolerated in adults and did not induce changes in physical activity, food intake, or body weight.<ref>{{
== References ==
| |||