Fast statistical alignment: Difference between revisions

Revision as of 19:43, 1 July 2024

Revision as of 21:30, 19 June 2025

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{{No inline|date=June 2024}}{{Infobox Software|name=FSA|developer=Robert Bradley ([[UC Berkeley]]), Colin Dewey ([[UW Madison]]), [[Lior Pachter]] ([[UC Berkeley]])|latest_release_version=1.5.2|operating_system=[[UNIX]], [[Linux]], [[Apple Macintosh|Mac]]|genre=Bioinformatics tool|licence=Open source}}

'''Fast statistical alignment''' or ('''FSA''') is a [[multiple sequence alignment]] program for aligning many proteins, [[RNA]]s, or long genomic [[Nucleic acid sequence|DNA sequences]]. Along with [[MUSCLE (alignment software)|MUSCLE]] and [[MAFFT]], FSA is one of the few sequence alignment programs which can align datasets of hundreds or thousands of sequences. FSA uses a different optimization criterion which allows it to more reliably identify non-homologous sequences than these other programs, although this increased accuracy comes at the cost of decreased speed.

FSA is currently being used for multiple projects, including sequencing new worm genomes and analyzing ''in vivo'' transcription factor binding in flies.