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The [[p53]] tumor suppressor is arguably the most important agent in preventing tumor formation and progression. The p53 protein functions as a transcription factor with a crucial role in orchestrating the cellular stress response. In addition to its crucial role in cancer, p53 has been implicated in other diseases including diabetes, cell death after ischemia, and various neurodegenerative diseases such as Huntington, Parkinson, and Alzheimer. Studies have suggested that p53 expression is subject to regulation by non-coding RNA.<ref name="MorrisKV"/>
Another example of non-coding RNA dysregulated in cancer cells is the long non-coding RNA Linc00707. Linc00707 is upregulated and sponges miRNAs in human bone marrow-derived mesenchymal stem cells,<ref>{{cite journal | vauthors = Jia B, Wang Z, Sun X, Chen J, Zhao J, Qiu X | title = Long noncoding RNA LINC00707 sponges miR-370-3p to promote osteogenesis of human bone marrow-derived mesenchymal stem cells through upregulating WNT2B | journal = Stem Cell Research & Therapy | volume = 10 | issue = 1 | pages = 67 | date = February 2019 | pmid = 30795799 | pmc = 6387535 | doi = 10.1186/s13287-019-1161-9 | doi-access = free }}</ref> in hepatocellular carcinoma,<ref>{{cite journal | vauthors = Tu J, Zhao Z, Xu M, Chen M, Weng Q, Wang J, Ji J | title = LINC00707 contributes to hepatocellular carcinoma progression via sponging miR-206 to increase CDK14 | journal = Journal of Cellular Physiology | volume = 234 | issue = 7 | pages = 10615–10624 | date = July 2019 | pmid = 30488589 | doi = 10.1002/jcp.27737 | s2cid = 54119752 }}{{Retracted|doi=10.1002/jcp.30712|pmid=35297045}}</ref> gastric cancer<ref>{{cite journal | vauthors = Xie M, Ma T, Xue J, Ma H, Sun M, Zhang Z, Liu M, Liu Y, Ju S, Wang Z, De W | display-authors = 6 | title = The long intergenic non-protein coding RNA 707 promotes proliferation and metastasis of gastric cancer by interacting with mRNA stabilizing protein HuR | journal = Cancer Letters | volume = 443 | pages = 67–79 | date = February 2019 | pmid = 30502359 | doi = 10.1016/j.canlet.2018.11.032 | s2cid = 54611497 }}</ref> or breast cancer,<ref>{{cite journal | vauthors = Li T, Li Y, Sun H | title = MicroRNA-876 is sponged by long noncoding RNA LINC00707 and directly targets metadherin to inhibit breast cancer malignancy | journal = Cancer Management and Research | volume = 11 | pages = 5255–5269 | date = 2019-06-06 | pmid = 31239777 | pmc = 6559252 | doi = 10.2147/cmar.s210845 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Yuan RX, Bao D, Zhang Y | title = Linc00707 promotes cell proliferation, invasion, and migration via the miR-30c/CTHRC1 regulatory loop in breast cancer | journal = European Review for Medical and Pharmacological Sciences | volume = 24 | issue = 9 | pages = 4863–4872 | date = May 2020 | pmid = 32432749 | doi = 10.26355/eurrev_202005_21175 | s2cid = 218759508 }}</ref> and thus promotes osteogenesis, contributes to hepatocellular carcinoma progression, promotes proliferation and metastasis, or indirectly regulates expression of proteins involved in cancer aggressiveness, respectively.
===Prader–Willi syndrome===
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